Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer

Autor: Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Bryan G. Allen, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath

Publikováno v: bioRxiv

Thioredoxin Reductase (TrxR) is a key enzyme in reactive oxygen species (ROS) detoxification and in redox regulation. Because cancer cells produce increased steady-state levels of ROS (i.e., superoxide and hydrogen peroxide), TrxR is viable target in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db2b29a43eee17c37e62aa5bb71f97e
https://doi.org/10.1101/2023.05.07.539772

Abstract 5034: Targeting CXCR4 and thioredoxin reductase in high grade neuroendocrine tumors and neuroendocrine carcinomas

Autor: Melissa A. Fath, Dijie Liu, Claudia Robles-Planells, Jordan T. Ewald, Keegan A. Christensen, Spenser S. Johnson, Stephen A. Graves, Douglas R. Spitz, Yusuf Menda, M. Sue O’Dorisio

Publikováno v: Cancer Research. 83:5034-5034

Introduction/Background: Atypical lung carcinoids and lung neuroendocrine carcinomas (NECs) are currently incurable. Most of these cancers express the C-X-C chemokine receptor 4 (CXCR4), making CXCR4 an attractive target for cancer diagnosis and trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37c03d943a083aa4b2628c80b04602bd
https://doi.org/10.1158/1538-7445.am2023-5034

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Hölder Regularity of Geometric Subdivision Schemes

Autor: M. Sabin, T. Ewald, Ulrich Reif

Publikováno v: Constructive Approximation. 42:425-458

We present a framework for analyzing nonlinear $$\mathbb {R}^d$$ -valued subdivision schemes which are geometric in the sense that they commute with similarities in $$\mathbb {R}^d$$ . It allows us to establish $$C^{1,\alpha }$$ -regularity for arbit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce6bf42a235c1b7f2ac79140fec85d2c
https://doi.org/10.1007/s00365-015-9305-3

Experimental research on the TCV tokamak

Autor: B.P. Duval, A. Abdolmaleki, M. Agostini, C.J. Ajay, S. Alberti, E. Alessi, G. Anastasiou, Y. Andrèbe, G.M. Apruzzese, F. Auriemma, J. Ayllon-Guerola, F. Bagnato, A. Baillod, F. Bairaktaris, L. Balbinot, A. Balestri, M. Baquero-Ruiz, C. Barcellona, M. Bernert, W. Bin, P. Blanchard, J. Boedo, T. Bolzonella, F. Bombarda, L. Boncagni, M. Bonotto, T.O.S.J. Bosman, D. Brida, D. Brunetti, J. Buchli, J. Buerman, P. Buratti, A. Burckhart, D. Busil, J. Caloud, Y. Camenen, A. Cardinali, S. Carli, D. Carnevale, F. Carpanese, M. Carpita, C. Castaldo, F. Causa, J. Cavalier, M. Cavedon, J.A. Cazabonne, J. Cerovsky, B. Chapman, M. Chernyshova, P. Chmielewski, A. Chomiczewska, G. Ciraolo, S. Coda, C. Colandrea, C. Contré, R. Coosemans, L. Cordaro, S. Costea, T. Craciunescu, K. Crombe, A. Dal Molin, O. D’Arcangelo, D. de Las Casas, J. Decker, J. Degrave, H. de Oliveira, G.L. Derks, L.E. di Grazia, C. Donner, M. Dreval, M.G. Dunne, G. Durr-Legoupil-Nicoud, B. Esposito, T. Ewalds, M. Faitsch, M. Farník, A. Fasoli, F. Felici, J. Ferreira, O. Février, O. Ficker, A. Frank, E. Fransson, L. Frassinetti, L. Fritz, I. Furno, D. Galassi, K. Gałązka, J. Galdon-Quiroga, S. Galeani, C. Galperti, S. Garavaglia, M. Garcia-Munoz, P. Gaudio, M. Gelfusa, J. Genoud, R. Gerrú Miguelanez, G. Ghillardi, M. Giacomin, L. Gil, A. Gillgren, C. Giroud, T. Golfinopoulos, T. Goodman, G. Gorini, S. Gorno, G. Grenfell, M. Griener, M. Gruca, T. Gyergyek, R. Hafner, M. Hamed, D. Hamm, W. Han, G. Harrer, J.R. Harrison, D. Hassabis, S. Henderson, P. Hennequin, J. Hidalgo-Salaverri, J-P. Hogge, M. Hoppe, J. Horacek, A. Huber, E. Huett, A. Iantchenko, P. Innocente, C. Ionita-Schrittwieser, I. Ivanova Stanik, M. Jablczynska, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A.E. Järvinen, J. Kalis, R. Karimov, A.N. Karpushov, K. Kavukcuoglu, J. Kay, Y. Kazakov, J. Keeling, A. Kirjasuo, J.T.W. Koenders, P. Kohli, M. Komm, M. Kong, J. Kovacic, E. Kowalska-Strzeciwilk, O. Krutkin, O. Kudlacek, U. Kumar, R. Kwiatkowski, B. Labit, L. Laguardia, E. Laszynska, A. Lazaros, K. Lee, E. Lerche, B. Linehan, D. Liuzza, T. Lunt, E. Macusova, D. Mancini, P. Mantica, M. Maraschek, G. Marceca, S. Marchioni, A. Mariani, M. Marin, A. Marinoni, L. Martellucci, Y. Martin, P. Martin, L. Martinelli, F. Martinelli, J.R. Martin-Solis, S. Masillo, R. Masocco, V. Masson, A. Mathews, M. Mattei, D. Mazon, S. Mazzi, S.Y. Medvedev, C. Meineri, A. Mele, V. Menkovski, A. Merle, H. Meyer, K. Mikszuta-Michalik, I.G. Miron, P.A. Molina Cabrera, A. Moro, A. Murari, P. Muscente, D. Mykytchuk, F. Nabais, F. Napoli, R.D. Nem, M. Neunert, S.K. Nielsen, A. Nielsen, M. Nocente, S. Noury, S. Nowak, H. Nyström, N. Offeddu, S. Olasz, F. Oliva, D.S. Oliveira, F.P. Orsitto, N. Osborne, P. Oyola Dominguez, O. Pan, E. Panontin, A.D. Papadopoulos, P. Papagiannis, G. Papp, M. Passoni, F. Pastore, A. Pau, R.O. Pavlichenko, A.C. Pedersen, M. Pedrini, G. Pelka, E. Peluso, A. Perek, C. Perez Von Thun, F. Pesamosca, D. Pfau, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, U. Plank, V. Plyusnin, Y.R.J. Poels, G.I. Pokol, J. Poley-Sanjuan, M. Poradzinski, L. Porte, C. Possieri, A. Poulsen, M.J. Pueschel, T. Pütterich, V. Quadri, M. Rabinski, R. Ragona, H. Raj, A. Redl, H. Reimerdes, C. Reux, D. Ricci, M. Riedmiller, S. Rienäcker, D. Rigamonti, N. Rispoli, J.F. Rivero-Rodriguez, C.F. Romero Madrid, J. Rueda Rueda, P.J. Ryan, M. Salewski, A. Salmi, M. Sassano, O. Sauter, N. Schoonheere, R.W. Schrittwieser, F. Sciortino, A. Selce, L. Senni, S. Sharapov, U.A. Sheikh, B. Sieglin, M. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, E.R. Solano, C. Sozzi, M. Spolaore, L. Spolladore, A. Stagni, P. Strand, G. Sun, W. Suttrop, J. Svoboda, B. Tal, T. Tala, P. Tamain, M. Tardocchi, A. Tema Biwole, A. Tenaglia, D. Terranova, D. Testa, C. Theiler, A. Thornton, A.S. Thrysoe, M. Tomes, E. Tonello, H. Torreblanca, B. Tracey, M. Tsimpoukelli, C. Tsironis, C.K. Tsui, M. Ugoletti, M. Vallar, M. van Berkel, S. van Mulders, M. van Rossem, C. Venturini, M. Veranda, T. Verdier, K. Verhaegh, L. Vermare, N. Vianello, E. Viezzer, F. Villone, B. Vincent, P. Vincenzi, I. Voitsekhovitch, L. Votta, N.M.T. Vu, Y. Wang, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, S. Wiesen, M. Wiesenberger, T. Wijkamp, C. Wüthrich, D. Yadykin, H. Yang, V. Yanovskiy, J. Zebrowski, P. Zestanakis, M. Zuin, M. Zurita

Publikováno v: Nuclear Fusion, Vol 64, Iss 11, p 112023 (2024)

Tokamak à configuration variable (TCV), recently celebrating 30 years of near-continual operation, continues in its missions to advance outstanding key physics and operational scenario issues for ITER and the design of future power plants such as DE

Externí odkaz: https://doaj.org/article/7c1d98abdb744df98cd1957331f779cd