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pro vyhledávání: '"T. Joseph McKenna"'
Autor:
T. Joseph McKenna
Publikováno v:
Clinical Endocrinology. 71:466-469
Macroprolactin is a nonbioactive prolactin isoform usually composed of a monomer of prolactin and a IgG molecule which has a prolonged clearance rate similar to that of the immunoglobulins. Macroprolactinaemia, hyperprolactinaemia entirely accounted
Publikováno v:
Clinical Endocrinology. 70:599-605
Summary Objective It has been reported that macroprolactin is a complex of PRL and an immunoglobulin G (IgG). This study further characterizes macroprolactin and evaluates for other markers of autoimmunity using a cohort of macroprolactinaemic sera.
Publikováno v:
Clinical Chemistry. 54:1673-1681
Background: Macroprolactin is an important source of immunoassay interference that commonly leads to misdiagnosis and mismanagement of hyperprolactinemic patients. We used the predominant immunoassay platforms for prolactin to assay serum samples tre
Autor:
Thomas P. Smith, T. Joseph McKenna
Publikováno v:
The Endocrinologist. 18:249-254
Macroprolactin is a frequently unrecognized phenomenon giving rise to inaccurate diagnosis in an estimated 10% of cases of hyperprolactinemia in the United States. This has been associated with unnecessary investigation and inappropriate treatment in
Publikováno v:
Clinical Chemistry. 52:1366-1372
Background: Increased serum concentrations of macroprolactin are a relatively common cause of misdiagnosis and mismanagement of hyperprolactinemic patients. Methods: We studied sera from a cohort of 42 patients whose biochemical hyperprolactinemia wa
Publikováno v:
Journal of Endocrinology. 186:33-42
The capacity of the adrenal to produce steroids is controlled in part through the transcriptional regulation of steroid enzymes. The orphan nuclear receptor steroidogenic factor 1 (SF-1) is central to the transcriptional regulation of all steroid hyd
Publikováno v:
Clinical Endocrinology. 62:633-643
The anterior pituitary hormone PRL was identified in animal species as early as 1933 1 but only purified in humans in 1972. 2 Since then, the clinical syndrome of hyperprolactinaemia has been characterized extensively, the predominant symptoms being
Autor:
Abdulwahab M. Suliman, T. Joseph McKenna, Yvonne McBrinn, Thomas P. Smith, Rosemarie Freaney, James Gibney, Barbara Murray
Publikováno v:
Metabolism. 53:1251-1254
Hypoglycemia has been reported to cause suppression of parathyroid hormone (PTH) levels in serum in normal subjects. It is possible that increasing cortisol levels in response to hypoglycemia was responsible. To examine this possibility the acute PTH
Publikováno v:
The Endocrinologist. 14:133-137
Autor:
T. Joseph McKenna, Rosemarie Freaney, Barbara Murray, Thomas P. Smith, Yvonne McBrinn, Abdulwahab M. Suliman
Publikováno v:
Clinical Endocrinology. 59:380-387
Summary OBJECTIVE Optimization of physiological replacement of glucocorticoid in patients with adrenal insufficiency is controversial. The present study was undertaken to compare the relative impact of three different regimes of glucocorticoid replac