Zobrazeno 1 - 6
of 6
pro vyhledávání: '"T. Geoffrey C. Bird"'
Autor:
R. M. Mcmillan, Pierre Andre Raymond Bruneau, John F. Kingston, T. Geoffrey C. Bird, Graham Charles Crawley, Martin Paul Edwards, Jean Marc Girodeau, S. J. Foster
Publikováno v:
Journal of medicinal chemistry. 34(7)
(Methoxyalkyl)thiazoles are novel 5-lipoxygenase (5-LPO) inhibitors that are neither redox agents nor iron chelators. Consideration of a hypothetical model of the enzyme active site led to this series which is exemplified by 1-[3-(naphth-2-ylmethoxy)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f059b5864a3c875d21a2932bceb544
https://pubmed.ncbi.nlm.nih.gov/1648621
https://pubmed.ncbi.nlm.nih.gov/1648621
Autor:
T. Geoffrey C. Bird, Wolfgang Oppolzer
Publikováno v:
Helvetica Chimica Acta. 62:1199-1202
The photoaddition, hydrolysis, retro-aldol sequences 1 2 3 and 4 5 + 6 7 proceeded in high yield and in a regiospecific manner. However, the enol acetate 8 on irradiation furnished the tricyclic ketoacetate 9 as the major product, presumably by a hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f7b4cbd4485c0f29e1319cf725993d
https://doi.org/10.1002/hlca.19790620429
https://doi.org/10.1002/hlca.19790620429
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :750-755
A series of monofluoro- and gem-difluoro-5α-androstanones and the parent ketones were incubated, under standard conditions, with the fungi named in the title. The results may be rationalised by comparing the positions of the fluorine atoms in the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb1940a09c84d8458f133a82cc0d2f6
https://doi.org/10.1039/p19800000750
https://doi.org/10.1039/p19800000750
Publikováno v:
Helvetica Chimica Acta. 62:2017-2021
1,3-Dihydroisothianaphthen-2,2-dioxide (1) was readily converted to the 1-substituted sulfones 3 by deprotonation and subsequent electrophilic attack (Scheme 3 and Table). The appropriate 1-alkenyl- and 1-alkenoyl-sulfones 3 on heating at 213° to 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313f4ce3968083021feb56c477a3bc7f
https://doi.org/10.1002/hlca.19790620630
https://doi.org/10.1002/hlca.19790620630
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :65
Hydroxy-ketones in the 5α-androstane series are converted into fluoro-ketones by diethylaminosulphur trifluoride under mild conditions; acetoxy-ketones give acetoxydifluorides under more vigorous conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718b6ad633c5fbaaf4bbbfb3a9f52a98
https://doi.org/10.1039/c39790000065
https://doi.org/10.1039/c39790000065
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1533
Efficient methods for the preparation of the compounds listed in the title have been developed. Examination of their 1H n.m.r. spectra showed that in these substituted dihydronaphthalenes the ring containing the olefinic bond is conformationally mobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b20bc4ea4e589e98ac1b96c75d7592c
https://doi.org/10.1039/p19780001533
https://doi.org/10.1039/p19780001533