Zobrazeno 1 - 10
of 53
pro vyhledávání: '"T. Imbert"'
Publikováno v:
ChemInform. 31
The key step of the synthesis of efaroxan was the dihydrobenzofuran ring formation involving an intramolecular cyclization of the tertiary alcohol intermediate with the fluoroaromatic moiety in basic medium. This carbinol was prepared according to tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6ac1cdf31905842144eee36ffeb9dc
https://doi.org/10.1002/chin.200007099
https://doi.org/10.1002/chin.200007099
Autor:
J.-M. Barret, C. Bailly, Jean Philippe Annereau, Y. Guminski, Stéphane Vispé, Nicolas Guilbaud, M. Broussas, V. Brel, Charles Dumontet, S. Bréand, T. Imbert
Publikováno v:
Leukemia research. 34(10)
The polyamine transport system (PTS), hyperactive in cancer cells, can constitute a gate to deliver F14512, a novel spermine epipodophyllotoxin conjugate recently selected for clinical development in AML phase I. We investigated in vitro the high ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92ebcf54b50fd26e321b5d3916d301a
https://pubmed.ncbi.nlm.nih.gov/20096930
https://pubmed.ncbi.nlm.nih.gov/20096930
Publikováno v:
IDrugs : the investigational drugs journal. 4(6)
A review of the literature relating to the therapeutic potential of alpha2-adrenoceptor antagonists published between 1990 and 2000 is presented. Although extensively studied since the early 1970s in a wide spectrum of therapeutic applications, the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0ff27bd74e21732ef821ad351dd95fd
https://pubmed.ncbi.nlm.nih.gov/16001311
https://pubmed.ncbi.nlm.nih.gov/16001311
Publikováno v:
British Journal of Cancer
F 11782 is a novel inhibitor of topoisomerases I and II, with an original mechanism of action (Perrin et al, 2000). This study, aimed to define its anticancer efficacy against a series of murine and human tumour models, has provided evidence of major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06314269a7c9c329d7da40860f2d2988
https://pubmed.ncbi.nlm.nih.gov/11076662
https://pubmed.ncbi.nlm.nih.gov/11076662
Publikováno v:
Anti-cancer drug design. 13(4)
Podophyllotoxin and epipodophyllotoxin react with tubulin at the same binding site as colchicine, but in contrast to colchicine, do not appear to exert their cytotoxicities by mechanisms dependent on P-glycoprotein (Pgp) expression. To investigate st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88204e5be882a84bbac597f26732dce6
https://pubmed.ncbi.nlm.nih.gov/9627671
https://pubmed.ncbi.nlm.nih.gov/9627671
Publikováno v:
Annales Françaises d'Anesthésie et de Réanimation. 32:A423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a644e4c290b31182038331bd4aa4c5
https://doi.org/10.1016/j.annfar.2013.07.786
https://doi.org/10.1016/j.annfar.2013.07.786
Autor:
C. Bailly, T. Imbert, Nicolas Guilbaud, Jean Philippe Annereau, V. Brel, Jean-Marc Barret, Charles Dumontet, Y. Guminski, F. Breillout
Publikováno v:
Journal of Clinical Oncology. 27:11087-11087
11087 Background: The Polyamine Transport System (PTS) is an energy-dependent machinery generally hyper-active in cancer cells with a high demand for polyamines. This system can be viewed as a suitable molecular gate to deliver selectively polyamine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e0982c5c5489a051b714892e8b4e14
https://doi.org/10.1200/jco.2009.27.15_suppl.11087
https://doi.org/10.1200/jco.2009.27.15_suppl.11087
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3021-3022
The key step of the synthesis of efaroxan was the dihydrobenzofuran ring formation involving an intramolecular cyclization of the tertiary alcohol intermediate with the fluoroaromatic moiety in basic medium. This carbinol was prepared according to tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbe02f5c9cd3de82bc56ebd71fa6d80
https://doi.org/10.1016/s0960-894x(99)00531-4
https://doi.org/10.1016/s0960-894x(99)00531-4
Autor:
J.-M. Barret, M. Broussas, Y. Guminski, C. Bailly, V. Brel, T. Imbert, L. Goetsch, Charles Dumontet, Jean Philippe Annereau, Nicolas Guilbaud
Publikováno v:
European Journal of Cancer Supplements. 6:37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f0f1862013a92a140cdb25cadbe158
https://doi.org/10.1016/s1359-6349(08)72043-3
https://doi.org/10.1016/s1359-6349(08)72043-3
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(2)
CRE 10904 [2-(p-fluorophenoxy), 1-(o-hydroxyphenyl)-ethane, the leading compound of a new family of loop diuretic and antihypertensive agents: 1-aryl, 2-aryloxy-ethanes] induced high-ceiling natriuretic action in dogs and rats, but was completely ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0d0ff49430950c3b62153b30181f812
https://pubmed.ncbi.nlm.nih.gov/2243333
https://pubmed.ncbi.nlm.nih.gov/2243333