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NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response

Autor: J. M. Kim, J. P. Kosak, J. K. Kim, G. Kissling, D. R. Germolec, D. C. Zeldin, J. A. Bradbury, S. J. Baek, T. E. Eling

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

NAG-1/GDF15 is a TGF-β superfamily member with poorly characterized biological activity proposed to inhibit inflammatory cytokine production. Transgenic mice expressing human NAG-1/GDF15 (NAG-1Tg/Lox) are leaner with lower body weight and are resist

Externí odkaz: https://doaj.org/article/f0a26459bd734d339b1985efccb700c8

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Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells

Autor: Robert Alexander, Gadiparthi N. Rao, T E Eling, A S Baas, Marschall S. Runge, W C Glasgow

Publikováno v: Journal of Biological Chemistry. 269:32586-32591

Previous studies from this laboratory and others suggest that arachidonic acid and its metabolites play important roles in a variety of biological processes such as signal transduction, contraction, chemotaxis, and cell growth and differentiation. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f6b6553e63d820a1b05f7c92fbd5a6
https://doi.org/10.1016/s0021-9258(18)31674-0

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Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases

Autor: H, Matsuura, M, Sakaue, K, Subbaramaiah, H, Kamitani, T E, Eling, A J, Dannenberg, T, Tanabe, H, Inoue, J, Arata, A M, Jetten

Publikováno v: The Journal of biological chemistry. 274(41)

Treatment of normal human epidermal keratinocytes (NHEK) with interferon-gamma (IFN-gamma) causes a 9-fold increase in the level of cyclooxygenase-2 (COX-2) mRNA expression. Nuclear run-off assays indicate that this induction is at least partly due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::128e7c25d5ff5cd82ddc720e29fb0e25
https://pubmed.ncbi.nlm.nih.gov/10506169

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Expression of 15-lipoxygenase-1 in human colorectal cancer

Autor: H, Ikawa, H, Kamitani, B F, Calvo, J F, Foley, T E, Eling

Publikováno v: Cancer research. 59(2)

Recently, we reported the induction of reticulocyte type 15-lipoxygenase (15-Lox-1) in a human colorectal carcinoma cell line that had been stimulated by butyrate to undergo apoptosis and cell differentiation (H. Kamitani et al., J. Biol. Chem., 273:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f71670d4151e298ae32438896ef5506b
https://pubmed.ncbi.nlm.nih.gov/9927047

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Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385

Autor: D C, Goodwin, M R, Gunther, L C, Hsi, B C, Crews, T E, Eling, R P, Mason, L J, Marnett

Publikováno v: The Journal of biological chemistry. 273(15)

Tyrosyl radicals have been detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated to participate in cyclooxygenase catalysis. Spectroscopic approaches to elucidate the identity of the radicals have not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8712c8e004af27150353482606af1e0
https://pubmed.ncbi.nlm.nih.gov/9535872

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The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes

Autor: W C, Glasgow, R, Hui, A L, Everhart, S P, Jayawickreme, J, Angerman-Stewart, B B, Han, T E, Eling

Publikováno v: The Journal of biological chemistry. 272(31)

In Syrian hamster embryo (SHE) fibroblasts, epidermal growth factor receptor (EGFR) tyrosine kinase activity regulates the metabolism of endogenous linoleic acid to (13S)-hydroperoxyoctadecadienoic acid (13S)-HPODE). (13S)-HPODE stimulates EGF-depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd0011c9f56ae8b2ea161010cc348871
https://pubmed.ncbi.nlm.nih.gov/9235921

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