Výsledky vyhledávání - "T. E Konakova"

Cellular immune response in infected mice to NSP protein encoded by the negative strand NS RNA of influenza A virus

Autor: Oleg P. Zhirnov, Elena I. Isaeva, Stephan Ludwig, T. E. Konakova, Darisuren Anhlan

Publikováno v: Microbiology Independent Research Journal, Vol 6, Iss 1, Pp 18-27 (2019)
Microbiology Independent Research Journal, Vol 6, Iss 1, Pp 28-36 (2019)

Influenza A virus belongs to a family of enveloped viruses with an RNA genome of negative polarity consisting of 8 RNA segments. The transcription of this RNA genome results in the synthesis of positive-sense mRNAs that translate up to 16 unique vira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e49df7ecc18c2a5b7cdfc03d695f49
https://www.mir-journal.org/jour/article/view/46

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Therapeutic effect of aerosol form of aprotinin against Influenza

Autor: T. E Konakova, I. V Vorobeva, N. O Bokova, O. P Zhirnov, N. A Malyshev, Isaeva Ei

Publikováno v: Epidemiology and Infectious Diseases. 19:10-15

There was studied the therapeutic efficacy ofinhalations ofaerosolform ofaprotinin delivered by a propellant in the metered-dose inhaler (MDI). This clinical trial was performed during the winter-spring outbreak caused with pandemic Influenza H1N1pdm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f265f00e5165889e808d7ea5ccffbe6b
https://doi.org/10.17816/eid40817

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NS1 Protein of Influenza A Virus Down-Regulates Apoptosis

Autor: Hans-Dieter Klenk, T. E. Konakova, Oleg P. Zhirnov, Thorsten Wolff

Publikováno v: Journal of Virology. 76:1617-1625

Wild-type (WT) influenza A/PR/8/34 virus and its variant lacking the NS1 gene (delNS1) have been compared for their ability to mediate apoptosis in cultured cells and chicken embryos. Cell morphology, fragmentation of chromatin DNA, and caspase-depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cbcbbc99352306a852d0d64b5753e5
https://doi.org/10.1128/jvi.76.4.1617-1625.2002

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Caspase-Dependent N-Terminal Cleavage of Influenza Virus Nucleocapsid Protein in Infected Cells

Autor: Wolfgang Garten, Hans-Dieter Klenk, T. E. Konakova, Oleg P. Zhirnov

Publikováno v: Journal of Virology. 73:10158-10163

The nucleocapsid protein (NP) (56 kDa) of human influenza A viruses is cleaved in infected cells into a 53-kDa form. Likewise, influenza B virus NP (64 kDa) is cleaved into a 55-kDa protein with a 62-kDa intermediate (O. P. Zhirnov and A. G. Bukrinsk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616e848dfbf5a3b00cad44c96c88b6fc
https://doi.org/10.1128/jvi.73.12.10158-10163.1999

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Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1

Autor: Irina I. Akopova, Oleg P. Zhirnov, Elena I. Isaeva, Petr O. Ilyinskii, Anatoly D. Altstein, Lyudmila M. Piskareva, T. E. Konakova, Alexander M. Shneider, Galini Thoidis, Alex Kartashov

Publikováno v: Influenza and Other Respiratory Viruses

Background Experimental data accumulated over more than a decade indicate that cross-strain protection against influenza may be achieved by immunization with conserved influenza proteins. At the same time, the efficacy of immunization schemes designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12e8acad7f7d51a2dedb8c4b73a4554
https://pubmed.ncbi.nlm.nih.gov/18784792

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[Characterization of proteolytic cleavage of influenza virus nucleocapsid protein NP in infected cells]

Autor: O P, Zhirnov, T E, Konakova, W, Garten, H D, Klenk

Publikováno v: Voprosy virusologii. 44(6)

Antibodies specific to the N-terminal 34-aminoacid peptide of the major nucleocapsid protein NP of human influenza A viruses were obtained. The NP proteolytic cleavage occurring in infected cells late in infection has been demonstrated using this ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89b1f050f1249700cf77243aae7439ac
https://pubmed.ncbi.nlm.nih.gov/10665065

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