Zobrazeno 1 - 10
of 68
pro vyhledávání: '"T. J. Torphy"'
Autor:
Yassine Amrani, T J Torphy, Rebecca Hoffman, Aili L. Lazaar, Reynold A. Panettieri, Raymond B. Penn, Douglas W. P. Hay, Alaina J. Ammit
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 23:794-802
Although 3':5' cyclic adenosine monophosphate (cAMP) is known to modulate cytokine production in a number of cell types, little information exists regarding cAMP-mediated effects on this synthetic function of human airway smooth-muscle (HASM) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4b222e37e7a94142810d2976a6dd75
https://doi.org/10.1165/ajrcmb.23.6.4184
https://doi.org/10.1165/ajrcmb.23.6.4184
Autor:
Rush Ja, Esser Km, L. B. Cieslinski, M S Barnette, T J Torphy, Burman M, Siegfried B. Christensen, Prabhakar Us, Bartus Jo
Publikováno v:
Biochemical Pharmacology. 51:949-956
Phosphodiesterase 4 (PDE4) inhibitors are novel anti-inflammatory compounds. Unfortunately, the archetypal PDE4 inhibitor rolipram produces central nervous system and gastrointestinal side-effects. To exploit these agents, we need to identify PDE4 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd37212797c4643cdca190be92a344
https://doi.org/10.1016/0006-2952(96)00053-6
https://doi.org/10.1016/0006-2952(96)00053-6
Autor:
Henry M. Sarau, Han-Liang Zhou, Mary S. Barnette, Carol D. Manning, James J. Foley, T J Torphy
Publikováno v:
Journal of Biological Chemistry. 270:23598-23604
Previous studies with U937 cells, a human monocyte cell line, have shown that the activity of cyclic nucleotide phosphodiesterase 4 (PDE4) is increased by agents that elevate cyclic AMP content. The present experiments were conducted to determine 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4b13dc6563091eaeb1ede493f549c5
https://doi.org/10.1074/jbc.270.40.23598
https://doi.org/10.1074/jbc.270.40.23598
Publikováno v:
Microbiology. 140:1533-1542
We have cloned a Candida albicans gene, which encodes a cyclic nucleotide phosphodiesterase (PDEase), by complementation in a Saccharomyces cerevisiae PDEase-deficient mutant. The deduced amino acid sequence is similar to that of the low-affinity PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1bc6a4426db2ce024961ab0b481c4
https://doi.org/10.1099/13500872-140-7-1533
https://doi.org/10.1099/13500872-140-7-1533
Publikováno v:
The Journal of Immunology. 151:339-350
Increasing cellular levels of cAMP inhibit eicosanoid production in the human neutrophil; however, little is known about the effects of cAMP on platelet-activating factor (PAF) biosynthesis in this cell. In the current study, the beta-adrenergic rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87625adb1ac4a77db77962378a30308d
https://doi.org/10.4049/jimmunol.151.1.339
https://doi.org/10.4049/jimmunol.151.1.339
Autor:
James J. Foley, Han-Liang Zhou, Marie Chabot-Fletcher, M. N. Tzimas, James D. Winkler, Henry M. Sarau, T. J. Torphy
Publikováno v:
Biochemical Pharmacology. 46:139-148
We have explored the role of phospholipase D (PLD) activation in leukotriene B4 (LTB4)-induced Ca2+ mobilization and degranulation of human neutrophils. Stimulation of [3H]alkyl-acyl-phosphatidylcholine-labeled neutrophils with LTB4 resulted in a rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb2b2f8d8956ea9dad82657f616129f
https://doi.org/10.1016/0006-2952(93)90358-4
https://doi.org/10.1016/0006-2952(93)90358-4
Publikováno v:
Journal of Biological Chemistry. 268:6470-6476
We have isolated cDNA clones from human frontal cortex cDNA libraries that encode a unique subtype of the low-Km, cAMP-specific phosphodiesterases (PDEs IV). The 564-amino acid sequence of the protein (human brain PDE IV (hPDE IVB)) shows significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1530e105122a0f3d04c116f0d44a5f62
https://doi.org/10.1016/s0021-9258(18)53275-0
https://doi.org/10.1016/s0021-9258(18)53275-0
Publikováno v:
Pulmonary Pharmacology. 5:153-157
The ability of SKF 104353 to prevent and reverse leukotriene (LT) D4- and antigen (Ag)-induced bronchoconstriction was examined in anesthetized, spontaneously breathing cynomolgus monkeys. Aerosol administration of LTD4 (10 micrograms/ml; 20 breaths)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8019acd28e18eea43d93794b6fa5ed
https://doi.org/10.1016/0952-0600(92)90035-f
https://doi.org/10.1016/0952-0600(92)90035-f
Autor:
P T Peachell, B J Undem, R P Schleimer, D W MacGlashan, L M Lichtenstein, L B Cieslinski, T J Torphy
Publikováno v:
The Journal of Immunology. 148:2503-2510
We attempted to identify and establish the role of cyclic nucleotide phosphodiesterase (PDE) isozymes in human basophils by using standard biochemical techniques as well as describing the effects of isozyme-selective and nonselective inhibitors of PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633ba8a89d8d16cfd324e1fff2f41a2e
https://doi.org/10.4049/jimmunol.148.8.2503
https://doi.org/10.4049/jimmunol.148.8.2503
Autor:
L. Vickery-Clark, R.M. Muccitelli, R.D. Eckardt, L.-A.P. Yodis, Henry M. Sarau, M.A. Wasserman, C.M. Saverino, John G. Gleason, T. J. Torphy, R.R. Osborn, J. F. Newton, L.S. Novak, D.W.P. Hay
Publikováno v:
Pulmonary Pharmacology. 4:177-189
In this report the pharmacologic and pharmacokinetic profile of the leukotriene receptor antagonist 3(S)-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid (SKF S-106203) in guinea-pigs is described. In isolated guinea-pig tracheae SKF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b92bc157e3aa17bcaebad9896d76745
https://doi.org/10.1016/0952-0600(91)90009-r
https://doi.org/10.1016/0952-0600(91)90009-r