Zobrazeno 1 - 10
of 19
pro vyhledávání: '"T. J. Ferro"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L1127-L1134
Vimentin is one of the mammalian intermediate filament proteins. It is expressed in cells of mesenchymal origin and is characteristic of proliferating cells at the fetal stage. During malignancy, vimentin expression is activated in certain lung epith
Autor:
T. J. Ferro, Shijian Chu
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L983-L992
Oxidative stress often results in changes in gene expression through the regulation of transcription factors. In this study, we examine how Sp1 phosphorylation is regulated by H2O2 in a human alveolar epithelial cell line (HAE). Treatment of HAE cell
Autor:
Shijian Chu, T. J. Ferro
Publikováno v:
Gene. 348:1-11
As the prototype of a family of transcription factors, Sp1 has been extensively studied and widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was reported more than a decade ago. Since then, an increasing numb
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L1107-L1117
We tested the hypothesis that protein kinase C-alpha (PKC-alpha) mediates tumor necrosis factor-alpha (TNF-alpha)-induced alterations in permeability of pulmonary microvessel endothelial monolayers (PEM). The permeability of PEM was assessed by the c
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 267:L282-L290
We postulated that tumor necrosis factor-alpha (TNF) "primes" the lung for the development of pulmonary vasoconstriction and edema by activating protein kinase C (PKC). Guinea pigs were injected with TNF (1.6 x 10(5) U/kg i.p.), and the lungs were is
Autor:
T. J. Ferro, Arnold Johnson
Publikováno v:
Journal of Applied Physiology. 73:2483-2492
We tested the hypothesis that tumor necrosis factor-alpha (TNF-alpha) increases pulmonary vasoconstriction by decreases in nitric oxide- (NO) dependent vasodilation. Lungs were isolated from guinea pigs 18 h after intraperitoneal injection of either
Publikováno v:
Journal of Applied Physiology. 72:179-185
We tested the hypothesis that dextran sulfate and heparin sulfate inhibit platelet-activating factor- (PAF) induced pulmonary edema in the isolated perfused guinea pig lung via a charge-dependent mechanism. Dextran sulfate prevented the changes in pu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 261:H996-H1004
We tested the hypothesis that tumor necrosis factor-alpha (TNF-alpha) primes the hemodynamic response to the neutrophil agonist N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) in lungs isolated from guinea pigs. Lungs were isolated from animals
Publikováno v:
Journal of Applied Physiology. 70:1121-1128
We tested the hypothesis that neutrophil sequestration is required for the development of tumor necrosis factor- (TNF) induced neutrophil- (PMN) dependent pulmonary edema. TNF (3.2 X 10(5) U/kg ip) was injected into guinea pigs 18 h before lung isola
Publikováno v:
The European respiratory journal. 30(4)
Cigarette smoke has been associated with lung fluid accumulation and increased risk of acute respiratory distress syndrome. It was postulated that ENaC alpha-subunit, which plays a critical role in lung fluid absorption, is affected by cigarette smok