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Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature

Publikováno v: Breast cancer research and treatment, 194(2), 265-278. Springer New York
Breast cancer research and treatment
Breast Cancer Research and Treatment, 194(2), 265-278. Springer New York
Opdam, M, van der Noort, V, Kleijn, M, Glas, A, Mandjes, I, Kleiterp, S, Hilbers, F S, Kruger, D T, Bins, A D, de Jong, P C, Schiphorst, P P J B M, van Dalen, T, Flameling, B, Rietbroek, R C, Beeker, A, van den Heiligenberg, S M, Bakker, S D, Wymenga, A N M, Oving, I M, Bijlsma, R M, van Diest, P J, Vermorken, J B, van Tinteren, H & Linn, S C 2022, ' Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature ', Breast Cancer Research and Treatment, vol. 194, no. 2, pp. 265-278 . https://doi.org/10.1007/s10549-022-06618-z

Purpose Guidelines recommend endocrine treatment for estrogen receptor-positive (ER+) breast cancers for up to 10 years. Earlier data suggest that the 70-gene signature (MammaPrint) has potential to select patients that have an excellent survival wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff14e4330cdee35c7a55ca1f5f2e824
https://doi.org/10.1007/s10549-022-06618-z

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PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane

Autor: Dinja T. Kruger, Karin Beelen, Vincent van der Noort, Sabine C. Linn, Joyce Sanders, Epie Boven, Mark Opdam, Bart de Valk, Michiel Nieuwenhuis

Publikováno v: Journal of Cancer Research and Clinical Oncology
Kruger, D T, Opdam, M, van der Noort, V, Sanders, J, Nieuwenhuis, M, de Valk, B, Beelen, K J, Linn, S C & Boven, E 2020, ' PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane ', Journal of Cancer Research and Clinical Oncology, vol. 146, no. 11, pp. 3013-3023 . https://doi.org/10.1007/s00432-020-03291-x
Journal of Cancer Research and Clinical Oncology, 146(11), 3013-3023. Springer Verlag

Purpose Everolimus plus exemestane (EVE/EXE) is a registered treatment option for ER-positive, HER2-negative (ER +/HER2-) metastatic breast cancer (MBC), but resistance mechanisms limit efficacy. We aimed to find markers that might help select patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a57315afaf23040348c87692a37d13
http://www.scopus.com/inward/record.url?scp=85086852955&partnerID=8YFLogxK

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High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2− postmenopausal breast cancer patients treated with everolimus and exemestane

Autor: Wouter Dercksen, Dinja T. Kruger, Agnes Jager, Inge R. H. M. Konings, John W.M. Martens, Maurice P.H.M. Jansen, Jamal Oulad Hadj, Stefan Sleijfer, Epie Boven

Publikováno v: Molecular Oncology, Vol 14, Iss 3, Pp 490-503 (2020)
Molecular Oncology, 14, 490-503. John Wiley & Sons Ltd.
Kruger, D T, Jansen, M P H M, Konings, I R H M, Dercksen, W M, Jager, A, Oulad Hadj, J, Sleijfer, S, Martens, J W M & Boven, E 2020, ' High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2-postmenopausal breast cancer patients treated with everolimus and exemestane ', Molecular oncology, vol. 14, no. 3, pp. 490-503 . https://doi.org/10.1002/1878-0261.12617
Molecular Oncology
Molecular oncology, 14(3), 490-503. Elsevier

We determined whether progression-free survival (PFS) in metastatic breast cancer (MBC) patients receiving everolimus plus exemestane (EVE/EXE) varies depending on circulating tumour DNA (ctDNA) characteristics. Baseline plasma cell-free DNA (cfDNA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5c0a1cb359458c8b803600178dc633
https://doaj.org/article/131bba09d28a4cc7af7300b46f189229

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Navigating authority and legitimacy when ‘outsider’ volunteers co-produce emergency management services

Autor: T Kruger, Blythe McLennan, Joshua Whittaker, John Handmer

Publikováno v: Environmental Hazards. 20:7-22

This paper examines the thorny issue of authority and legitimacy in relation to ‘outsider’ emergency volunteering within the context of the community resilience policy agenda. Outsider emer...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::423a3ba3f782778fe9ae7f0dca8b79f6
https://doi.org/10.1080/17477891.2020.1727829

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Deep Brain Stimulation for Spasmodic Dysphonia: A Phase I Randomized Controlled Trial

Autor: Christopher R. Honey, Marie T. Kruger, Timoteo Almeida, Linda A. Rammage, Mandeep S. Tamber, Murray D. Morrison, Anujan Poologaindran, Amanda Hu

Publikováno v: Neuromodulation: Technology at the Neural Interface. 25:S10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cae347065b56c7452d7554a53d9c784d
https://doi.org/10.1016/j.neurom.2022.04.017

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A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function

Autor: Hiddo J.L. Heerspink, David Cherney, Douwe Postmus, Bergur V. Stefánsson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John J.V. McMurray, Ricardo Correa-Rotter, Peter Rossing, C. David Sjöström, Robert D. Toto, David C. Wheeler, Glenn Chertow, Fan Fan Hou, John McMurray, Robert Toto, Bergur Stefansson, L.E. Maffei, P. Raffaele, S.E. Solis, C.A. Arias, D. Aizenberg, C. Luquez, C. Zaidman, N. Cluigt, M. Mayer, A. Alvarisqueta, A. Wassermann, R. Maldonado, J. Bittar, M. Maurich, L.E. Gaite, N. Garcia, L. Sivak, P.O. Ramallo, J.C. Santos, R. Garcia Duran, J.A. Oddino, A. Maranon, L.N. Maia, D.D. Avila, E.J.G. Barros, M.H. Vidotti, D. Panarotto, I.D.L. Noronha, L.A.A. Turatti, L. Deboni, M.E. Canziani, M.C. Riella, M.R. Bacci, R.P. Paschoalin, R.J. Franco, J.C. Goldani, E. St-Amour, A.W. Steele, R. Goldenberg, S. Pandeya, H. Bajaj, D. Cherney, S.M. Kaiser, J.R. Conway, S.S. Chow, G. Bailey, J. Lafrance, J. Winterstein, S. Cournoyer, D. Gaudet, F. Madore, R.L. Houlden, A. Dowell, M. Langlois, N. Muirhead, H. Khandwala, A. Levin, F. Hou, Y. Xue, L. Zuo, C. Hao, Z. Ni, C. Xing, N. Chen, Y. Dong, R. Zhou, X. Xiao, Y. Zou, C. Wang, B. Liu, Q. Chen, M. Lin, Q. Luo, D. Zhang, J. Wang, M. Chen, X. Wang, A. Zhong, J. Dong, C. Zhu, T. Yan, P. Luo, Y. Ren, P. Pai, D. Li, R. Zhang, J. Zhang, M. Xu, Y. Zhuang, Y. Kong, X. Yao, X. Peng, F.I. Persson, T.K. Hansen, R. Borg, U. Pedersen Bjergaard, D. Hansen, M. Hornum, H. Haller, G. Klausmann, D. Tschope, T. Kruger, P. Gross, C. Hugo, N. Obermuller, L. Rose, P. Mertens, H. Zeller-Stefan, A. Fritsche, L. Renders, J. Muller, K. Budde, B. Schroppel, I. Wittmann, P. Voros, M. Dudas, G.A. Tabak, R. Kirschner, A. Letoha, I. Balku, Z. Hermanyi, G. Zakar, I. Mezei, G.G. Nagy, J. Lippai, A. Nemeth, D. Khullar, P.K. Gowdaiah, E. Fernando Mervin, V.A. Rao, D. Dewan, K. Goplani, V.S.K. Maddi, M.S. Vyawahare, R.K. Pulichikkat, R. Pandey, S.K. Sonkar, V.K. Gupta, S. Agarwal, A.J. Asirvatham, A. Ignatius, S. Chaubey, S. Melemadathil, H. Alva, Y. Kadam, H. Shimizu, A. Sueyoshi, H. Takeoka, Y. Abe, T. Imai, Y. Onishi, Y. Fujita, Y. Tokita, M. Oura, Y. Makita, A. Idogaki, R. Koyama, H. Kikuchi, N. Kashihara, T. Hayashi, Y. Ando, T. Tanaka, M. Shimizu, S. Hidaka, T. Gohda, K. Tamura, M. Abe, Y. Kamijo, T. Imasawa, Y. Takahashi, M. Nakayama, M. Tomita, F. Hirano, Y. Fukushima, A. Kiyosue, S. Kurioka, E. Imai, K. Kitagawa, M. Waki, J. Wada, K. Uehara, H. Iwatani, K. Ota, S. Shibazaki, K. Katayama, I. Narita, M. Iinuma, S. Matsueda, S. Sasaki, A. Yokochi, T. Tsukamoto, T. Yoshimura, S. Kang, S. Lee, C.S. Lim, H. Chin, K.W. Joo, S.Y. Han, T.I. Chang, S. Park, H. Park, C.W. Park, B.G. Han, D.R. Cha, S.A. Yoon, W. Kim, S.W. Kim, D. Ryu, R. Correa Rotter, S.S. Irizar Santana, G. Hernandez Llamas, R. Valdez Ortiz, N.C. Secchi Nicolas, G. Gonzalez Galvez, J.R. Lazcano Soto, T. Bochicchio Riccardelli, E.A. Bayram Llamas, D.R. Ramos Ibarra, M.G.S. Melo, J.G. Gonzalez Gonzalez, J.H. Sanchez Mijangos, M. Madero Robalo, A. Garcia Castillo, H.A. Manrique, J.C. Farfan, R. Vargas, A. Valdivia, A. Dextre, E. Escudero, J.R. Calderon Ticona, L. Gonzales, J. Villena, L. Leon, G. Molina, A. Saavedra, E. Garrido, H. Arbanil, S. Vargas Marquez, J. Rodriguez, R. Isidto, A.J. Villaflor, M.A. Gumba, L. Tirador, R.S. Comia, R.A. Sy, M.L.V.V. Guanzon, G. Aquitania, N.C. De Asis, A.A. Silva, C.M. Romero, M.E. Lim, R.A. Danguilan, M. Nowicki, H. Rudzki, K. Landa, I. Kucharczyk-Bauman, B. Gogola-Migdal, M. Golski, A. Olech-Cudzik, T. Stompor, T. Szczepanik, B. Miklaszewicz, R. Sciborski, M. Kuzniewski, K. Ciechanowski, D. Wronska, W. Klatko, S. Mazur, G. Popenda, M. Myslicki, L.Z. Bolieva, S. Berns, A. Galyavich, T. Abissova, I. Karpova, D. Platonov, N. Koziolova, L. Kvitkova, R. Nilk, T. Medina, A. Rebrov, M. Rossovskaya, I. Sinitsina, E. Vishneva, N. Zagidullin, T. Novikova, N. Krasnopeeva, O. Magnitskaya, N. Antropenko, M. Batiushin, V. Escudero Quesada, C. Barrios Barrea, E. Espinel Garauz, J.M. Cruzado Garrit, C. Morales Portillo, J.L. Gorriz Teruel, S. Cigarran Guldris, M. Praga Terente, N.R. Robles Perez-Monteoliva, F.J. Tinahones Madueno, A. Soto Gonzalez, C. Diaz Rodriguez, H. Furuland, A. Saeed, K. Dreja, J. Spaak, A. Bruchfeld, M. Kolesnyk, O. Levchenko, N. Pyvovarova, V. Stus, V. Doretskyy, N. Korobova, O. Horoshko, I. Katerenchuk, Y.M. Mostovoy, M. Orynchak, O. Legun, I. Dudar, O. Bilchenko, S. Andreychyn, A. Levchenko, L. Zub, N. Tereshchenko, I. Topchii, T. Ostapenko, S. Bezuglova, M. Kopytsya, O. Turenko, P. Mark, J. Barratt, S. Bhandari, D. Fraser, P. Kalra, S.P. Kon, K. Mccafferty, A. Mikhail, O.P. Alvarado, R. Anderson, N.S. Andrawis, A. Arif, S.A. Benjamin, G. Bueso, R.S. Busch, K.W. Carr, P. Crawford, N. Daboul, G.M. De La Calle, B. Delgado, J. Earl, M.A. El-Shahawy, R.J. Graf, G. Greenwood, A. Guevara, E.M. Wendland, R.K. Mayfield, M. Montero, D.J. Morin, P. Narayan, V. Numrungroad, A.C. Reddy, R. Reddy, M.B. Samson, R. Trejo, M.B. Butcher, J.K. Wise, L.R. Zemel, M. Raikhel, D. Weinstein, P. Hernandez, A. Wynne, B.V. Khan, G.A. Sterba, A. Jamal, D. Ross, S.F. Rovner, A. Tan, F. Ovalle, R.J. Patel, J. Talano, D.R. Patel, A. Burgner, N. Aslam, M. Elliott, S. Goral, A. Jovanovich, J.A. Manley, K. Umanath, D. Waguespack, D. Weiner, M. Yu, L. Schneider, D. Jalal, T. Le, N. Nguyen, H. Nguyen, D. Nguyen, V. Nguyen, T. Do, P. Chu, D. Ta, N. Tran, B. Pham, Marc A. Pfeffer, Stuart Pocock, Karl Swedberg, Jean L. Rouleau, Nishi Chaturvedi, Peter Ivanovich, Andrew S. Levey, Heidi Christ-Schmidt, Claes Held, Christina Christersson, Johannes Mann, Christoph Varenhorst

Publikováno v: Heerspink, H J L & DAPA-CKD Trial Committees and Investigators 2022, ' A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function ', Kidney International, vol. 101, no. 1, pp. 174-184 . https://doi.org/10.1016/j.kint.2021.09.005
Kidney International, 101(1), 174-184. ELSEVIER SCIENCE INC

This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high-risk patients based on having chronic kidney disease (CKD) and substantial albuminuria. DAPA-CKD wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e897f3e52e183420385f2efa855cd2ee
https://pubmed.ncbi.nlm.nih.gov/34991813

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Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes

Autor: Epie Boven, Joyce Sanders, Dinja T. Kruger, Vincent van der Noort, Mark Opdam, Sabine C. Linn

Publikováno v: Kruger, D T, Opdam, M, Sanders, J, van der Noort, V, Boven, E & Linn, S C 2020, ' Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes ', APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, vol. 128, no. 4, pp. 298-307 . https://doi.org/10.1111/apm.13026
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 128(4), 298-307. Wiley-Blackwell
Apmis

The phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase(MAPK) pathways are frequently activated in breast cancer. We recently demonstrated the importance of analyzing multiple proteins as read-out for pathway activation in ER+/H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e2f1ab13db8dab9a711a8343effcf6
https://research.vumc.nl/en/publications/573f888c-960a-4479-bbde-68a0e74a0091

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