Zobrazeno 1 - 10
of 23
pro vyhledávání: '"T. J. Hallam"'
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:137-141
Female sexual dysfunction (FSD) is a term that encompasses a collection of sexual disorders that can affect women throughout their adult life. FSD has multiple causes, with physiological,psychological, and social determinants.1 The complexity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f355632981f0e30e6d2f946e2103daee
https://doi.org/10.1038/clpt.2010.262
https://doi.org/10.1038/clpt.2010.262
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(8)
We have used in vitro models of thymocyte positive and negative selection in conjunction with selective inhibitors of the TCR-mediated signaling cascade to investigate the intracellular signaling events that mediate these processes. We report that Ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6b4ccf1b5c3be78f237ba478f2e0f96
https://pubmed.ncbi.nlm.nih.gov/7706707
https://pubmed.ncbi.nlm.nih.gov/7706707
Publikováno v:
The Biochemical journal. 303
Stimulation of Jurkat E6 cells with anti-CD3 antibody results in a characteristic rise in [Ca2+]i which is due to both the release of Ca2+ from intracellular stores and the entry of external Ca2+. Individual components of the [Ca2+]i increase were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15900c790b7370211f83f095755eb317
https://pubmed.ncbi.nlm.nih.gov/7980431
https://pubmed.ncbi.nlm.nih.gov/7980431
Autor:
A M, Birchall, J, Bishop, D, Bradshaw, A, Cline, J, Coffey, L H, Elliott, V M, Gibson, A, Greenham, T J, Hallam, W, Harris
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(2)
Several lines of circumstantial evidence support the assumption that protein kinase C (PKC) activation together with elevated levels of cytosolic Ca++ are necessary for T-cell activation and proliferation in response to a physiological stimulus, i.e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ee2a26311fc7e321bd339c243d52461
https://pubmed.ncbi.nlm.nih.gov/8114006
https://pubmed.ncbi.nlm.nih.gov/8114006
Publikováno v:
Oncology research. 6(9)
We have investigated the relationship between protein kinase C (PKC), levels of resistance and drug used for selection in a series of human KB carcinoma cell lines by comparing protein kinase C activity and PKC alpha, beta I, beta II, gamma, delta, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22f536c1db086ae6a07049032338f7f1
https://pubmed.ncbi.nlm.nih.gov/7703529
https://pubmed.ncbi.nlm.nih.gov/7703529
Autor:
T J, Hallam
Publikováno v:
Clinical and experimental rheumatology. 11
The assumption that protein kinase C activation is necessary for T-cell activation in response to MHC class II restricted antigen-presentation is supported by several lines of circumstantial evidence. We have developed potent, cell-permeable and sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f72d9a45082ed15eb675766b8d32193
https://pubmed.ncbi.nlm.nih.gov/8324939
https://pubmed.ncbi.nlm.nih.gov/8324939
Publikováno v:
Europe PubMed Central
Stimulated adherence of human neutrophils to plastic and changes in cytosolic free Ca2+ concn. [(Ca2+]i) were measured in the same cell preparations. [Ca2+]i-activation curves were constructed to compare the relation between [Ca2+]i and adhesion in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b527a760523726eca1f76732f31095a1
https://pubmed.ncbi.nlm.nih.gov/2109601
https://pubmed.ncbi.nlm.nih.gov/2109601
Autor:
T J Rink, T J Hallam
Publikováno v:
The Journal of Physiology. 368:131-146
ADP produces a rapid elevation in the concentration of cytoplasmic free calcium, [Ca2+]i, in quin2-loaded human platelets which begins within 1 s of stimulation and peaks after 10 s. In the presence of 1 mM-extracellular calcium, [Ca2+]i peaks at 670
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af79463e833d84d00b3ad11f83f1401
https://doi.org/10.1113/jphysiol.1985.sp015850
https://doi.org/10.1113/jphysiol.1985.sp015850
Publikováno v:
Thrombosis and Haemostasis. 47:278-284
Summary1. Exposure of human and rabbit blood platelets to all full agonists tested induces agonist-specific (or homologous) desensitisation except in the case of adrenaline and collagen in human platelets.2. Desensitisation to vasopressin and 5-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef129f8221d5ff49ab50f19a19bd3e36
https://doi.org/10.1055/s-0038-1657185
https://doi.org/10.1055/s-0038-1657185
Autor:
J E Merritt, T J Hallam
Publikováno v:
Journal of Biological Chemistry. 263:6161-6164
Stimulation of platelets with thrombin or parotid acinar cells with carbachol results in an increase in [Ca2+]i which is due to both release from internal stores and influx across the plasma membrane. In platelets, thrombin also stimulates Mn2+ entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd65f27a644d442f364501b1d975237
https://doi.org/10.1016/s0021-9258(18)68765-4
https://doi.org/10.1016/s0021-9258(18)68765-4