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Development and Use of a Micro Optical Blood Flow Sensor Based on Systemin Package (SIP) Technology that Fuses Optical MEMS and Integrated Circuit to Detect Avian Influenza

Autor: Eiji Higurashi, R. Seto, Toshihiro Itoh, Ryutaro Maeda, Tsuyoshi Ikehara, T. Masuda, K. Suzuki, T. Fujitsu, Kei Tsukamoto, Renshi Sawada

Publikováno v: TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference.

Based on system-in-package (SiP) technologies that fuse a micromachined optical Doppler blood-flow sensor chip and integrated electronic circuit (IC) chips, very small wireless blood-flow sensors to be attached to birds have been fabricated. Because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172fc738a8c71e278da3c32a5cbd48c4
https://doi.org/10.1109/sensor.2007.4300543

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Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin

Autor: Manami Kobayashi, S. Sakuma, K. Shimomura, Takayoshi Kuno, T. Fujimura, T. Fujitsu, K. Iwasaki, Chisato Tanaka, Kyoko Nakamura, Kouichi Tamura

Publikováno v: Biochemical and biophysical research communications. 202(1)

Tacrolimus(FK506) is a strong immuno-suppressant and shows its activity through inhibiting IL-2 mRNA transcription by forming pentameric complex with intracellular receptor(FK506 binding protein 12 kDa or FKBP12), Ca2+, calmodulin, and calcineurin. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33deb4390a5f8532090c5420779c3aa
https://pubmed.ncbi.nlm.nih.gov/7518678

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Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone

Autor: K, Iwasaki, T, Shiraga, K, Nagase, Z, Tozuka, K, Noda, S, Sakuma, T, Fujitsu, K, Shimatani, A, Sato, M, Fujioka

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(6)

To characterize structures and biological activities of FK506 metabolites, FK506 was incubated with liver microsomes prepared from phenobarbital-treated rats in the presence of NADPH generating system under aerobic condition. Oxidative metabolites fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0edb1c13158bfd4ee41669e5db7ea70
https://pubmed.ncbi.nlm.nih.gov/7507815

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Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity

Autor: N Seki, Y Sudo, T Yoshioka, S Sugihara, T Fujitsu, S Sakuma, T Ogawa, T Hamaoka, H Senoh, H Fujiwara

Publikováno v: The Journal of Immunology. 140:1477-1484

Immunization of DBA/1 mice with type II collagen resulted in typical and progressive arthritis, which is associated with the production of high titer of anti-collagen antibody and the induction of cell-mediated immunity as exemplified by delayed type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cac7a1f932ddcb43f5d1d71b0649c3e
https://doi.org/10.4049/jimmunol.140.5.1477

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