Zobrazeno 1 - 10
of 51
pro vyhledávání: '"T. J. M. Smeets"'
Autor:
Ferdinand C. Breedveld, Peter C. Taylor, A. E. Meinders, T. J. M. Smeets, Paul P. Tak, Philip M. Kluin, Mohamed R. Daha, Ravinder Nath Maini
OBJECTIVE: The effect of chimeric anti-tumor necrosis factor alpha (TNF alpha) monoclonal antibody (MAb) therapy on synovial inflammation was studied in order to address the hypothesis that anti-TNF alpha therapy leads to down-regulation of adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4749d2740ba6de3d7438fe5d47119540
https://ora.ox.ac.uk/objects/uuid:655bc469-01a2-47fc-abff-d2202d3b3011
https://ora.ox.ac.uk/objects/uuid:655bc469-01a2-47fc-abff-d2202d3b3011
Publikováno v:
Annals of the rheumatic diseases, 65(12), 1551-1557. BMJ Publishing Group
Background: The synovial tissue is a primary target of many inflammatory arthropathies, including psoriatic arthritis (PsA). Identification of proinflammatory molecules in the synovium may help to identify potentially therapeutic targets. Objective:
Autor:
Paul P. Tak, J G I van Rietschoten, Maarten C. Kraan, P. V. Kasperkovitz, T.C.T.M. (Tineke) van der Pouw Kraan, Cornelis L. Verweij, N L Verbeet, T. J. M. Smeets
Publikováno v:
Annals of the Rheumatic Diseases, 63(3), 233-9. BMJ Publishing Group
Annals of the Rheumatic Diseases, 63(3), 233-239. BMJ Publishing Group
Kasperkovitz, P V, Verbeet, N L, Smeets, TJ, van Rietschoten, J G I, Kraan, MC, van der Pouw Kraan, TC, Tak, PP & Verweij, C L 2004, ' Activation of the STAT1 pathway in rheumatoid arthritis. ', Annals of the Rheumatic Diseases, vol. 63, no. 3, pp. 233-9 . https://doi.org/10.1136/ard.2003.013276
Annals of the rheumatic diseases, 63(3), 233-239. BMJ Publishing Group
Annals of the Rheumatic Diseases, 63(3), 233-239. BMJ Publishing Group
Kasperkovitz, P V, Verbeet, N L, Smeets, TJ, van Rietschoten, J G I, Kraan, MC, van der Pouw Kraan, TC, Tak, PP & Verweij, C L 2004, ' Activation of the STAT1 pathway in rheumatoid arthritis. ', Annals of the Rheumatic Diseases, vol. 63, no. 3, pp. 233-9 . https://doi.org/10.1136/ard.2003.013276
Annals of the rheumatic diseases, 63(3), 233-239. BMJ Publishing Group
Background: Expression of signal transducer and activator of transcription 1 (STAT1), the mediator of interferon (IFN) signalling, is raised in synovial tissue (ST) from patients with rheumatoid arthritis ( RA). Objectives: To determine the extent to
Publikováno v:
Annals of the Rheumatic Diseases, 62, 635-638. BMJ Publishing Group
Annals of the rheumatic diseases, 62(7), 635-638. BMJ Publishing Group
Annals of the rheumatic diseases, 62(7), 635-638. BMJ Publishing Group
Background: Synovial tissue (ST) from end stage destructive rheumatoid arthritis (RA) and arthroscopic biopsies obtained during active inflammation might exhibit different characteristics. Objective: To define the cell infiltrate and the expression o
Publikováno v:
Annals of the Rheumatic Diseases, 62(8), 715-721. BMJ Publishing Group
Annals of the rheumatic diseases, 62(8), 715-721. BMJ Publishing Group
Annals of the rheumatic diseases, 62(8), 715-721. BMJ Publishing Group
Background: Chemokines and their receptors are considered important contributors in cell migration and inflammation in chronic inflammatory disorders. Chemokines affecting monocytes/macrophages are considered potential therapeutic targets, but no stu
Publikováno v:
Annals of the rheumatic diseases, 60(6), 561-565. BMJ Publishing Group
Annals of the Rheumatic Diseases, 60(6), 561-565. BMJ Publishing Group
Annals of the Rheumatic Diseases, 60(6), 561-565. BMJ Publishing Group
OBJECTIVES—Examination of synovial tissue (ST) obtained at surgery because of end stage destructive rheumatoid arthritis (RA) showed that macrophages and fibroblasts are the major cell types at the cartilage-pannus junction (CPJ). This study aimed
Autor:
T. van Gelder, C. J. Knoop, W. Weimar, Lex P.W.M. Maat, Hubert G. M. Niesters, Carla C. Baan, T. J. M. Smeets, Cecile T.J. Holweg, F. van der Ham, A. H. M. M. Balk, Pieter E. Zondervan
Publikováno v:
Transplantation. 67:870-876
BACKGROUND Despite blockade of the interleukin-2/interleukin 2 receptor (IL-2/IL-2R) pathway by the murine anti-CD25 (i.e., IL-2R alpha chain) monoclonal antibody BT563, cardiac rejection can still occur. In these cases, growth factors other than IL-
Autor:
Barry Bresnihan, PP Tak, T. J. M. Smeets, Oliver FitzGerald, P. P. Youssef, Gaye Cunnane, F. C. Breedveld
Publikováno v:
Rheumatology. 37:1003-1007
Microscopic measurement of inflammation in synovial tissue may be important in studies of clinical status, prognosis and response to treatment. The aim of this study was to compare quantitative microscopic analysis of inflammation with a semiquantita
Autor:
Ferdinand C. Breedveld, Paul P. Tak, A. Edo Meinders, Mohamed R. Daha, T. J. M. Smeets, Philip M. Kluin, Erik W. Thurkow, Ineke M. van der Heijden
Publikováno v:
The Journal of Pathology. 181:444-450
Recently, a new player in the cytokine network has been described that is produced by monocytes and can be detected in the rheumatoid synovium: interleukin-15 (IL-15). Since this cytokine may play a role in the accumulation and activation of T-cells,
Autor:
Paul P. Tak, Mohamed R. Daha, Ferdinand C. Breedveld, K. A. E. Meijers, Ronald Brand, T. J. M. Smeets, Philippus Kluin, A. E. Meinders
Publikováno v:
Arthritis & Rheumatism. 40:217-225
Objective. To define variations in the cellular infiltrate and in the expression of monokines in synovial tissue (ST) from rheumatoid arthritis (RA) patients with different durations of disease and different levels of disease activity. Methods. The i