Výsledky vyhledávání - "T. Gooljarsingh"

POS1428 IDENTIFICATION OF A WARM AUTOIMMUNE HEMOLYTIC ANEMIA (wAIHA) POPULATION USING PREDICTIVE ANALYTICS OF A KNOWN CLINICALLY PROFILED COHORT

Autor: K. R. Mccrae, T. Gooljarsingh, G. K. Jones, M. L. Tjoa

Publikováno v: Annals of the Rheumatic Diseases. 81:1057.1-1057

BackgroundThe disease burden of warm autoimmune hemolytic anemia (wAIHA), a rare disorder characterized by the destruction of red blood cells (RBCs) by pathogenic IgG autoantibodies, has not been well studied. At the time this claims database analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f85544cc7771e5d9bd99d234891c783
https://doi.org/10.1136/annrheumdis-2022-eular.2607

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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

Autor: Gregg B. Fields, Frank T. Coppo, Lusong Luo, Lata T. Gooljarsingh, Ami S. Lakdawala, Peter J. Tummino, Richard R. Gontarek

Publikováno v: Protein Science. 17:66-71

Matrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo-skeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438519cd8e548eb1b9b7149fe85bcd64
https://doi.org/10.1110/ps.073130208

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A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

Autor: Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick

Publikováno v: Proceedings of the National Academy of Sciences. 103:7625-7630

Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are currently in clinical trials. Geldanamycin (GA) and its analogues have been reported to bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9463212847a9e81115d757c99e1fd
https://doi.org/10.1073/pnas.0602650103

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-Formyl-DDACTHF)

Autor: Marc A. Labroli, G. Peter Beardsley, Thomas H. Marsilje, Stephen J. Baker, Joel Desharnais, Ali Tavassoli, Joseph Ramcharan, Michael P. Hedrick, Yan Zhang, Stephen J. Benkovic, Lata T. Gooljarsingh, Ian A. Wilson, Dale L. Boger, Qing Jin

Publikováno v: Bioorganic & Medicinal Chemistry. 10:2739-2749

The synthesis of 10-formyl-DDACTHF (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) is reported. Aldehyde 3, the corresponding gamma- and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab0040ee427018bd1a971fa3dc0e170c
https://doi.org/10.1016/s0968-0896(02)00102-5

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Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Autor: Joseph Ramcharan, Stephen J. Benkovic, Mark S. Warren, Paul A. Kitos, Lata T. Gooljarsingh, Nancy-Ellen Haynes, Dale L. Boger

Publikováno v: Bioorganic & Medicinal Chemistry. 5:1831-1838

A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb241e33a823c08832a2cc74b8f04d
https://doi.org/10.1016/s0968-0896(97)00121-1

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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

Autor: Lata T. Gooljarsingh, Michael P. Hedrick, Stephen J. Benkovic, Joel Desharnais, Dale L. Boger, Arthur J. Olson, Thomas H. Marsilje, Ian A. Wilson, Chenglong Li, Ali Tavassoli, Yan Zhang

Publikováno v: Biochemistry. 42(20)

Glycinamide ribonucleotide transformylase (GAR Tfase) has been the target of anti-neoplastic intervention for almost two decades. Here, we use a structure-based approach to design a novel folate analogue, 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3d4b5289daa9f9d18c56da01096835
https://pubmed.ncbi.nlm.nih.gov/12755606

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

Autor: Thomas H, Marsilje, Marc A, Labroli, Michael P, Hedrick, Qing, Jin, Joel, Desharnais, Stephen J, Baker, Lata T, Gooljarsingh, Joseph, Ramcharan, Ali, Tavassoli, Yan, Zhang, Ian A, Wilson, G Peter, Beardsley, Stephen J, Benkovic, Dale L, Boger

Publikováno v: Bioorganicmedicinal chemistry. 10(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::257ac116e490becd10fd11c63d22a918
https://pubmed.ncbi.nlm.nih.gov/12057663

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Localization of GAR transformylase in Escherichia coli and mammalian cells

Autor: Lata T. Gooljarsingh, Stephen J. Benkovic, Joseph Ramcharan, Simon Gilroy

Enzymes of the de novo purine biosynthetic pathway may form a multienzyme complex to facilitate substrate flux through the ten serial steps constituting the pathway. One likely strategy for complex formation is the use of a structural scaffold such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b1b1bb4c5c0128230f04e605c6d27d
https://europepmc.org/articles/PMC34393/

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