Zobrazeno 1 - 10
of 64
pro vyhledávání: '"T. J. Wiktor"'
Publikováno v:
Nigerian Veterinary Journal; Vol 27, No 2 (2006); 41-53
The authors studied 12 street rabies virus isolates from 3 states of Nigeria using both the anti-nucleocapsid and anti-glycoprotein monoclonal antibodies and cross-protection tests. It was observed that all the viruses were rabies having divergent an
Autor:
H Koprowski, T J Wiktor
Publikováno v:
Proceedings of the National Academy of Sciences. 75:3938-3942
Somatic cell hybrids (hybridomas) between mouse myeloma cells and spleen cells derived from BALB/c mice immunized with inactivated rabies vaccine were found to produce antibodies to rabies virus. Monoclonal antibodies with different specificities wer
Publikováno v:
The Journal of Immunology. 136:692-697
By using a preparation of inactivated rabies virus, the blood mononuclear cells from five rabies vaccine recipients were stimulated in vitro in the presence of interleukin 2. T cell lines that displayed significant proliferative responses to whole ra
Publikováno v:
The Journal of Immunology. 114:1761-1765
The HEP and ts2 strains of rabies virus inoculated intracerebrally into adult mice normally cause clinically inapparent infection. In the experiments described, this is converted into a lethal infection by immunosuppression with cyclophosphamide, whi
Autor:
R I Macfarlan, B Dietzschold, T J Wiktor, M Kiel, R Houghten, R A Lerner, J G Sutcliffe, H Koprowski
Publikováno v:
The Journal of Immunology. 133:2748-2752
The antigenic structure of the rabies virus glycoprotein has been studied. A limited number of fragments were obtained by cyanogen bromide (CNBr) cleavage of viral glycoprotein, and eight large peptides were isolated by using sodium dodecyl sulfate (
Publikováno v:
The Journal of Experimental Medicine
Mice lethally infected with street rabies virus failed to develop cytotoxic T cells specific for rabies virus-infected target cells, whereas high levels of cell-mediated cytotoxicity (CMC) were generated after nonfatal infection with the attenuated h
Publikováno v:
Journal of Virological Methods. 1:33-46
A panel of selected monoclonal antibodies directed against the nucleocapsid antigens of rabies and rabies-related viruses allowed the rapid identification both of antigens of rabies virus origin present in impression smears of brains from infected an
Publikováno v:
The Journal of Immunology. 93:353-366
Summary In spite of the initial infectivity of three strains of rabies virus for the human diploid cell strain WI-38, the virus could not be serially propagated in this cell system with conventional methods of passaging infectious material. However,
Publikováno v:
The Journal of Immunology. 110:269-276
The envelope glycoprotein of rabies virus was shown to be the antigen responsible for the induction of virus neutralizing (VN) antibody formation and for the protection of animals against subsequent challenge with rabies virus. Preparation of two oth