Zobrazeno 1 - 10 of 29 pro vyhledávání: '"T. Jesse Kwoh"'
1
Akademický článek
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events
Autor: Wesley Partridge, Sebastien A. Burel, Annie Ferng, Shuting Xia, T. Jesse Kwoh, Scott P. Henry, Brenda F. Baker
Publikováno v: Clinical and Translational Science, Vol 16, Iss 4, Pp 575-580 (2023)
Abstract This analysis sought to assess the clinical predictivity of an in vitro assay which utilized the human B‐lymphoma BJAB cell line, for identification of antisense oligonucleotides (ASOs) with the potential to elicit innate immune activation
Externí odkaz: https://doaj.org/article/c6738881c87b44a086e9231dab0c5d37
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2
Akademický článek
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
Autor: Maartje E. Visser, Fatima Akdim, Diane L. Tribble, Aart J. Nederveen, T. Jesse Kwoh, John J.P. Kastelein, Mieke D. Trip, Erik S.G. Stroes
Publikováno v: Journal of Lipid Research, Vol 51, Iss 5, Pp 1057-1062 (2010)
To investigate the impact of mipomersen, an apolipoprotein B-100 (apoB) synthesis inhibitor, on intra-hepatic triglyceride content (IHTG content), we conducted a randomized, double-blind, placebo-controlled study in 21 patients with familial hypercho
Externí odkaz: https://doaj.org/article/7fb37859a98b45d9af60f82c26572d08
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4
Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods
Autor: Brenda F. Baker, Shuting Xia, Wesley Partridge, Richard S. Geary, Sanjay Bhanot, T. Jesse Kwoh
Publikováno v: Nucleic Acid Therapeutics
The development process of antisense oligonucleotides (ASOs) as therapeutic agents in humans has advanced through the implementation of chemical compound modifications as well as increasingly sophisticated toxicological preclinical screening techniqu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a15be03ddcace5a4a9c8c879eb0520
https://doi.org/10.1089/nat.2020.0917
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5
Integrated Assessment of Phase 2 Data on GalNAc
Autor: Brenda F, Baker, Shuting, Xia, Wesley, Partridge, T Jesse, Kwoh, Sotirios, Tsimikas, Sanjay, Bhanot, Richard S, Geary
Publikováno v: Nucleic acid therapeutics.
Receptor-mediated delivery of an antisense oligonucleotide (ASO) using the ligand-conjugated antisense technology is establishing a new benchmark for antisense therapeutics. The triantennary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cac4ff6aa3549f8c0528a32a24803c8
https://pubmed.ncbi.nlm.nih.gov/36454263
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6
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial
Autor: Yvonne Tami, Shihyun You, Melanie Paff, Jeong-Won Jang, Robert Elston, Sung-Jae Park, Phillip J. Yates, Yu Tao, Jung Hwan Yoon, C. Frank Bennett, Jennifer Cremer, Jeong Heo, Dickens Theodore, T. Jesse Kwoh, Man-Fung Yuen, Young-Oh Kweon, Fiona Campbell
Publikováno v: Nature Medicine
Cell Reports Medicine
Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from cirrhosis and hepatocellular carcinoma. Functional cure rates are low with current treatment options (nucleos(t)ide analogs (NAs) and pegylated interferons). Bepi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee63e356dfb8c2df2abc6ba2ec04af2
http://europepmc.org/articles/PMC8516644
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7
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells
Autor: Sebastien A. Burel, Todd Machemer, Brenda F. Baker, T. Jesse Kwoh, Suzanne Paz, Husam Younis, Scott P. Henry
Publikováno v: Nucleic acid therapeutics. 32(6)
A human peripheral blood mononuclear cell (PBMC)-based assay was developed to identify antisense oligonucleotide (ASO) with the potential to activate a cellular innate immune response outside of an acceptable level. The development of this assay was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7850a496fa46739046720e393abb6b4
https://pubmed.ncbi.nlm.nih.gov/35976085
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8
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia
Autor: Eugene Schneider, Li-Jung Tai, Sebastien A. Burel, Padmakumar Narayanan, Joseph A. Tami, Lijiang Shen, Joseph L. Witztum, T. Jesse Kwoh, Scott P. Henry, Suzanne Paz, Brett P. Monia, Steven G. Hughes, Jeffery A Engelhardt, Sanford J. Shattil, Shuting Xia, Todd Machemer, Brian R. Curtis
Publikováno v: Nucleic Acid Therapeutics. 30:94-103
Inotersen, a 2'-O-methoxyethyl (2'-MOE) phosphorothioate antisense oligonucleotide, reduced disease progression and improved quality of life in patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in the NEURO-TTR and NEU
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3ffffb1daa283b051e7ec72a1e47a2
https://doi.org/10.1089/nat.2019.0829
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