Výsledky vyhledávání - "T. J. R. Harris"

Promising Targets for the Treatment of Neurodegenerative Diseases

Autor: S L Budd Haeberlein, T J R Harris

Publikováno v: Clinical Pharmacology & Therapeutics. 98:492-501

Genetics and pathology have proven to be an effective combination to identify an evolving and deepening landscape of pathways and potential therapeutic targets in neurodegenerative diseases. Initially this landscape appeared to be populated with dist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bbdbd4dd36a46747d222ac068bf511
https://doi.org/10.1002/cpt.195

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A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

Autor: Chris I. Newbold, Kevin Marsh, Jennifer Ruth Sadler Hall, T. J. R. Harris, Valerie E. Tate, Kathryn J. H. Robson, David J. Weatherall, M. W. Jennings

Publikováno v: Scopus-Elsevier

As a consequence of gene cloning and DNA sequencing several gene families are emerging in the field of cell–cell recognition. These include immunoglobulins, integrins, certain extracellular glycoproteins1 and a family of functionally unrelated prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6749c22f5857f5f4a8018dc030b0df
https://ora.ox.ac.uk/objects/uuid:15bb2b0c-2972-44ba-89c2-f013ea6e4391

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ChemInform Abstract: Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

Autor: M. E. Wall, Dan Brown, Geoffrey A. Cordell, Chris Beecher, R M Tait, T. J. R. Harris, Norman R. Farnsworth, M J O'Neill, Djaja D. Soejarto, J. A. Lewis, A. D. Kinghorn, John M. Pezzuto, Mansukh C. Wani

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4828187e50e28a1f17f0f27e0152210c
https://doi.org/10.1002/chin.199420318

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The impact of biotechnology and molecular biology on the pharmaceutical industry

Autor: A. N. Hobden, T. J. R. Harris

Publikováno v: Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences. 99:37-45

Synopsis:Biotechnology had its initial impact on the pharmaceutical industry well before the perceived time. The use of fermentation technology to produce antibiotics was a cornerstone for the development of the industry. This event was both before c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::982e072dbb89bbc9daa1bf46e5feb9e0
https://doi.org/10.1017/s0269727000013038

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A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort

Autor: Peter Nürnberg, J. Hall, M. F. Curran, H. Sakul, S. J. H. Van Deventer, John E. Lennard-Jones, A Macpherson, Jochen Hampe, A. Buckler, M M Mirza, S. Bridger, Sarah H. Shaw, Pieter C. F. Stokkers, K. F. Lau, Stefan Schreiber, John C.W. Lee, Christopher G. Mathew, Lon R. Cardon, T. J. R. Harris

Publikováno v: American journal of human genetics, 64(3), 808-816. Cell Press

SummaryInflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical and histologic features: Crohn disease and u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa6584ed411348cc9d23cf31b66ec0d
https://pure.amc.nl/en/publications/a-genomewide-analysis-provides-evidence-for-novel-linkages-in-inflammatory-bowel-disease-in-a-large-european-cohort(059ace95-ccf4-404d-be6f-59209054f92a).html

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Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16

Publikováno v: Gastroenterology, 115(5), 1066-1071. W.B. Saunders Ltd

Background & Aims: Inflammatory bowel disease (IBD) is a complex disorder of unknown etiology. Epidemiological investigations suggest a genetic basis for IBD. Recent genetic studies have identified several IBD linkages. The significance of these link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03d7a97e0ff90e4544094bcf49b5615
https://pure.amc.nl/en/publications/genetic-analysis-of-inflammatory-bowel-disease-in-a-large-european-cohort-supports-linkage-to-chromosomes-12-and-16(c7ad123f-2323-4a52-ad33-013969a710ee).html

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High throughput X-ray crystallography for Drug Discovery

Autor: T. J. R. Harris

Publikováno v: Biochemical Society Transactions. 28:A131-A131

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::145ab2616ad8dbc44c13e64ebb669bc1
https://doi.org/10.1042/bst028a131b

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Genetic analysis of inflammatory bowel disease in a large european patient population supports linkage to human chromosomes 12 and 16

Publikováno v: Gastroenterology. 114:A957

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77a2dbe05201d9ac9fb07f7cb3ea6b40
https://doi.org/10.1016/s0016-5085(98)83899-7

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Sequence data

Autor: T. J. R. HARRIS

Publikováno v: Nature. 355:581-581

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad90f97692ad867b4da1e9c3249d7c9c
https://doi.org/10.1038/355581c0

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An Assessment by Competition Hybridization of the Sequence Homology between the RNAs of the Seven Serotypes of FMDV

Autor: T. J. R. Harris, Kathryn J. H. Robson, F. Brown

Publikováno v: Journal of General Virology. 37:271-276

Summary A comparison has been made of the RNAs of the seven serotypes of foot-and-mouth disease virus (FMDV) by competition hybridization. Homology among the three European serotypes A, O, C and the Asia 1 serotype was 60 to 70%. Similar homologies w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c9c2e328011c853da88dbf859df48b
https://doi.org/10.1099/0022-1317-37-2-271

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