Výsledky vyhledávání

Effects of U-75875, a peptidomimetic inhibitor of retroviral proteases, on simian immunodeficiency virus infection in rhesus monkeys

Autor: S Thaisrivongs, T J Vidmar, M J Ruwart, E D Roberts, Louis N. Martin, T J Kakuk, S R Davio, Kenneth F. Soike, Michael Murphey-Corb, Rudolf P. Bohm

U-75875 inhibits human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus (SIV) proteases and blocks Gag-Pol protein processing and viral maturation and replication in vitro. Rhesus monkeys were treated with vehicle alone or with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74149d7c9ef41251a9f0f60b0d11cf8c
https://europepmc.org/articles/PMC188198/

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Precipitation of the renin inhibitor ditekiren upon i.v. infusion; in vitro studies and their relationship to in vivo precipitation in the cynomolgus monkey

Autor: S R, Davio, M M, McShane, T J, Kakuk, R M, Zaya, S L, Cole

Publikováno v: Pharmaceutical research. 8(1)

Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug involved continuous i.v. infusions through indwelling catheters in the right internal jugular vein of the cynomolgus monk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4bce824dce40b3f011ae24670781559
https://pubmed.ncbi.nlm.nih.gov/2014212

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Avian lymphoid leukosis prophylaxis with mibolerone

Autor: T J, Kakuk, F R, Frank, T E, Weddon

Publikováno v: Avian diseases. 21(2)

Duplicate trials with mibolerone at a dose of 1 microng/g of diet for the first 49 days of age reduced the incidence of lymphoid leukosis (LL) significantly (P less than .005) in chickens inoculated as day-old chicks with Rous-associated virus type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ecacfdcce397014088a6d5ed156f74d
https://pubmed.ncbi.nlm.nih.gov/869826

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Clinical evaluation of amitraz for treatment of canine scabies

Autor: S D, Folz, T J, Kakuk, C L, Henke, D L, Rector, F B, Tesar

Publikováno v: Modern veterinary practice. 65(8)

A liquid concentrate formulation of amitraz (Mitaban: Upjohn) was used to topically treat 181 dogs with scabies, at an active drug level of 250 ppm, or 10.6 ml of concentrate in 2 gal water. After the dogs were clipped and bathed, the diluted medicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ab2c49dd4e904331e885f96ce6582db
https://pubmed.ncbi.nlm.nih.gov/6387437

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Immune responses of chickens fed the androgen analog mibolerone

Autor: C H, Romero, H G, Purchase, F, Frank, B R, Burmester, T J, Kakuk, T S, Chang

Publikováno v: Avian diseases. 21(2)

Mibolerone, an androgen analog (17 beta-hydroxy-7-alpha, 17-dimethylestr-4-en-3-one), induces a slow but progressive involution of the bursa of Fabricius when fed to chickens at microng levels during the first 7 weeks of life. Chickens receiving mibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d23597970c11aab0dd26120f2ceff63
https://pubmed.ncbi.nlm.nih.gov/405963

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