Výsledky vyhledávání - "T. H. Althuis"

Structure-activity relationships in a series of novel 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylic acid antiallergy agents

Autor: Leonard J. Czuba, P. F. Moore, T. H. Althuis, S. B. Kadin, H.-J. Hess

Publikováno v: Journal of Medicinal Chemistry. 23:262-269

A series of more than 50 new 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylic acid derivatives and related compounds with substituent variations at the 2, 3, and 5--9 positions was prepared and evaluated for antiallergy activity using the rat P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c8ec165e1f5fd6b8e96e2b08bfcd00
https://doi.org/10.1021/jm00177a010

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Akademický článek

Microwave Irradiation–Mediated Synthesis of New Substituted Pyridopyrimidines via the Suzuki–Miyaura Coupling Reaction and Biological Evaluation.

Autor: Riadi, Yassine¹ (AUTHOR), Geesi, Mohammed H.² (AUTHOR), Dehbi, Oussama³ (AUTHOR), Ibnouf, Elmutasim O.^4,5 (AUTHOR)

Publikováno v: Polycyclic Aromatic Compounds. 2023, Vol. 43 Issue 4, p3175-3181. 7p.

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ChemInform Abstract: DEVELOPMENT OF ETHYL 3,4-DIHYDRO-4-OXOPYRIMIDO(4,5-B)QUINOLINE-2-CARBOXYLATE, A NEW PROTOTYPE WITH ORAL ANTIALLERGY ACTIVITY

Autor: T. H. Althuis, P. F. Moore, H.-J. Hess

Publikováno v: Chemischer Informationsdienst. 10

Structural modification of 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid leading to ethyl 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylate, a new prototype with oral antiallergy activity of the disodium cromoglycate type, is described. This p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1863bc12762a53bef916a5bddcdd87cc
https://doi.org/10.1002/chin.197921260

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Structure-Activity Relationships in a New Class of Pyrimido[4,5-b]quinoline Antiallergy Agents

Autor: T. H. Althuis, Leonard J. Czuba, P. F. Moore, H.-J. Hess, S. B. Kadin

Publikováno v: ACS Symposium Series ISBN: 9780841205369
Drugs Affecting the Respiratory System

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7acb0fa8b0895e1174a8954ed4f80e2
https://doi.org/10.1021/bk-1980-0118.ch003

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Potent analgetics derived from 9-nor-9 beta-hydroxyhexahydrocannabinol

Autor: M R, Johnson, T H, Althuis, J S, Bindra, C A, Harbert, L S, Melvin, G M, Milne

Publikováno v: NIDA research monograph. 34

Based on the report of morphine-like analgetic activity of 9-nor-9 beta-hydroxyhexahydrocannabinol (HHC), we undertook a study of structural modifications of the C-3 side chain of HHC to optimize the analgetic activity. We ultimately examined four di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cd1293e61844fc708ff0dd538336198
https://pubmed.ncbi.nlm.nih.gov/6111753

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ChemInform Abstract: STRUCTURE-ACTIVITY RELATIONSHIPS IN A SERIES OF NOVEL 3,4-DIHYDRO-4-OXOPYRIMIDO(4,5-B)QUINOLINE-2-CARBOXYLIC ACID ANTIALLERGY AGENTS

Autor: H.-J. Hess, Leonard J. Czuba, P. F. Moore, S. B. Kadin, T. H. Althuis

Publikováno v: Chemischer Informationsdienst. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff82452771d537e22444f44df4b827ab
https://doi.org/10.1002/chin.198033244

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ChemInform Abstract: SYNTHESIS AND IDENTIFICATION OF THE MAJOR METABOLITES OF PRAZOSIN FORMED IN DOG AND RAT

Autor: H.-J. Hess, T. H. Althuis

Publikováno v: Chemischer Informationsdienst. 8

The 6-O-demethyl and 7-O-demethyl analogues of the new antihypertensive drug prazosin [2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten-step reaction sequences starti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1db2d910a0a2ff5031758b87554a86
https://doi.org/10.1002/chin.197722254

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