Zobrazeno 1 - 10 of 17 pro vyhledávání: '"T. E. O'Toole"'
1
The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration
Autor: C S, Buensuceso, D, Woodside, J L, Huff, G E, Plopper, T E, O'Toole
Publikováno v: Journal of Cell Science. 114:1691-1698
The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin (β) subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PKC) that mediate integrin bidir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1764dae671c4adacb14d5e58cdac226b
https://doi.org/10.1242/jcs.114.9.1691
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2
Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors
Autor: T. E. O'toole, Mark H. Ginsberg, Shu Chien, Cheng Zhu, K.-L. P. Sung, M. M. Frojmovic
Publikováno v: Blood. 81:419-423
A biophysical approach was used to directly determine the avidity of the junction between two Chinese hamster ovary (CHO) cells bearing recombinant GpIIb-IIIa in the presence and absence of fibrinogen. Micromanipulation was used to induce conjugation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f4dd4ad3ceaee70c5fbb6d6fc69251b
https://doi.org/10.1182/blood.v81.2.419.419
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3
Platelet glycoprotein IIb-IIIa (alpha IIb beta 3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells
Autor: M M, Frojmovic, T E, O'Toole, E F, Plow, J C, Loftus, M H, Ginsberg
Publikováno v: Blood. 78:369-376
To analyze molecular mechanisms of platelet aggregation, we have studied the aggregation of Chinese hamster ovary (CHO) cells expressing between 1 and 4 x 10(5) recombinant human glycoprotein (GP) IIb-IIIa molecules per cell (A5 cells). These cells a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3c4c2df2c75b644b3c3cae41235656
https://doi.org/10.1182/blood.v78.2.369.bloodjournal782369
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5
'Inside-out' signal transduction inhibited by isolated integrin cytoplasmic domains
Autor: Y P, Chen, T E, O'Toole, T, Shipley, J, Forsyth, S E, LaFlamme, K M, Yamada, S J, Shattil, M H, Ginsberg
Publikováno v: The Journal of biological chemistry. 269(28)
The affinities of integrin alpha beta heterodimers for extracellular ligands are important regulators of cell adhesion. Intracellular signals provoke changes in the integrin extracellular domain resulting in "activation," as manifested by an increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::111ac0a29d1ead942b08feaaa9e5dd8e
https://pubmed.ncbi.nlm.nih.gov/8034576
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7
Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors
Autor: K L, Sung, M M, Frojmovic, T E, O'Toole, C, Zhu, M H, Ginsberg, S, Chien
Publikováno v: Blood. 81(2)
A biophysical approach was used to directly determine the avidity of the junction between two Chinese hamster ovary (CHO) cells bearing recombinant GpIIb-IIIa in the presence and absence of fibrinogen. Micromanipulation was used to induce conjugation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdd4dc41c3bb420b39377b017cb5b988
https://pubmed.ncbi.nlm.nih.gov/8422461
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8
Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura
Autor: K, Fujisawa, P, Tani, T E, O'Toole, M H, Ginsberg, R, McMillan
Publikováno v: Blood. 79(6)
Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder due to antiplatelet autoantibodies, many of which are directed against platelet membrane glycoprotein (GP) IIb-IIIa or GPIb-IX. In a recent study, we described plasma autoantibod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f106aba53c7f90be0ff1c08906c5d251
https://pubmed.ncbi.nlm.nih.gov/1547343
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9
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb
Autor: T E, O'Toole, D, Mandelman, J, Forsyth, S J, Shattil, E F, Plow, M H, Ginsberg
Publikováno v: Science (New York, N.Y.). 254(5033)
Intracellular signaling alters integrin adhesive functions in inflammation, immune responses, hemostasis, thrombosis, and retinal development. By truncating the cytoplasmic domain of alpha IIb, the affinity of integrin alpha IIb beta 3 for ligand was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cfee21dc86bd403f92358ae8981921b
https://pubmed.ncbi.nlm.nih.gov/1948065
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10
Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura
Autor: K, Fujisawa, T E, O'Toole, P, Tani, J C, Loftus, E F, Plow, M H, Ginsberg, R, McMillan
Publikováno v: Blood. 77(10)
Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder due to autoantibodies against platelets that result in their destruction. In some patients, these autoantibodies bind to platelet glycoprotein (GP) IIIa. With the aim of better d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab74a0ca3687d94ef34c83431903e4b4
https://pubmed.ncbi.nlm.nih.gov/1709376
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