Výsledky vyhledávání - "T. I. Kalman"

Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole

Autor: V, Cody, J R, Luft, E, Ciszak, T I, Kalman, J H, Freisheim

Publikováno v: Anti-cancer drug design. 7(6)

The crystal structure of the methotrexate-gamma-tetrazole (MTXT)-NADPH ternary complex with recombinant human dihydrofolate reductase (DHFR) has been determined and refined to R = 15.9% for 7003 data from 10.0 to 2.3 A resolution for the R3 lattice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12429b7398536843d0dfdacb448a5ea2
https://pubmed.ncbi.nlm.nih.gov/1285840

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A New Look at the Molecular Mechanism of Thymidylate Synthase and Its Interaction with Nucleotide Analogues

Autor: D. A. Matthews, T. I. Kalman

Publikováno v: Nucleosides and Nucleotides. 18:843-844

The increasing availability of the crystal structures of a variety of complexes of thymidylate synthase1 (TS) and its mutants with nucleotide and folate analogues, has greatly advanced our understanding of the mechanism of catalysis, and the detailed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f4ab16f5ec3cf9bbd4dd5fa44000976
https://doi.org/10.1080/15257779908041576

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Autor: T. I. Kalman

Publikováno v: Nucleosides and Nucleotides. 18:845-846

Thymidylate synthase (TS) and inosine 5′-monophosphate dehydrogenase (IMPDH) are important targets of drug action and development. The two enzymes bear no structural resemblance to each other and they catalyze fundamentally different chemical react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7fbd7477e12f5cb1615b6f451c84947
https://doi.org/10.1080/15257779908041577

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Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group

Autor: J J, McGuire, C A, Russell, W E, Bolanowska, C M, Freitag, C S, Jones, T I, Kalman

Publikováno v: Cancer research. 50(6)

The biological activities of novel analogues of methotrexate (MTX) and aminopterin (AMT) in which the gamma-carboxyl was replaced by a 1H-tetrazol-5-yl ring, an isosteric group with acidic properties similar to a carboxyl group, were investigated. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8d1c6b1262ed407fab0f9b0ff2b9ba7
https://pubmed.ncbi.nlm.nih.gov/2306727

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Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate

Autor: T. J. Bardos, T. I. Kalman, Seyuen Choi

Publikováno v: Journal of Medicinal Chemistry. 22:618-621

5-Selenium-substituted derivatives (diselenides) or uracil, 2'-deoxyuridine, and 2'-deoxyuridylic acid were synthesized via the addition of methyl hypobromite to the 5,6 double bond, followed by reaction of the adducts with sodium diselenide. The phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6abc504f46ee55129069697b978e08
https://doi.org/10.1021/jm00192a004

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