Výsledky vyhledávání - "T. M. Pawlik"

Is a diverting loop ileostomy and colonic lavage an alternative to colectomy for the treatment of severe Clostridium difficile–associated disease?

Publikováno v: Canadian Journal of Surgery. 57:214-216

The term “evidence-based medicine” was first coined by Sackett and colleagues as “the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients.”1 The key to practising eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61081a0e49f141d5202ed2cd86022913
https://doi.org/10.1503/cjs.005014

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What is the effect of screening mammography on breast cancer incidence?

Publikováno v: Canadian Journal of Surgery. 57:67-69

Objective: To determine if screening mammography produced the expected increase in the incidence of early-stage breast cancer and reduced the expected incidence of late-stage breast cancer in women 40 years of age or older. Design: Population-based o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e192b10e2205e452c930fee9cf27670
https://doi.org/10.1503/cjs.032913

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Synchronous Colorectal Liver Metastasis: A Network Meta-Analysis Review Comparing Classical, Combined, and Liver-First Surgical Strategies

Autor: M E, Kelly, G, Spolverato, G N, Lê, M N, Mavros, F, Doyle, T M, Pawlik, D C, Winter

In recent years, the management of synchronous colorectal liver metastasis has changed significantly. Alternative surgical strategies to the classical colorectal-first approach have been proposed. These include the liver-first and combined resections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::06bc31a0f288b75f406e56882677e2f9
http://hdl.handle.net/11577/3312048

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Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio in Patients After Resection for Hepato-Pancreatico-Biliary Malignancies

Autor: G, Spolverato, H, Maqsood, Y, Kim, Ga, Margonis, T, Luo, A, Ejaz, T M, Pawlik

We sought to determine whether Neutrophil-lymphocyte ratio (NLR) or platelet-lymphocyte ratio (PLR) were associated with outcomes of patients undergoing surgery for a hepatopancreatico-biliary (HPB) malignancy.Between 2000 and 2013, 452 patients who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6874dca6140e2554298fc44077489a21
http://hdl.handle.net/11577/3311930

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Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma

Autor: C Tang, Y Hou, H Wang, K Wang, H Xiang, X Wan, Y Xia, J Li, W Wei, S Xu, Z Lei, T M Pawlik, M Wu, F Shen

Publikováno v: Oncogenesis

The mechanism of aberrant mitochondrial genome and function in hepatocellular carcinoma (HCC) remains largely unknown. Our previous study demonstrated an increased expression of aspartate β-hydroxylase (ASPH) in HCC tissues, which was associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca0bc4dfa4a60e94c0ea2f9a011bdae
https://doi.org/10.1038/oncsis.2017.64

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Laparoscopic pancreatic surgery

Autor: J, He, T M, Pawlik, M A, Makary, C L, Wolfgang, M J, Weiss

Publikováno v: Minerva chirurgica. 69(6)

Laparoscopic pancreatectomy may be associated with lower operative morbidity, less postoperative pain, lower wound infection rates, decreased physiological stress, and fewer postoperative hernias and bowel obstructions. In this review, we summarize t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a548a19e59d9ab76e7d4cc55e455e5
https://pubmed.ncbi.nlm.nih.gov/25077736

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Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil

Autor: H, Nakamura, J T, Mullen, S, Chandrasekhar, T M, Pawlik, S S, Yoon, K K, Tanabe

Publikováno v: Cancer research. 61(14)

Infection of tumor cells by herpes simplex virus 1 (HSV-1) results in cell destruction and production of progeny virion in a process referred to as viral oncolysis. In this study, an HSV-1 mutant (HSV1yCD) was engineered such that the viral ribonucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb206526747f31e866580404bcd90d81
https://pubmed.ncbi.nlm.nih.gov/11454690

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Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus

Autor: T M, Pawlik, H, Nakamura, S S, Yoon, J T, Mullen, S, Chandrasekhar, E A, Chiocca, K K, Tanabe

Publikováno v: Cancer research. 60(11)

Herpes simplex virus type 1 (HSV-1) replication within tumors can mediate tumor regression (oncolysis). The genetically engineered, HSV-1 mutant rRp450 does not express viral ribonucleotide reductase and is therefore replication conditional. During t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed373c8dce8e4a9776636bb3b0a98037
https://pubmed.ncbi.nlm.nih.gov/10850415

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