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of 58
pro vyhledávání: '"T. Gidalevitz"'
Autor:
J. Alexander-Floyd, S. Haroon, M. Ying, A. A. Entezari, C. Jaeger, M. Vermulst, T. Gidalevitz
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinp
Externí odkaz:
https://doaj.org/article/53e7d9a82a3543b8ba654af115728a70
Additional file 2: Figure S2. Cumulative distribution of unique SNPs across remaining chromosomes. chromosomes II through X in the drxlR1;Q40 strain accumulated up to 160 unique SNPs each. Shown are SNPs remaining after subtraction of the variants pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc93372e1b522888295c6b4d4beffb4
Additional file 9: Data File 1. List of genes in the drxIR1 interval with potentially significant SNPs generated by the SnpEff tool. The nucleotide positions correspond to the N2(Bristol) genome assembly from WormBase release WS220 [131], available i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae031f8730e40eeb07dba0e49aacf71
Additional file 6: Table S2. Candidate genes tested by RNAi. 24 candidate genes present in the target 326 Kb of drxIR1 interval (between SNPs 5 and 6b (Additional file 1: Fig. S1)) are indicated in color. Genes were defined as candidates based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bc96013fbccb2ca2d849823cec6b9f
Additional file 1: Figure S1. Schematic of the drxlR1 interval and SNPs used for mapping. (A) Red: the 1.4 Mb genomic region on chromosome I, containing the DR1350-derived intervals, in the RIL2-derived drxlR1;Q40 strain and the four remaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052755820a1d277daf4c4b2b0757d929
Additional file 8: Table S4. Primers used for generating RNAi clones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f12ae7d6e84ccb6f21a0db3b49f1550
Additional file 7: Table S3. Primers used for genotyping the drxIR1 locus and for qPCR analysis of atg-5 expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a0ea3338d030889ef5cf2b9c9f3630
Additional file 3: Figure S3. Controls for the basal proteostasis effects of the drxIR1 locus. (A) The UbG76V::Dendra2 proteasome reporter is sensitive to decreased proteasome levels. Knockdown of a proteasome subunit rpn-6.1, via RNAi, increased the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dba3bc615e9379cc06e591085cea5bd
Additional file 4: Figure S4. The drxIR1 interval decreases accumulation of polyQ67 aggregates in the neurites. (A) Outline of the head of an individual animal, with intestine (int) and pharynx (ph) indicated. Anterior to the left, dorsal up. Green s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e90ac53ce107f9a1fe20903ba7e1ec
Additional file 5: Table S1. Loss-of-function analysis for the RIL2-like head aggregation phenotype. sDP2 free duplication covers most of the left arm of chromosome I, extending through dpy-5 marker but not through unc-13. drxIR1;Q40 animals were cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0bfbcc14e8266859046a18cdebd123