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Akademický článek

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

Autor: P. Savola, T. Kelkka, H. L. Rajala, A. Kuuliala, K. Kuuliala, S. Eldfors, P. Ellonen, S. Lagström, M. Lepistö, T. Hannunen, E. I. Andersson, R. K. Khajuria, T. Jaatinen, R. Koivuniemi, H. Repo, J. Saarela, K. Porkka, M. Leirisalo-Repo, S. Mustjoki

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of c

Externí odkaz: https://doaj.org/article/b34d9e4915724e738eb008462bd3f4e7

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The influence of carbon based coatings and surface finish on the tribological performance in high-load contacts

Autor: Jari Koskinen, Simo Varjus, Oskari Elomaa, T. Jaatinen, Lauri Kilpi, Helena Ronkainen

Publikováno v: Ronkainen, H, Elomaa, O, Varjus, S, Kilpi, L, Jaatinen, T & Koskinen, J 2016, ' The influence of carbon based coatings and surface finish on the tribological performance in high-load contacts ', Tribology International, vol. 96, pp. 402-409 . https://doi.org/10.1016/j.triboint.2015.04.019

The effect of surface finish with two types of carbon based coatings was evaluated in rolling contact twin disc tests. The surface finish grades represented the ground surface, and two polished surfaces providing average surface roughness values of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662e4331965179879b1253c5552e08e3
https://doi.org/10.1016/j.triboint.2015.04.019

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Akademický článek

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Biochemical and structural characterisation of membrane-containing icosahedral dsDNA bacteriophages infecting thermophilic Thermus thermophilus

Autor: Sarah J. Butcher, Pasi Laurinmäki, Lotta Happonen, Dennis H. Bamford, Silja T. Jaatinen

Publikováno v: Virology. 379:10-19

Icosahedral dsDNA viruses isolated from hot springs and proposed to belong to the Tectiviridae family infect the Gram-negative thermophilic Thermus thermophilus bacterium. Seven such viruses were obtained from the Promega Corporation collection. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19cb84a9a4c495c537ee56c63921c7d
https://doi.org/10.1016/j.virol.2008.06.023

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Conflicting HLA assignment by three different typing methods due to the apparent loss of heterozygosity in the MHC region

Autor: T, Linjama, U, Impola, R, Niittyvuopio, O, Kuittinen, A, Kaare, J, Rimpiläinen, L, Volin, J, Peräsaari, T, Jaatinen, J, Lauronen, T, Saarinen, E, Juvonen, J, Partanen, S, Koskela

Publikováno v: HLA. 87(5)

Loss of heterozygosity (LOH) has been reported to cause false human leukocyte antigen (HLA) homozygous typing results in pre-transplant patients suffering from haematological malignancies, who in fact are HLA heterozygous. This poses a challenge for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff868e4160e535c22ddb6d3066d00cf6
https://pubmed.ncbi.nlm.nih.gov/26969202

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Akademický článek

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Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation

Autor: J, Sivula, Z M, Cordova, J, Tuimala, T, Jaatinen, J, Partanen, L, Volin, H, Turpeinen

Publikováno v: Scandinavian journal of immunology. 76(3)

Graft-versus-host disease (GvHD) is a major complication in hematopoietic stem cell transplantation (HSCT). The immune response against gut microbes is thought to be an important factor in the beginning of GvHD. Toll-like receptors (TLR) recognize mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b610963cb7a5ca581e638c0698fa143
https://pubmed.ncbi.nlm.nih.gov/22703024

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HLA antigen, allele and haplotype frequencies and their use in virtual panel reactive antigen calculations in the Finnish population

Autor: K, Haimila, J, Peräsaari, T, Linjama, S, Koskela, T, Saarinenl, J, Lauronen, M-K, Auvinen, T, Jaatinen

Publikováno v: Tissue antigens. 81(1)

The human leukocyte antigen (HLA) antigen, allele and haplotype frequencies of the Finnish population are quite unique because of a rather restricted and homogeneous gene pool. This has a strong influence on finding suitable donors for transplant pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edc2e3993ecdf202cb93fc1902a04525
https://pubmed.ncbi.nlm.nih.gov/23216287

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The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea

Autor: Jaana K. H. Bamford, Simonas Laurinavičius, Dennis H. Bamford, Elina Ahola-Iivarinen, Silja T. Jaatinen, Matti Jalasvuori, Nisse Kalkkinen

Publikováno v: Journal of virology. 83(18)

We have sequenced the genome and identified the structural proteins and lipids of the novel membranecontaining, icosahedral virus P23-77 of Thermus thermophilus. P23-77 has an 17-kb circular double-stranded DNA genome, which was annotated to contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9e8952c0522de7c585a0664f1a8104
https://pubmed.ncbi.nlm.nih.gov/19587059

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