Výsledky vyhledávání

The yeast RNA polymerase I promoter: ribosomal DNA sequences involved in transcription initiation and complex formation inin vitro

Autor: D L Riggs, J D Heck, M Nomura, R J Planta, T Kulkens

Publikováno v: Nucleic Acids Research. 19:5363-5370

Using an in vitro transcription system for Saccharomyces cerevisiae RNA polymerase I, we have analyzed Pol I promoter deletion mutants and mapped the boundaries of the promoter between positions -155 and +27. The 5'-boundary of the minimal core promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799c36db21baca062058f87beaec7d49
https://doi.org/10.1093/nar/19.19.5363

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Two divergent types of nerve pathology in patients with different P0 mutations in Charcot-Marie-Tooth disease

Autor: T. Kulkens, Frans G. I. Jennekens, Eva Nelis, E.C.M. Mariman, B.G.M. van Engelen, M. de Visser, Fons J. M. Gabreëls, P.H.S. Meijerink, C. Van Broeckhoven, S.E.C. van Beersum, Pieter A. Bolhuis, Jessica E. Hoogendijk, A.A.W.M. Gabreëls-Festen

Publikováno v: Neurology, 47, 761-765
Neurology, 47, 3, pp. 761-765
Neurology
Neurology, 47, pp. 761-765
Neurology, 47(3), 761-765. Lippincott Williams and Wilkins

In seven unrelated patients with a demyelinating motor and sensory neuropathy, we found mutations in exons 2 and 3 of the P sub 0 gene.Morphologic examination of sural nerve biopsy specimens showed a demyelinating process with onion bulb formation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8500e70a68cea21fe3b2b885c516ff7b
http://hdl.handle.net/2066/120899

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A system to study transcription by yeast RNA polymerase I within the chromosomal context: functional analysis of the ribosomal DNA enhancer and the RBP1/REB1 binding sites

Autor: A. F. Dekker, H van Heerikhuizen, T. Kulkens, C. A. F. M. Van Der Sande, Rudi J. Planta

We have developed a novel system to study transcription by yeast RNA polymerase I (Pol I) of mutated rDNA units within the chromosomal context. For this, complete rDNA units carrying specific oligonucleotide tags in both the 17S and 26S rRNA genes we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3a74e8031115274d7317187d1b3248
https://europepmc.org/articles/PMC557042/

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Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives

Autor: Alexander J. Debets, T Kulkens, J. de Vries, R. Van De Straat, Nico P. E. Vermeulen

Publikováno v: Biochemical Pharmacology. 35:3693-3699

The effects of 3-monoalkyl- and 3,5-dialkyl-substitution on the cytotoxicity of paracetamol (PAR) in rat hepatocytes was studied. PAR is known to be bioactivated by the hepatic microsomal cytochrome P-450 containing a mixed-function oxidase system pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29f4d4d5f69e16a5a74510312034eecf
https://doi.org/10.1016/0006-2952(86)90653-2

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Termination of transcription by yeast RNA polymerase I

Autor: H van Heerikhuizen, Rudi J. Planta, C. A. F. M. Van Der Sande, A.B. Kramer, Jacobus Klootwijk, T. Kulkens, I. J. De Wijs

Publikováno v: Nucleic Acids Research. 17:9127-9146

Analysis of the termination of transcription by yeast RNA polymerase I (Pol I) using in vitro run-on experiments in both isolated nuclei and permeabilized cells demonstrated that Pol I does not traverse the whole intergenic spacer separating consecut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b680c7a81f679b3f716827ef051dabe3
https://doi.org/10.1093/nar/17.22.9127

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Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes

Autor: R, Van De Straat, J, De Vries, T, Kulkens, A J, Debets, N P, Vermeulen

Publikováno v: Biochemical pharmacology. 35(21)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ed3ef94f958830cfc9593b1bfc2d123
https://pubmed.ncbi.nlm.nih.gov/3778500

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A yeast ribosomal DNA-binding protein that binds to the rDNA enhancer and also close to the site of Pol I transcription initiation is not important for enhancer functioning

Autor: Rudi J. Planta, H van Heerikhuizen, J. Oliemans, T. Kulkens, Jacobus Klootwijk

Publikováno v: Current genetics. 16(5-6)

Using the gel retardation assay we have identified a protein that can specifically bind to a site within the enhancer of the 37S pre-ribosomal RNA operon in yeast, as well as to a site 210 bp upstream of the site of transcription initiation of this o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b484ddf9a1457162ca592771b4c5c3
https://pubmed.ncbi.nlm.nih.gov/2692853

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