Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones

Autor: María Luisa León, Esperanza Herreros, Santiago Ferrer, Jeremy N. Burrows, Félix Calderón, Milagros Lorenzo, Adolfo García-Pérez, Jorge Fernández, Beatriz Hernández Díaz, María T. Fraile, Iñigo Angulo-Barturen, Jesús Chicharro, Jose M. Fiandor, Juan C. de la Rosa, Mercedes García, Anas Saadeddin, Margarita Puente, Jose M. Bueno, Araceli Mallo

Publikováno v: Journal of medicinal chemistry. 61(8)

Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs (arte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3440fda70b393d49dfa59715f5b0016b
https://pubmed.ncbi.nlm.nih.gov/29589932

Prevalence of Trypanosoma cruzi infection in pregnant Latin American women and congenital transmission rate in a non-endemic area: the experience of the Valencian Health Programme (Spain)

Autor: C. Barona-Vilar, A. Fullana-Montoro, C. González-Steinbauer, C. Parada, A. Gil-Brusola, A. Perez-Tamarit, T. Fraile, D. Bravo, L. Fernandez-Silveira, M. J. Giménez-Martí, D. Navarro, R. Borrás, M. D. Gómez

Publikováno v: Epidemiol Infect
EPIDEMIOL INFECT
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

SUMMARYThis study describes the results of the health programme implemented in the Valencian Community (Spain) to achieve an early diagnosis of Chagas disease in pregnant Latin American women and their newborns. During 2009 and 2010, 1975 women livin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fabd00390e2bf6b6757f93564a45972
https://doi.org/10.1017/s0950268811002482

A new in vivo screening paradigm to accelerate antimalarial drug discovery

Autor: Jose F. Garcia-Bustos, Santiago Ferrer, Didier Leroy, Esther Fernández, Javier Ibáñez, Noemí Magán-Marchal, Teresa Mulet, Leonard D. Shultz, María T. Fraile, Vanessa Gómez, María Belén Jiménez-Díaz, Francisco-Javier Gamo, Félix Calderón, Antonio Martinez, Lorena Cortés-Gil, Sara Viera, Iñigo Angulo-Barturen, David Matthew Wilson, Helen Garuti

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66967 (2013)
PLoS ONE

The emergence of resistance to available antimalarials requires the urgent development of new medicines. The recent disclosure of several thousand compounds active in vitro against the erythrocyte stage of Plasmodium falciparum has been a major break

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd993a90d6d950b6b872aec741363565
http://europepmc.org/articles/PMC3692522?pdf=render

Potent antimalarial 4-pyridones with improved physico-chemical properties

Autor: Santiago Ferrer, María T. Fraile, Jose M. Bueno, Jesús Chicharro, Domingo Gargallo-Viola, Esperanza Herreros, María C. García, Rubén M. Gómez, Jose Luis Lavandera, J. Vidal, Margarita Puente, Jose M. Fiandor, Adolfo García, Pilar Manzano, Milagros Lorenzo

Publikováno v: Bioorganicmedicinal chemistry letters. 21(18)

Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2e2bb1ca5b3c1c30877e5a4f5588c1
https://pubmed.ncbi.nlm.nih.gov/21824778

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