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pro vyhledávání: '"T. K. Sawyer"'
This review focuses on some of the latest approaches to developing small molecule, peptide, and antibody therapeutics as inhibitors of intracellular protein–protein interactions (PPIs). While distinct, each class of therapeutics relies on identifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24d7947921693b184c9f48e53796d14
https://doi.org/10.1039/9781839160677-00066
https://doi.org/10.1039/9781839160677-00066
Publikováno v:
The Journal of Peptide Research. 66:312-318
As the last of a trilogy of special tribute series honoring Editor-in-Chief Victor J. Hruby, this final published issue of the Journal of Peptide Research includes a collection of congratulatory wishes and special commentaries (vide infra) from a wid
Autor:
T K, Sawyer, W C, Shakespeare, Y, Wang, R, Sundaramoorthi, W-S, Huang, C A, Metcalf, M, Thomas, B M, Lawrence, L, Rozamus, J, Noehre, X, Zhu, S, Narula, R S, Bohacek, M, Weigele, D C, Dalgarno
Publikováno v:
Medicinal Chemistry. 1:293-319
Protein phosphorylation has been exploited by Nature in profound ways to control various aspects of cell proliferation, differentiation, metabolism, survival, motility and gene transcription. Cellular signal transduction pathways involve protein kina
Autor:
T. K. Sawyer, Michael Chorev
Publikováno v:
BioTechniques. 34:594-599
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 20:139-143
To evaluate the effects of regular flushing, water from fifty emergency eyewash and shower stations was cultured for the presence of potentially pathogenic protozoa, heterotrophic bacteria, and Legionella species. This study also provided the opportu
Autor:
K S, Para, T K, Sawyer
Publikováno v:
Methods in molecular medicine. 23
Aminobenzoic acid-based congeners are emerging as a useful class of nonpeptide templates for applications in peptidomimetic drug discovery. Exemplifying such compounds are recently described antagonists or inhibitors of several receptor and signal tr
Publikováno v:
Current opinion in drug discoverydevelopment. 3(5)
Signal transduction targets include catalytic and/or non-catalytic domains, which are critical to various aspects of cell growth, differentiation, metabolism and function, mitogenesis, motility and gene transcription. Specific examples of molecular t
Publikováno v:
Applied and Environmental Microbiology. 57:163-167
Forty eyewash units were sampled for protozoa, bacteria, and fungi. Total heterotrophic bacterial counts on nutrient agar and R2A agar (Difco Laboratories, Detroit, Mich.) ranged from 0 to 10(5) CFU/ml, with Pseudomonas spp. being the most frequently
Autor:
T K, Sawyer
Publikováno v:
Biopolymers. 47(3)
Src homology-2 (SH2) domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Such SH2 proteins are found in the regulation of a number of cellular processes, including growth
Autor:
M E, Hadley, V J, Hruby, J, Blanchard, R T, Dorr, N, Levine, B V, Dawson, F, al-Obeidi, T K, Sawyer
Publikováno v:
Pharmaceutical biotechnology. 11