Zobrazeno 1 - 10
of 321
pro vyhledávání: '"T. Le Doan"'
Publikováno v:
International Journal of Pharmaceutics. 331:148-152
In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c09f1638cd4271833b9f2f87644db1
https://doi.org/10.1016/j.ijpharm.2006.10.031
https://doi.org/10.1016/j.ijpharm.2006.10.031
Publikováno v:
International Journal of Pharmaceutics. 324:37-42
Nucleoside analogues are widely used in the treatment of various viral infections. However, the poor in vivo conversion of the nucleoside analogues like azidothymidine (AZT) into their active triphosphate nucleotide counterpart limits their pharmacol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476f101a4f0e4558c4ffd3b910057246
https://doi.org/10.1016/j.ijpharm.2006.07.006
https://doi.org/10.1016/j.ijpharm.2006.07.006
Publikováno v:
Archives of Physiology and Biochemistry. 111:265-272
Antisense oligonucleotides (ODN) are potent molecules that could be used to inhibit the synthesis of a protein specifically if delivered to the appropriate compartments (cytoplasm and nucleus) of the cell under study. We present here a simple method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af367b2c1aabab49bfd191f1f05a534e
https://doi.org/10.1076/apab.111.3.265.23465
https://doi.org/10.1076/apab.111.3.265.23465
Publikováno v:
Pharmaceutical Research. :441-449
Adsorption of oligothymidylates on polyisobutyl- or polyisohexylcyanoacrylate nanoparticles was achieved in the presence of hydrophobic cations such as tetraphenylphosphonium chloride or quaternary ammonium salts. Results suggested that oligonucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d720337dec31d78609bfdbe79af5cdd
https://doi.org/10.1023/a:1015871809313
https://doi.org/10.1023/a:1015871809313
Publikováno v:
Antisense Research and Development. 1:43-54
Oligopyrimidines covalently linked to ellipticine derivatives form duplex and triplex structures with target single-stranded oligopurine sequences. They also bind to duplex DNA at homopurine-homopyrimidine sequences where they form local triple helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6166c8ea92fc41ff20ebaf7092f28f1e
https://doi.org/10.1089/ard.1991.1.43
https://doi.org/10.1089/ard.1991.1.43
Publikováno v:
Bioconjugate Chemistry. 1:350-356
Development of the antisense oligonucleotide strategy for the regulation of gene expression in vivo poses several problems: the stability of oligonucleotides toward intracellular nucleases, labeling of oligonucleotides with high specific radioactivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0fb3cb5eea575c7a24b7693191b4ec
https://doi.org/10.1021/bc00005a009
https://doi.org/10.1021/bc00005a009
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 67(2-3)
The feasibility of topical delivery in the skin of 3' end modified phosphodiester oligonucleotides using electroporation was investigated. Experiments were performed in vitro, using hairless rat skin. Five pulses of (200 V, 450 ms) were applied. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4278dfd884957ff6e38d231365c5d04e
https://pubmed.ncbi.nlm.nih.gov/10825565
https://pubmed.ncbi.nlm.nih.gov/10825565
Autor:
Christian Rivalle, Ulysse Asseline, Carine Giovannangeli, T. Le Doan, Loïc Perrouault, Claude Hélène, E. Bisagni, Nguyen Thanh Thuong
Publikováno v:
Nature. 344:358-360
Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d9a170a58f7f6b955b37ab956f1494
https://doi.org/10.1038/344358a0
https://doi.org/10.1038/344358a0
Publikováno v:
Journal of drug targeting. 5(4)
Electroporation, using high voltage electrical pulses has been recognized as a powerful method for delivering macromolecules such as DNA and proteins in cells, or smaller molecules through the skin. Transdermal electroporation could combine targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cb499c260ef0f428486dc8fb8358a3
https://pubmed.ncbi.nlm.nih.gov/9713977
https://pubmed.ncbi.nlm.nih.gov/9713977
Publikováno v:
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 320(6)
Antisense oligonucleotides are currently used for the specific control of the expression of a selected gene. Their putative targets are located in the cytoplasm (messenger RNA) or the nucleus (pre-messenger RNA or DNA). This approach is conditioned b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7803a79be5e9bb90c2bd0c6e4598731
https://pubmed.ncbi.nlm.nih.gov/9247027
https://pubmed.ncbi.nlm.nih.gov/9247027