Výsledky vyhledávání - "T. M. ARGENTIERI"

Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole-and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids

Autor: J A, Butera, S A, Antane, B, Hirth, J R, Lennox, J H, Sheldon, N W, Norton, D, Warga, T M, Argentieri

Publikováno v: Bioorganicmedicinal chemistry letters. 11(16)

Compounds in a structurally novel series of substituted 10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acids and related 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids were prepared and shown to possess potent, bladder-selective smooth muscle rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed0a6d01fbaf12e1cfc3515fd6c71eee
https://pubmed.ncbi.nlm.nih.gov/11514146

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Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat

Autor: M, Woods, N, Carson, N W, Norton, J H, Sheldon, T M, Argentieri

Publikováno v: The Journal of urology. 166(3)

Recent evidence indicates that in a number of species detrusor relaxation is mediated through activation of the beta3-adrenergic receptor. We determined whether activation of the beta3-adrenergic receptor would be a useful therapeutic approach for bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec62b90bc95b261cc2fe3fba246b33f5
https://pubmed.ncbi.nlm.nih.gov/11490313

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Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat

Autor: A, Wojdan, C, Freeden, M, Woods, G, Oshiro, W, Spinelli, T J, Colatsky, J H, Sheldon, N W, Norton, D, Warga, M M, Antane, S A, Antane, J A, Butera, T M, Argentieri

Publikováno v: The Journal of pharmacology and experimental therapeutics. 289(3)

The effects of the ATP-dependent potassium channel agonists ZD6169, celikalim, and WAY-133537 on bladder contractile function were examined in vitro on isolated bladder strips and in vivo on spontaneous bladder contractions. All three compounds produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::568e1e7c19ab32d0986781511c7fe2cd
https://pubmed.ncbi.nlm.nih.gov/10336534

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Inhibition of guinea pig detrusor contraction by NS-1619 is associated with activation of BKCa and inhibition of calcium currents

Autor: J H, Sheldon, N W, Norton, T M, Argentieri

Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(3)

The effects of NS-1619 on bladder contractile function and on transmembrane currents were evaluated in vitro on isolated guinea pig detrusor strips and isolated detrusor myocytes, respectively. In the isolated bladder strip, NS-1619 inhibited KCl-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9f756eb2a7a1946dda78fe39d0e2d10
https://pubmed.ncbi.nlm.nih.gov/9399993

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Acute administration of 17 beta-estradiol inhibits calcium currents in isolated guinea pig detrusor myocytes

Autor: J H, Sheldon, T M, Argentieri

Publikováno v: The Journal of pharmacology and experimental therapeutics. 274(2)

The acute effects of 17 beta-estradiol on bladder contractile function and on calcium currents were evaluated in vitro on isolated guinea pig bladder strips and detrusor myocytes, respectively. In the isolated bladder strip, 17 beta-estradiol inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8defc4a5a5cdd3a682e0f7a2de1dae74
https://pubmed.ncbi.nlm.nih.gov/7636734

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Metabolism and electrophysiology in subendocardial Purkinje fibers after infarction

Autor: L. H. Frame, K. G. Lurie, T. M. Argentieri, F. M. Matschinsky, J. Sheldon

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 253:H662-H670

Subendocardial Purkinje fibers (SEPF) have been implicated in the genesis of fatal arrhythmias that occur 24-48 h after infarction but little is known about the metabolic processes involved. Quantitative microchemical and electrophysiological studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4ecc9bb085361f27ac1eb78eeb6de5
https://doi.org/10.1152/ajpheart.1987.253.3.h662

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The etiology of toxic peripheral neuropathies: in vitro effects of acrylamide and 2,5-hexanedione on brain enolase and other glycolytic enzymes

Autor: R D, Howland, I L, Vyas, H E, Lowndes, T M, Argentieri

Publikováno v: Brain research. 202(1)

The in vitro effects of the neurotoxic compounds, acrylamide and 2,5-hexanedione, on several glycolytic enzymes including enolase, phosphofructokinase (PFK), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactic dehydrogenase (LDH) were studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6d5070ac2cb3379a37fa96ec79594d8
https://pubmed.ncbi.nlm.nih.gov/6448665

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