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Akademický článek

A Generalized Information-Theoretic Framework for the Emergence of Hierarchical Abstractions in Resource-Limited Systems

Autor: Daniel T. Larsson, Dipankar Maity, Panagiotis Tsiotras

Publikováno v: Entropy, Vol 24, Iss 6, p 809 (2022)

In this paper, a generalized information-theoretic framework for the emergence of multi-resolution hierarchical tree abstractions is developed. By leveraging ideas from information-theoretic signal encoding with side information, this paper develops

Externí odkaz: https://doaj.org/article/67c3b696de164aad94fce14c0b80f2c9

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Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

Publikováno v: Neuro-Oncology.

Background Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6039c6fd8a56c7fa88ceae08ddd8c926
https://doi.org/10.1093/neuonc/noad097

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Supplementary Data from Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Autor: Branden S. Moriarity, David A. Largaespada, Eric P. Rahrmann, Wendy A. Hudson, Margaret R. Crosby, Lauren J. Mills, Susan K. Rathe, Juan E. Abrahante, Joseph J. Peterson, Kanut Laoharawee, Kyle B. Williams, Kenta Yamamoto, Kelsie L. Becklin, Emily J. Pomeroy, Natalie Stratton, Alex T. Larsson, Nicholas J. Slipek, Garrett M. Draper, Branden A. Smeester

Supplementary data for Smeester et al.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926e61d461be2c0d40bf83b6375393d
https://doi.org/10.1158/1535-7163.22521444.v1

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Table S2 from Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

List of all DEGs identified in transient ZNF217 knockdown versus control SJSA-1 OSA cells with associated fold changes and FDR-adjusted p values.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7498558170065e3b7ce8a004ecc5954d
https://doi.org/10.1158/1535-7163.22521438

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Data from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebcfc7720d1848ea19440c3e7a8f431f
https://doi.org/10.1158/0008-5472.c.6511413.v1

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Supplementary Figures 4-7 from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Figure S4. Shows ARHGAP36 expression in mouse and human neural tissue. Figure S5. Shows characterization of ARHGAP36 and Megf10 in C17.2 cells Figures S6-S7 show mechanistic analysis of FOXR2 in C17.2 and HSC1L cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88fb8090e9d0f93c8d64bec0f20df6
https://doi.org/10.1158/0008-5472.22423053

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Supplementary Figures 1-3 from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Characterization of SB-induced medulloblastomas and CNS-PNETs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcf71417a72492031f7dbb0484851a0
https://doi.org/10.1158/0008-5472.22423056.v1

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CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

Autor: Jiawan Wang, Ana Calizo, Lindy Zhang, James C. Pino, Yang Lyu, Kai Pollard, Xiaochun Zhang, Alex T. Larsson, Eric Conniff, Nicolas Llosa, David K. Wood, David A. Largaespada, Susan E. Moody, Sara J. Gosline, Angela C. Hirbe, Christine A. Pratilas

Publikováno v: bioRxiv

Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft tissue sarcomas with limited treatment options, and novel effective therapeutic strategies are desperately needed. We observe anti-proliferative efficacy of genetic depletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b141123c1fa8090bf92f019ef2924b2
https://doi.org/10.1101/2023.02.02.526674

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Information-Theoretic Abstractions for Planning in Agents With Computational Constraints

Autor: Panagiotis Tsiotras, Daniel T. Larsson, Dipankar Maity

Publikováno v: IEEE Robotics and Automation Letters. 6:7651-7658

In this paper, we develop a framework for path-planning on abstractions that are not provided to the agent a priori but instead emerge as a function of the available computational resources. We show how a path-planning problem in an environment can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56614b5e3fb4cf5da53f6ad7dfc9177
https://doi.org/10.1109/lra.2021.3099995

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