Zobrazeno 1 - 10
of 323
pro vyhledávání: '"T. Leanderson"'
Publikováno v:
The Journal of Immunology. 155:1132-1140
We have earlier shown that stimulation of human CD4+ T cells with SEA presented on Chinese hamster ovary (CHO)-DR transfectants coexpressing either B7 or LFA-3 resulted in distinct cytokine profiles. We now demonstrate that B7, but not LFA-3, strongl
Publikováno v:
Scandinavian journal of immunology. 54(4)
We describe a transgenic mouse strain that selectively express a surface marker (huCD25) on transitional B cells, pre-B cells and a lineage unidentified bone marrow (BM) population. We show that a subpopulation of B cells in Peyer's patches, spleen,
Publikováno v:
The Biochemical journal. 354(Pt 2)
Immunoglobulin (Ig)-kappa promoters from humans and mice share conserved sequences. The octamer element is common to all Ig promoters and pivotal for their function. However, other conserved sequence motifs, that differ between Ig variable gene famil
Publikováno v:
Biological chemistry. 381(11)
The GAGA box of the rat serine protease inhibitor 2 (spi 2) genes not only acts as a basal promoter element, but also mediates transcriptional activation by growth hormone and interleukin-6. The GAGA box is separated from the TATA box by only 12 bp,
Publikováno v:
The Journal of biological chemistry. 273(30)
A protein interacting with an A-T-rich region that is a positive control element within the SP6 kappa promoter was purified and identified as CArG-box binding factor-A. The purified protein was shown to interact specifically with the coding strand of
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(8)
By mutational analysis of the octamer-TATA box intervening region in the mouse SP6 kappa promoter, we have mapped two octamer-dependent, costimulatory regions, A and B. The A region was active in late B cells only, while the B region was active throu
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(10)
A conserved sequence element situated between the decamer and TATA box in V kappa II and V kappa V promoters has a high homology to the binding site for early B cell factor (EBF). The kappa promoter element was shown to bind EBF specifically using bo
Publikováno v:
Leukemia. 8(7)
Co-transfection of expression vectors for c-myc or myn down-regulated the expression from a reporter plasmid containing the chloramphenicol-acetyl-transferase (CAT) gene, under the control of an immunoglobulin kappa promoter and the immunoglobulin he
Autor:
T, Leanderson, E, Högbom
Publikováno v:
Experimental and clinical immunogenetics. 8(2)
B lymphocytes express membrane-bound immunoglobulin molecules as antigen-specific, clonally distributed, cell surface receptors. Molecules with the same fine specificity can be secreted in large amounts into the body fluids by progeny of the clone, s
Publikováno v:
Leukemia. 4(9)
The human B-lymphoma cell lines BJAB and Daudi, as well as the human pre-B cell line KM3, were found to down-regulate steady-state immunoglobulin RNA levels 2- to 4-fold after stimulation with phorbol 12-myristate-13-acetate (PMA) for 24 hr. No down-