Zobrazeno 1 - 10
of 91
pro vyhledávání: '"T. Ekblad"'
Autor:
Herwig Schüler, T. Ekblad, Tomas Nyman, Anders E. G. Lindgren, Mikael Elofsson, Patricia Verheugd
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(4)
Macrodomains recognize intracellular adenosine diphosphate (ADP)-ribosylation resulting in either removal of the modification or a protein interaction event. Research into compounds that modulate macrodomain functions could make important contributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52bf382ededb81ed94ceeb6fa5fa843
https://pubmed.ncbi.nlm.nih.gov/29316839
https://pubmed.ncbi.nlm.nih.gov/29316839
Autor:
Jonathan Hall, Florent Samain, Herwig Schüler, Susanne Gräslund, T. Ekblad, Davor Bajic, Nan Zhong, Peter Brown, Mauro Zimmermann, Raphael M. Franzini, Dario Neri, Angela Nauer, Jörg Scheuermann, Willy Decurtins, Gediminas Mikutis
Publikováno v:
Journal of medicinal chemistry
We describe the synthesis and screening of a DNA-encoded chemical library containing 76230 compounds. In this library, sets of amines and carboxylic acids are directly linked producing encoded compounds with compact structures and drug-like propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5594c9abfe32f054f2bce58be4089b
Autor:
Tobias Karlberg, A.F. Pinto, T. Ekblad, Lionel Trésaugues, Ann Gerd Thorsell, Michael S. Cohen, Herwig Schüler, Martin Moche, Mirjam Löw
Publikováno v:
Journal of Medicinal Chemistry. 62:5922-5922
Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research tools for their inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdb5ac6beb861eef71dea42c52f2d7f
https://doi.org/10.1021/acs.jmedchem.9b00852
https://doi.org/10.1021/acs.jmedchem.9b00852
Akademický článek
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Publikováno v:
FEBS Journal. 280:3563-3575
Inhibition of ADP-ribosyltransferases with diphtheria toxin homology (ARTD), widely known as the poly(ADP-ribose) polymerase (PARP) family, is a strategy under development for treatment of various conditions, including cancers and ischemia. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc0a3c8583910cbab6d4fcdfcf3f8ff
https://doi.org/10.1111/febs.12298
https://doi.org/10.1111/febs.12298
Autor:
A.F. Pinto, Mirjam Löw, Ann Gerd Thorsell, T. Ekblad, Herwig Schüler, Martin Moche, Tobias Karlberg, Michael S. Cohen, Lionel Trésaugues
Publikováno v:
Journal of medicinal chemistry. 60(4)
Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research tools for their inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adc90995b88a96eda81dd9a2fae7d3f
https://pubmed.ncbi.nlm.nih.gov/31242737
https://pubmed.ncbi.nlm.nih.gov/31242737
Autor:
Johan Weigelt, Anna Linusson, Tobias Karlberg, Urszula Uciechowska, Herwig Schüler, C. David Andersson, Mikael Elofsson, Anders E. G. Lindgren, T. Ekblad, Ann-Gerd Thorsell, Sara Spjut, Pernilla Wittung-Stafshede, Moritz S. Niemiec
Publikováno v:
Journal of Medicinal Chemistry. 55:7706-7718
The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that catalyzes the transfer of ADP-ribose units onto substrate proteins by using nicotinamide adenine dinucleotide (NAD(+)) as a cosubstrate. They have a documented role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d9d3b12591daa0208e59e92f9a9387
https://doi.org/10.1021/jm300746d
https://doi.org/10.1021/jm300746d
Autor:
Herwig Schüler, J. Weigelt, Antonio Macchiarulo, Delal Öncü, Ann-Gerd Thorsell, Roberto Pellicciari, Björn Kull, T. Ekblad, Elisabet Wahlberg, Ewa Pol, Åsa Frostell, Tobias Karlberg, Graeme M. Robertson, N. Markova, Ekaterina Kouznetsova
Publikováno v:
Nature Biotechnology. 30:283-288
Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials as cancer therapeutics, yet the specificity of many of these compounds is unknown. Here we evaluated a series of 185 small-molecule inhibitors, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c25e1488947e8761f7d72305146511e
https://doi.org/10.1038/nbt.2121
https://doi.org/10.1038/nbt.2121
Autor:
Herwig Schüler, T. Ekblad
Publikováno v:
Chemical biologydrug design. 87(3)
PARP-family ADP-ribosyltransferases (PARPs) and sirtuin deacetylases all use NAD(+) as cosubstrate for ADP-ribosyl transfer. PARP inhibitors are important research tools and several are being evaluated in cancer treatment. With the exception of a few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490e99be582b8f5052c9738877dea192
https://pubmed.ncbi.nlm.nih.gov/26518726
https://pubmed.ncbi.nlm.nih.gov/26518726
Autor:
Herwig Schüler, Martin Moche, Mirjam Klepsch, T. Ekblad, A.F. Pinto, Lionel Trésaugues, Tobias Karlberg, Ann-Gerd Thorsell
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b0aad53e2faa235c8c934f4ed24040
https://doi.org/10.1096/fasebj.29.1_supplement.879.23
https://doi.org/10.1096/fasebj.29.1_supplement.879.23