Zobrazeno 1 - 10
of 14
pro vyhledávání: '"T. J. B. Simons"'
Publikováno v:
Clinical Science. 81:823-829
1. The binding of lead to human blood serum, and components of serum, was studied by titration with the addition of Pb(NO3)2 solution, monitoring the free Pb2+ concentration with a Pb2+ electrode, and by equilibrium dialysis. 2. In fresh serum, about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20675295f13f3cdb8d6a16a0d90a1a27
https://doi.org/10.1042/cs0810823
https://doi.org/10.1042/cs0810823
Autor:
V. Kalfakakou, T. J. B. Simons
Publikováno v:
The Journal of Physiology. 421:485-497
1. Zinc is taken up into human red cells by two mechanisms that depend upon the presence of anions. One of these requires bicarbonate ions, is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) and appears to be catalysed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75da7c03b08bdde53d2ca1f8878f44d3
https://doi.org/10.1113/jphysiol.1990.sp017957
https://doi.org/10.1113/jphysiol.1990.sp017957
Autor:
T. J. B. Simons
Publikováno v:
The Journal of membrane biology. 123(1)
Zinc efflux from human red blood cells is largely brought about by a saturable mechanism that depends upon extracellular Ca2+ ions. It has a Vmax of about 35 mumol/10(13) cells hr, a Km for external Ca2+ of 1 x 10(-4) M, and a Km for internal Zn2+ of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ba62af463c8d90cc86bc031395b51a
https://pubmed.ncbi.nlm.nih.gov/1774776
https://pubmed.ncbi.nlm.nih.gov/1774776
Autor:
T. J. B. Simons
Publikováno v:
The Journal of membrane biology. 123(1)
Zn2+ has been allowed to equilibrate across the red cell membrane using two agents that increase membrane permeability to this ion: the ionophore A23187 and the specific carrier ethylmaltol. Extracellular free Zn2+ was controlled with EGTA (1,2-di(2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54fc1377415b35fa34dc839c276902c
https://pubmed.ncbi.nlm.nih.gov/1774775
https://pubmed.ncbi.nlm.nih.gov/1774775
Autor:
T. J. B. Simons
Publikováno v:
Calcium Transport and Intracellular Calcium Homeostasis ISBN: 9783642839795
The blood of normal human subjects contains 10 – 20 μg Pb/ 100 ml (equivalent to 0.5 – 1 μmol/l.). The blood levels are higher in Pb poisoning. Haematological and neurological symptoms appear when blood Pb is in the range 5 – 10 μmol/l. (Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cfdbe59b146233e5a40656bfdcc6478
https://doi.org/10.1007/978-3-642-83977-1_41
https://doi.org/10.1007/978-3-642-83977-1_41
Autor:
T. J. B. Simons
Publikováno v:
The Journal of Physiology. 405:105-113
1. Resealed human red cell ghosts containing lead buffers bring about a net transfer of lead from the cell interior to the outside. This transfer is ATP dependent. 2. The active transport of lead is characterized by a Vmax (maximum velocity) of 11 mm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b9f07e0ca8bedeafdf4bf31ae046b1
https://doi.org/10.1113/jphysiol.1988.sp017323
https://doi.org/10.1113/jphysiol.1988.sp017323
Autor:
T. J. B. Simons
Publikováno v:
The Journal of Membrane Biology. 66:235-247
Murphy, Coll, Rich and Williamson (J. Biol. Chem. 255:6600--6608, 1980) described a null-point method for estimating intracellular free Ca in liver cells. They used digitonin to lyse the cells in solutions of varying Ca concentration. This method has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11923b6a6e0bcfae825ce2c7499f001
https://doi.org/10.1007/bf01868498
https://doi.org/10.1007/bf01868498
Autor:
T J B Simons
Publikováno v:
British Medical Bulletin. 42:431-434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6d2370bee3593e187ed4c3ba1539a2
https://doi.org/10.1093/oxfordjournals.bmb.a072162
https://doi.org/10.1093/oxfordjournals.bmb.a072162
Autor:
T. J. B. Simons
Publikováno v:
The Journal of Membrane Biology. 84:61-71
Intracellular Pb2+ ions can replace Ca2+ ions in stimulating the Ca-dependent K permeability of human red blood cells. In metabolically depleted resealed ghosts, the threshold for stimulation of 86Rb efflux by internal Pb2+ is around 5 X 10(-10) M, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff1e97ee47e3b1992ec0b5ecb1fb169
https://doi.org/10.1007/bf01871648
https://doi.org/10.1007/bf01871648
Autor:
T. J. B. Simons
Publikováno v:
Nature. 264:467-469
CARBOCYANINE dyes are fluorescent probes of membrane potential in red cells1,2, and their application has been extended to Ehrlich ascites cells3,4 and phytoplankton5. I have used them to study the effect of potassium concentration gradients on the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b28ef6883f45b244c5be6fbb0ebf311
https://doi.org/10.1038/264467a0
https://doi.org/10.1038/264467a0