MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Autor: Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto-Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, David R. Raleigh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Meningiomas are associated with inactivation of NF2/Merlin, but approximately one-third of meningiomas with favorable clinical outcomes retain Merlin expression. Biochemical mechanisms underlying Merlin-intact meningioma growth are incomplet

Externí odkaz: https://doaj.org/article/09cad89a882942b286e00cb8af45c58a

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance

Autor: Harish N. Vasudevan, Emily Payne, Cyrille L. Delley, S. John Liu, Kanish Mirchia, Matthew J. Sale, Sydney Lastella, Maria Sacconi Nunez, Calixto-Hope G. Lucas, Charlotte D. Eaton, Tim Casey-Clyde, Stephen T. Magill, William C. Chen, Steve E. Braunstein, Arie Perry, Line Jacques, Alyssa T. Reddy, Melike Pekmezci, Adam R. Abate, Frank McCormick, David R. Raleigh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Schwann cell tumors are the most common cancers of the peripheral nervous system and can arise in patients with neurofibromatosis type-1 (NF-1) or neurofibromatosis type-2 (NF-2). Functional interactions between NF1 and NF2 and broader mecha

Externí odkaz: https://doaj.org/article/a34dc09304394fd3ae1c29c108fd0bbd

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma

Autor: Stephen T. Magill, Harish N. Vasudevan, Kyounghee Seo, Javier E. Villanueva-Meyer, Abrar Choudhury, S. John Liu, Melike Pekmezci, Sarah Findakly, Stephanie Hilz, Sydney Lastella, Benjamin Demaree, Steve E. Braunstein, Nancy Ann Oberheim Bush, Manish K. Aghi, Philip V. Theodosopoulos, Penny K. Sneed, Adam R. Abate, Mitchel S. Berger, Michael W. McDermott, Daniel A. Lim, Erik M. Ullian, Joseph F. Costello, David R. Raleigh

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperativel

Externí odkaz: https://doaj.org/article/009c5504e81841cb823079d832c9273c

External validation and recalibration of an incidental meningioma prognostic model – IMPACT: protocol for an international multicentre retrospective cohort study

Autor: Julie Woodfield, Boris Krischek, Giles Critchley, Damian Holliman, Angelos Kolias, Thomas Santarius, Ola Rominiyi, Michael McDermott, Michael D Jenkinson, Jörg-Christian Tonn, Mohsen Javadpour, Andrea Saladino, Tiit Illimar Mathiesen, Rory Piper, Michael Vogelbaum, Chaya Brodie, Sara Venturini, Daniel M Fountain, Roland Goldbrunner, Elliot Tilling, Felix Sahm, Priscilla Brastianos, Rory J Piper, Antonio Santoro, Sylvia Kurz, Pierfrancesco Lapolla, Andrea Mingoli, Jennifer Brown, Debraj Mukherjee, Simon Walling, Andrew Morokoff, Patrick Wen, Ghazaleh Tabatabai, Jill Barnholtz-Sloan, Ryan K Mathew, Alexander Smedley, Helen Shih, William Taylor, Minh Nguyen, Bryony Ford, Samantha J Mills, Tamara Ali, Ruwanthi Kolamunnage-Dona, Josephine Jung, Muhammed Elhadi, Erminia Albanese, Aswin Chari, David Rowland, Melissa Gough, Michael Cearns, Simon Lammy, Yasir Chowdhury, Christian Mawrin, Mahmoud Saleh, Jens Schittenhelm, Farshad Nassiri, Raymond Huang, Pietro Familiari, Manfred Westphal, Warren Selman, Daniel Brown, Nathan McSorley, Oliver Hanemann, Richard Pullicino, Francesco Gaillard, Mirjam Renovanz, Chris Barrett, Christine Jungk, Aaron Cohen-Gadol, Javier Martín-Alonso, Gelareh Zadeh, Hytham Hamid, Abdurrahman I Islim, Christopher P Millward, Shaveta Mehta, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Andrew R Brodbelt, Mohamed Abdelsadg, Suhaib Abualsaud, Amro Abuleil, Kevin Agyemang, Hanan Akbari, Likhith Alakandy, Clarissa Alfonso, Arousa Ali, Michael Amoo, Mohamed A. R. Arbab, Mutiu Asha, Kareem Austin, Khaled Badran, Jarnail Bal, Parameswaran Bhattathiri, Paul M. Brennan, Andrew R. Brodbelt, Ferran Brugada-Bellsolà, Placido Bruzzaniti, Annabel Butcher, Rory S. Cairns, Michael Canty, Sachiv Chakravarti, Rebecca Chave-Cox, Anna Craig-McQuade, Peter Crossley, Elizabeth Culpin, Alessia D'Amico, Bassam Dabbous, Pedro David Delgado-López, Mohamed Draz, Katharine J. Drummond, Rusiru T. Ekanayaka, Ibrahim Elmaadawi, Omar Elmandouh, Mazin Elsharif, Daisy Evans, Andreas Fahlström, Fleur L. Fisher, Daniel M. Fountain, Keiko Fox, Chloé Gelder, Shamayitri Ghosh, Aimee Goel, Athanasios Grivas, Andrew Gvozdanovic, Allan Hall, Liv Hartrick, Samih Hassan, Jack Henry, Abdurrahman I. Islim, Asgeir S. Jakola, Michael D. Jenkinson, Sanjeeva Jeyaretna, Adrian Jimenez, Andranik Kahramanian, Neeraj Kalra, David O. Kamson, Oliver Kennion, Adham M. Khalafallah, Sarah Kingdon, Howra Ktayen, Aditaya Kumar, Jun Yi Lau, Jing Xian Lee, Ryan Leyden, Patricia Littlechild, Sophie Liu, Darmanin Lora-Kay, Vivia Lung, Stephen T. Magill, Hani J. Marcus, Fawaz E. Marhoom, Ryan K. Mathew, Calan Mathieson, Tobias Mederer, Torstien R. Meling, Samantha J. Mills, Christopher P. Millward, Mujtaba Mohammad, Amir H. Zamanipoor Najafabadi, Olivia Näslund, Imran Noorani, Gildas Patet, Omar N. Pathmanaban, Andrea Perera, Amit Persad, See Yung Phang, Rory J. Piper, Jonathan Pollock, Benjamin Price, Martin Proescholdt, James Robins, Bobby Sachdev, Fozia Saeed, Ieva Sataite, Antony Kevin Scafa, Verena Schadewaldt, Syed Wajahat Shah, Mustafa El Sheikh, Zenab Sher, Bente Sandvei Skeie, Agbolahan Sofela, Jerome St George, Torbjørn Strømsnes, Nigel Suttner, Philip Theodosopoulos, Manjul Tripathi, Ismail Ughratdar, James Ulrich, Adithya Varma, Anil Varma, Maria Velicu, Esther Wu, Jacob Young, Giuseppa Zancana, Catherine Zhang, Karolyn Au, Felix Behling, Linda Bi, Nicholas Butowski, Ana Castro, Marta Couce, Francesco Dimeco, Katherine J. Drummond, Ian Dunn, Craig Erker, Michelle Felicella, Eva Galanis, Norbert Galldiks, Caterina Giannini, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Gerhard Jungwirth, Timothy Kaufmann, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Jennifer Moliterno-Gunel, HK Ng, Houtan Noushmehr, Arie Perry, Laila Poisson, Bianco Pollo, Aditya Ragunathan, David Raleigh, Franz Ricklefs, Antonio Santacroce, Christian Schichor, Nils Schimdt, Andrew Sloan, Matija Snuderl, Jim Snyder, Erik Sulman, Suganth Suppiah, Marcos Tatagiba, Marco Timmer, Andreas Von Deimling, Tobias Walbert, Justin Z. Wang, Stephen Yip, Gabriel Zada, Viktor Zherebitskiy, Michael T.C. Poon

Publikováno v: BMJ Open, Vol 12, Iss 1 (2022)

Externí odkaz: https://doaj.org/article/0926b56220df490c910070692f8601b3

WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index

Autor: Alexander F. Haddad, Jacob S. Young, Ishan Kanungo, Sweta Sudhir, Jia-Shu Chen, David R. Raleigh, Stephen T. Magill, Michael W. McDermott, Manish K. Aghi

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Objective: In this study, we identify clinical, radiographic, and histopathologic prognosticators of overall, early, and post-median recurrence in World Health Organization (WHO) grade I meningiomas. We also determine a clinically relevant cutoff for

Externí odkaz: https://doaj.org/article/1e3e4afed3354ce5930f4f767b3dfa36