Zobrazeno 1 - 10
of 14
pro vyhledávání: '"T. Matt Holl"'
Autor:
Laurent Verkoczy, M Anthony Moody, T Matt Holl, Hilary Bouton-Verville, Richard M Scearce, Jennifer Hutchinson, S Munir Alam, Garnett Kelsoe, Barton F Haynes
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7215 (2009)
The membrane proximal external region (MPER) of HIV-1 gp41 has several features that make it an attractive antibody-based vaccine target, but eliciting an effective gp41 MPER-specific protective antibody response remains elusive. One fundamental issu
Externí odkaz:
https://doaj.org/article/4ddc311bb46247718b7c614d0a4a0f22
Autor:
Robert Parks, M. Anthony Moody, Steven G. Reed, Roger E. McLendon, Nathan Vandergrift, Cindy M. Bowman, Ruijun Zhang, S. Munir Alam, Todd Bradley, Christopher B. Fox, Sampa Santra, T. Matt Holl, Laura L. Sutherland, Christopher B. Newgard, Hilary Bouton-Verville, Olga Ilkayeva, Jinsong Zhang, Laurent Verkoczy, Richard M. Scearce, Hua-Xin Liao, Barton F. Haynes, Guang Yang, Thomas B. Kepler, Garnett Kelsoe, Jeffrey I. Everitt
Publikováno v:
The Journal of Immunology. 197:4663-4673
The HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering viral control by the host. The tryptophan metabolic enzyme kynureninase (KYNU) is mimicked by a portion of the HIV Env gp41 membrane proximal region (MPER) and
Autor:
M. Anthony Moody, T. Matt Holl, Laurent Verkoczy, Barton F. Haynes, Garnett Kelsoe, S. Munir Alam, Masayuki Kuraoka, Guang Yang
Publikováno v:
The Journal of Immunology. 192:3269-3279
We have shown that the protective HIV-1 Ab, 2F5, avidly reacts with a conserved mammalian self-Ag, kynureninase, and that the development of B cells specific for the 2F5 epitope is constrained by immunological tolerance. These observations suggest th
Autor:
Ying-Bin Ouyang, Marilyn Diaz, Barton F. Haynes, S. Munir Alam, Yao Chen, Kwan-Ki Hwang, T. Matt Holl, Garnett Kelsoe, Jinsong Zhang, Jennifer Hutchinson, Hilary Bouton-Verville, Laurent Verkoczy
Publikováno v:
The Journal of Immunology. 187:3785-3797
The HIV-1 broadly neutralizing Ab (bnAb) 2F5 has been shown to be poly-/self-reactive in vitro, and we previously demonstrated that targeted expression of its VDJ rearrangement alone was sufficient to trigger a profound B cell developmental blockade
Autor:
Alexander E. Reynolds, Dongmei Liao, Mandy Womble, T. Matt Holl, Masayuki Kuraoka, Garnett Kelsoe, Derek W. Cain
Publikováno v:
Proceedings of the National Academy of Sciences. 108:11560-11565
The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision
Autor:
Eda K. Holl, T. Matt Holl, Albert G. Zimmermann, Brian P. O'Connor, Kelly E. Roney, Garnett Kelsoe, Sushmita Jha, Jenny P.-Y. Ting
Publikováno v:
The Journal of Immunology. 186:5603-5611
Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis
Publikováno v:
International Journal of Experimental Pathology. 91:472-483
Oil granuloma (OG) induced by intraperitoneal injection of pristane represents a non-infectious granuloma. Oil granuloma has been characterized, but the regulation of its formation still remains unknown. To address this, we injected pristane into var
Stromal cell independent B cell development in vitro: Generation and recovery of autoreactive clones
Publikováno v:
Journal of Immunological Methods. 354:53-67
We describe and characterize a stromal cell independent culture system that efficiently supports pro-B cell to IgM+ B cell development with near normal levels of IgH and Igkappa diversity. Pro-B cells present in non-adherent bone marrow cells prolife
Autor:
M. Anthony Moody, T. Matt Holl, Garnett Kelsoe, Robert Parks, Barton F. Haynes, Mattia Bonsignori, Georgia D. Tomaras, Nathan Vandergrift, Charles B. Hicks
Publikováno v:
The Journal of Immunology. 183:2708-2717
Successful vaccines (i.e., tetanus and diphtheria) can induce long-lived Ab levels that are maintained by bone marrow plasma cells and plasma Ab levels do not correlate with numbers of blood memory B cells. Destruction of CD4+ T cells early in HIV-1
Autor:
Huaiyong, Chen, Dongmei, Liao, T Matt, Holl, Pilar, Snowden, Yoshihiro, Ueda, Garnett, Kelsoe
Publikováno v:
International journal of experimental pathology. 91(5)
Oil granuloma (OG) induced by intraperitoneal injection of pristane represents a non-infectious granuloma. Oil granuloma has been characterized, but the regulation of its formation still remains unknown. To address this, we injected pristane into var