Zobrazeno 1 - 10
of 19
pro vyhledávání: '"T. L. Mccarthy"'
Autor:
P. White, J. C. Fox, C. R. Newton, J. M. A. Northover, Ian C. Talbot, D. Snary, J. Smith-Ravin, T. L. Mccarthy, N. R. Charlesworth, K. Callaghan, S. Little, G. Ellison, J. England, J. Hehir
Publikováno v:
British Journal of Cancer
A total of 301 colorectal carcinoma (CRC) archival samples were analysed using the amplification-refractory mutation system (ARMS). Each sample was examined to determine the mutation status of codons 12 and 13 of the K-ras oncogene. The results from
Autor:
T. L. McCarthy
Publikováno v:
Endocrinology. 130:1303-1308
Publikováno v:
Molecular and Cellular Biology. 10:4473-4479
We have recently cloned the cDNA for transforming growth factor type beta 3 (TGF-beta 3), a new member of the TGF-beta gene family. We examined the biological effects of recombinant TGF-beta 3 protein in osteoblast-enriched bone cell cultures. In thi
Publikováno v:
Endocrinology. 141(1)
Glucocorticoid has complex effects on osteoblasts. Several of these changes appear to be related to steroid concentration, duration of exposure, or specific effects on growth factor expression or activity within bone. One important bone growth factor
Publikováno v:
The Journal of biological chemistry. 274(43)
Transforming growth factor-beta binds to three high affinity cell surface molecules that directly or indirectly regulate its biological effects. The type III receptor (TRIII) is a proteoglycan that lacks significant intracellular signaling or enzymat
Publikováno v:
Endocrinology. 140(10)
Insulin-like growth factor (IGF)-binding protein-5 (IGFBP-5) has IGF-dependent and -independent actions. PGE2 rapidly increases IGFBP-5 expression by osteoblasts through cAMP-dependent processes. A minimal DNA sequence required for basal and PGE2-sti
Autor:
C, Ji, S, Casinghino, D J, Chang, Y, Chen, A, Javed, Y, Ito, S W, Hiebert, J B, Lian, G S, Stein, T L, McCarthy, M, Centrella
Publikováno v:
Journal of cellular biochemistry. 69(3)
Organization of the transforming growth factor-beta (TGF-beta) type I receptor (TRI) promoter predicts constitutive transcription, although its activity increases with differentiation status in cultured osteoblasts. Several sequences in the rat TRI p
Publikováno v:
Frontiers in bioscience : a journal and virtual library. 3
Bone growth and remodeling are controlled by local and systemic growth factors. The first local bone growth factor purified to homogeneity was transforming growth factor type beta (TGF-beta). On skeletal cells, TGF-beta has multiple effects mediated
Publikováno v:
The Journal of biological chemistry. 272(50)
Insulin-like growth factor-I (IGF-I) plays a key role in skeletal growth by stimulating bone cell replication and differentiation. We previously showed that prostaglandin E2 (PGE2) and other cAMP-activating agents enhanced IGF-I gene transcription in
Publikováno v:
Journal of cellular biochemistry. 67(4)
Glucocorticoid in excess produces bone loss in vivo. Consistent with this, it reduces the stimulatory effect of transforming growth factor beta (TGF-beta) on collagen synthesis in osteoblast-enriched cultures in vitro, where it also suppresses TGF-be