Zobrazeno 1 - 8 of 8 pro vyhledávání: '"T. M. Bargar"'
1
A Rapid and Efficient Method for Dehydration of Primary Amides to Nitriles. Preparation of Acrylonitrile Derivatives
Autor: T. M. Bargar, C. M. Riley
Publikováno v: Synthetic Communications. 10:479-487
Chloromethylene iminium salts (Vilsmeier reagents) have a long history and thoroughly investigated chemistry(1). Chloro-N, N-dimethylforminium chloride 1 is most conveniently generated by the reaction of N, N-dimethylformamide (DMF) with oxalyl chlor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3acb780a56c1172a797b79991d701333
https://doi.org/10.1080/00397918008064272
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2
3,4-Dihydro-2-phenyl-2H-pyrano[2,3-b]pyridines. Novel aza analogs of flavans
Autor: T. M. Bargar, Thomas Michael Wilson, J. K. Daniel
Publikováno v: Journal of Heterocyclic Chemistry. 22:1583-1592
Complementary approaches to the synthesis of the title compounds 1 are described. Metallation of 3,5-di-bromo-2-methoxypyridine (5b) by bromine/lithium exchange gave selectively the 3-lithio intermediate 6 which was trapped with substituted cinnamald
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8d058a4f626bff1b461e7772b116f0a
https://doi.org/10.1002/jhet.5570220624
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3
Synthesis of 9,10,11,12,12a,13-hexahydro-2,3-dimethoxy-7H-naphtho[l, 2-b]quinolizine hydrobromide. A cell growth inhibitor related to cryptopleurine
Autor: J. K. Dulworth, M. C. Graham, T. M. Bargar
Publikováno v: Journal of Heterocyclic Chemistry. 21:261-263
9,10,11,12,12a,13-Hexahydro-2,3-dimethoxy-7H-naphtho[1,2--6]quinolizine hydrobromide (4), which has structural similarity to cell growth inhibitory alkaloid cryptopleurine (1), was found to inhibit the growth of HeLa cells by 50% versus control at a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::176b5591f13185a3bee3491130c1ffd1
https://doi.org/10.1002/jhet.5570210153
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4
In vitro antiviral activity of the 6-substituted 2-(3',4'-dichlorophenoxy)-2H-pyrano[2,3-b]pyridines MDL 20,610, MDL 20,646, and MDL 20,957
Autor: J K Dulworth, M. C. Graham, A. M. Manelli, Michael T. Kenny, T M Bargar, H L Torney
Publikováno v: Antimicrobial Agents and Chemotherapy. 30:516-518
The 6-substituted 2-(3',4'-dichlorophenoxy)-2H-pyrano[2,3-b]pyridines MDL 20,610 (6-SO2CH3), MDL 20,646 (6-Br), and MDL 20,957 (6-Cl) are potent antirhinovirus compounds with median plaque 50% inhibitory concentrations (IC1/2s) of 0.03, 0.006, and 0.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044b4414bfb9a65585799bd4220f08a
https://doi.org/10.1128/aac.30.3.516
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6
3,4-Dihydro-2-phenyl-2H-pyrano[2,3-b]pyridines with potent antirhinovirus activity
Autor: Jacqueline K. Dulworth, Renee Massad, John K. Daniel, Michael T. Kenny, Roger N. Sargent, T. M. Bargar, Thomas Michael Wilson
Publikováno v: Journal of medicinal chemistry. 29(9)
A general synthesis to the title compounds 1, substituted in the 6-position and on the phenyl ring, is outlined. Eighteen analogues were compared with respect to in vitro activity against rhinovirus types 1A, 9, and 64. Compounds 1c and 1h, the 6-bro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25224187dbfd1cd5d1079f838fff33f0
https://pubmed.ncbi.nlm.nih.gov/3018241
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