Zobrazeno 1 - 10
of 161
pro vyhledávání: '"T. K. Harden"'
Publikováno v:
Acta Physiologica. 199:149-160
The P2Y14 receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89bd637fdaeaa1056471068966ba9c29
https://doi.org/10.1111/j.1748-1716.2010.02116.x
https://doi.org/10.1111/j.1748-1716.2010.02116.x
Publikováno v:
Journal of Thrombosis and Haemostasis. 4:861-868
Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. We recently described the synthesis and P2Y1 receptor-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b521bb6f86bb1df321b7198b5dafaf59
https://doi.org/10.1111/j.1538-7836.2006.01866.x
https://doi.org/10.1111/j.1538-7836.2006.01866.x
Autor:
Anna-Karin Wihlborg, V. E. Marquez, Kenneth A. Jacobson, Savitri Maddileti, David Erlinge, Malin Malmsjö, T K Harden, RG Ravi, Hak Sung Kim, José L. Boyer
Publikováno v:
Journal of Medicinal Chemistry. 45:208-218
The potency of nucleotide antagonists at P2Y(1) receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829842). We have now synthesized ring-constrained methanocarba analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8262a7a7f15c7285469ba9e9037e7f
https://doi.org/10.1021/jm010369e
https://doi.org/10.1021/jm010369e
Publikováno v:
Journal of Receptors and Signal Transduction. 21:167-190
The discovery of cyclic AMP by Sutherland and Rall [1] in 1956 provided the initial impetus from which the scaffolding of drug receptor pharmacology with the discipline of physiology was extended t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1960515e07474812458c7db66f9c45
https://doi.org/10.1081/rrs-100107427
https://doi.org/10.1081/rrs-100107427
Autor:
Yong-Chul Kim, José L. Boyer, George R. Dubyak, Geoffrey Burnstock, Brian F. King, T K Harden, Sean G. Brown, Kenneth A. Jacobson
Publikováno v:
Journal of Medicinal Chemistry. 44:340-349
Novel analogues of the P2 receptor antagonist pyridoxal-5'-phosphate 6-azophenyl-2',5'-disulfonate (2) were synthesized and studied as antagonists in functional assays at recombinant rat P2X1, P2X2, and P2X3 receptors expressed in Xenopus oocytes (io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd014b5d20836623128206708bfbb5b5
https://doi.org/10.1021/jm9904203
https://doi.org/10.1021/jm9904203
Publikováno v:
Biochemical Journal. 338:257-264
The potential role of protein kinase C (PKC)-promoted phosphorylation has been examined in the G-protein-regulated inositol lipid signalling pathway. Incubation of [32P]Pi-labelled turkey erythrocytes with either the P2Y1 receptor agonist 2-methylthi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9775136711185361652271e6797b163
https://doi.org/10.1042/bj3380257
https://doi.org/10.1042/bj3380257
Publikováno v:
Experimental Lung Research. 25:277-290
The Ca(2+)-mobilizing actions of adenosine 5'-triphosphate (ATP), bradykinin, and histamine were compared in phenotypically distinct human nasal epithelial (HNE) cell types and as a function of time in cell culture. Single-cell measurements of intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5337ced524acbcb5fbe5dc6c58fb4172
https://doi.org/10.1080/019021499270196
https://doi.org/10.1080/019021499270196
Autor:
Graeme Milligan, Joan Heller Brown, Raymond Dingledine, Stuart G. Cull-Candy, T K Harden, William A. Catterall, P.J. Conn, Paul A. Insel, Stephen F. Traynelis
Publikováno v:
Brown, JH; Catterall, WA; Conn, PJ; Cull-Candy, SG; Dingledine, R; Harden, TK; et al.(2015). The first 50 years of Molecular Pharmacology. Molecular Pharmacology, 88(1), 139-140. doi: 10.1124/mol.115.099564. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7j5708qt
Molecular pharmacology, vol 88, iss 1
Molecular pharmacology, vol 88, iss 1
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. In this Perspective, former and current editors of Molecular Pharmacology, together with the guest editors for this 50th Anniversary Issue, provide a historical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a46bff16f6197938d36c94e212787a
https://doi.org/10.1124/mol.115.099564
https://doi.org/10.1124/mol.115.099564
Autor:
BF King, Kenneth A. Jacobson, Arvind Mohanram, T K Harden, J L Boyer, Scott S.P. Wildman, Geoffrey Burnstock, Yong-Chul Kim
Publikováno v:
Journal of Medicinal Chemistry. 41:2201-2206
Analogues of the P2 receptor antagonists pyridoxal-5'-phosphate and the 6-azophenyl-2',4'-disulfonate derivative (PPADS), in which the phosphate group was cyclized by esterification to a CH2OH group at the 4-position, were synthesized. The cyclic pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c6bbd7331cb19bc8ce3260fad14842
https://doi.org/10.1021/jm980183o
https://doi.org/10.1021/jm980183o
Autor:
Qing Li, Robert A. Nicholas, William C. Watt, José L. Boyer, T. K. Harden, Eduardo R. Lazarowski
Publikováno v:
Journal of Autonomic Pharmacology. 16:319-324
1. Four different phospholipase C (PLC)-activating P2Y receptors have been cloned and stably expressed in 1321N1 human astrocytoma cells. These include the human homologues of the P2Y1, P2Y2 and P2Y4 receptors and the rat homologue of the P2Y6 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c21bca824adf15e36df19a81c7bbde
https://doi.org/10.1111/j.1474-8673.1996.tb00044.x
https://doi.org/10.1111/j.1474-8673.1996.tb00044.x