Zobrazeno 1 - 8
of 8
pro vyhledávání: '"T. F. Seeger"'
Autor:
T, Rosen, T F, Seeger, S, McLean, M C, Desai, K J, Guarino, D, Bryce, K, Pratt, J, Heym, P M, Chalabi, J H, Windels
Publikováno v:
Journal of Medicinal Chemistry. 36:3197-3201
The synthesis of a highly potent and selective NK 1 receptor antagonist radioligand, [ 3 H] -cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine (6a) is described. The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a950b9db5c8a1ccce62eaf84d5f823ec
https://doi.org/10.1021/jm00073a022
https://doi.org/10.1021/jm00073a022
Autor:
T F, Seeger, P A, Seymour, A W, Schmidt, S H, Zorn, D W, Schulz, L A, Lebel, S, McLean, V, Guanowsky, H R, Howard, J A, Lowe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
Ziprasidone (CP-88,059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of antipsychotic activity. Whereas the compound is a dopamine antagonist in vitro and in vivo, its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f0136d69e8f80db8e60dd3baa418c0e
https://pubmed.ncbi.nlm.nih.gov/7562537
https://pubmed.ncbi.nlm.nih.gov/7562537
Autor:
K. G. Pratt, R. M. Snider, K. P. Longo, J. A. Lowe, S. McLean, Heidi A. Woody, Dianne K. Bryce, Jon Bordner, Wesley Lebel, S. E. Drozda, T. F. Seeger, J. W. Constantine
Publikováno v:
Peptides ISBN: 9789401050050
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2973b61cebd6f32de38bc755904179aa
https://doi.org/10.1007/978-94-011-2264-1_311
https://doi.org/10.1007/978-94-011-2264-1_311
Autor:
J A, Lowe, T F, Seeger, A A, Nagel, H R, Howard, P A, Seymour, J H, Heym, F E, Ewing, M E, Newman, A W, Schmidt, J S, Furman
Publikováno v:
Journal of medicinal chemistry. 34(6)
The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44d7af11a08a33ac9b6a5a8de7bf92c
https://pubmed.ncbi.nlm.nih.gov/1676427
https://pubmed.ncbi.nlm.nih.gov/1676427
Autor:
T, Rosen, T F, Seeger, S, McLean, A A, Nagel, J L, Ives, K J, Guarino, D, Bryce, J, Furman, R W, Roth, P M, Chalabi
Publikováno v:
Journal of medicinal chemistry. 33(11)
4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritiated 5 and its binding profile in neuroblastoma-glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44ba59a4c982c74ebf80c9e12cc3dccd
https://pubmed.ncbi.nlm.nih.gov/2231600
https://pubmed.ncbi.nlm.nih.gov/2231600
Publikováno v:
Proceedings of the National Academy of Sciences. 81:635-639
The quantitative 2-deoxy[14C]glucose method was used to determine local cerebral glucose utilization in unrestrained rats responding (lever-press) for rewarding electrical stimulation to area A10 (ventral tegmental area) and in similarly implanted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5bd7adb5608a304877346d9653af3d
https://doi.org/10.1073/pnas.81.2.635
https://doi.org/10.1073/pnas.81.2.635
Publikováno v:
Medicine and science in sports and exercise. 18(4)
The effects of prolonged swim-stress (2 h and 1 h) upon brain opioid receptor binding of tritiated [3H]diprenorphine were investigated in male Sprague-Dawley rats. This was accomplished by injecting the label intravenously immediately following the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2de3cdab5ec44e50f66a1293350c17e3
https://pubmed.ncbi.nlm.nih.gov/3018423
https://pubmed.ncbi.nlm.nih.gov/3018423
Autor:
E L, Gardner, T F, Seeger
Publikováno v:
Biological psychiatry. 18(12)
The ability of chronic treatment with the atypical neuroleptic clozapine to induce functional dopaminergic hypersensitivity in laboratory rats was assessed. The intracranial electrical self-stimulation paradigm, known to be sensitive to changes in fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68edf735ff0c748b506e606b07d38e42
https://pubmed.ncbi.nlm.nih.gov/6661466
https://pubmed.ncbi.nlm.nih.gov/6661466