Výsledky vyhledávání - "T. M. Newman"

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Autor: Vadivel Ganapathy, Srinivas Sonne, Scott A. Barman, Puttur D. Prasad, Shu Zhu, Sylvia B. Smith, Vinod K. Bhalla, Stefan Offermanns, Richard E. White, T. M. Newman

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832:1149-1158

Elevated levels of homocysteine produce detrimental effects in humans but its role in preterm birth is not known. Here we used a mouse model of hyperhomocysteinemia to examine the relevance of homocysteine to preterm birth. The mouse carries a hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ff45150a5f44e0884515ee76d5fa2d
https://doi.org/10.1016/j.bbadis.2013.04.006

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Effect of neuromimetics upon the release of atrial natriuretic peptide granules: Are multiple pathways involved in secretion?

Autor: N.J. Severs, T. M. Newman

Publikováno v: Journal of Cellular Physiology. 168:134-140

The release of atrial natriuretic peptide (ANP) in response to the application of neurohumoral agonists (neuromimetics) is directly demonstrated and quantified at the cellular level, using an ultrastructural assay developed to quantify secretion. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d4a58d7c9c9fe42204540ebcca0f2ec
https://doi.org/10.1002/(sici)1097-4652(199607)168:1<134::aid-jcp16>3.0.co

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A survey of GTP-binding proteins and other potential key regulators of exocytotic secretion in eosinophils. Apparent absence of rab3 and vesicle fusion protein homologues

Autor: Izumi Hide, Roberto Solari, T M Newman, Min Tian, Paige Lacy, Nicki Thompson, Bastien D. Gomperts

Publikováno v: Journal of Cell Science. 108:3547-3556

We set out to identify potential key regulators of exocytotic fusion in the eosinophil, in the knowledge that granule exocytosis can be stimulated in these cells by intracellular application of nonhydrolyzable analogues of guanosine triphosphate, wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd44e6abb4ec0ce8e91160112c208d8
https://doi.org/10.1242/jcs.108.11.3547

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Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils

Autor: A B Kay, NJ Severs, Janet North, Redwan Moqbel, Bastien D. Gomperts, Paige Lacy, T M Newman, Francesca Levi-Schaffer

Publikováno v: Blood. 85:2579-2586

We have previously shown that normal-density human peripheral blood eosinophils transcribe and translate mRNA for granulocyte-macrophage colony-stimulating factor (GM-CSF) and that the intracellular distribution was granular as assessed by light micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ff4207299143cf5b00af2271e548ae
https://doi.org/10.1182/blood.v85.9.2579.bloodjournal8592579

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SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes

Autor: A M, Badger, M N, Cook, M W, Lark, T M, Newman-Tarr, B A, Swift, A H, Nelson, F C, Barone, S, Kumar

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(1)

Nitric oxide (NO) is implicated in a number of inflammatory processes and is an important mediator in animal models of rheumatoid arthritis and in in vitro models of cartilage degradation. The pyridinyl imidazole SB 203580 inhibits p38 mitogen-activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e761c454fd860fd5a7229287319e67dd
https://pubmed.ncbi.nlm.nih.gov/9647257

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The Microanatomy of Airway Mucus Secretion

Autor: T M Newman, Duncan F. Rogers

Publikováno v: Airway Mucus: Basic Mechanisms and Clinical Perspectives ISBN: 9783034898096

Despite the importance of mucus secretion in airway physiology and pathophysiology, our understanding of the functional microanatomy of mucus release in mammalian airways is rudimentary. It is not clear how many different types of secretory granule m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee83b781d1cac0d1b0f9e5ef2b0b54bb
https://doi.org/10.1007/978-3-0348-8874-5_4

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Effect of neuromimetics upon the release of atrial natriuretic peptide granules: are multiple pathways involved in secretion?

Autor: T M, Newman, N J, Severs

Publikováno v: Journal of cellular physiology. 168(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1da925dbe583b499192956d1e579aee
https://pubmed.ncbi.nlm.nih.gov/8647907

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Identification of interleukin-2 in human peripheral blood eosinophils

Autor: F, Levi-Schaffer, J, Barkans, T M, Newman, S, Ying, M, Wakelin, R, Hohenstein, V, Barak, P, Lacy, A B, Kay, R, Moqbel

Publikováno v: Immunology. 87(1)

Interleukin-2 (IL-2) is an essential growth factor for T cells. Previous studies have shown that human peripheral eosinophils respond to IL-2 in chemotaxis and express the IL-2 receptor (CD25). In addition, eosinophils have been shown to transcribe m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99ff8aa162737d58c3770c2ff037e377
https://pubmed.ncbi.nlm.nih.gov/8666429

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Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product

Autor: R, Moqbel, S, Ying, J, Barkans, T M, Newman, P, Kimmitt, M, Wakelin, L, Taborda-Barata, Q, Meng, C J, Corrigan, S R, Durham, A B, Kay

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(10)

Human eosinophils are cytokine-producing cells that are prominent in IgE-dependent allergic tissue reactions. IL-4 promotes the development of the Th2-type phenotype in T cells and is an essential cofactor for IgE production by B cells. We detected m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bab3d3c48b993b19418bc0c7bc44299c
https://pubmed.ncbi.nlm.nih.gov/7594499

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The structure of the contractile apparatus in ultrarapidly frozen smooth muscle: freeze-fracture, deep-etch, and freeze-substitution studies

Autor: Steven B. Marston, T M Newman, J L Hodgkinson, Nicholas J. Severs

Publikováno v: Journal of structural biology. 114(2)

The structure of the smooth muscle contractile apparatus was studied using ultrarapid freezing followed by freeze substitution or by longitudinal freeze-fracture, deep-etch, and platinum-carbon replication. Freeze substitution minimises the detriment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188a11281538c0b2f7daf84f9e61de24
https://pubmed.ncbi.nlm.nih.gov/7612400

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