Zobrazeno 1 - 10
of 439
pro vyhledávání: '"T. Dickerson"'
Publikováno v:
Annals of Global Health, Vol 83, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/574b0ddccd454daea818ea0df36589ab
Publikováno v:
Annals of Global Health, Vol 82, Iss 3 (2016)
Externí odkaz:
https://doaj.org/article/58367e4562f94eb8ae7a414b464324d0
Publikováno v:
Annals of Global Health, Vol 80, Iss 3, Pp 201-202 (2014)
Externí odkaz:
https://doaj.org/article/06436d9c5a4647899ef6867f6f787f14
Autor:
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson
Publikováno v:
eLife, Vol 12 (2024)
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion. The KCNK16 gene encodi
Externí odkaz:
https://doaj.org/article/add61f69979043f080ec8914198063ad
Autor:
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)
Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2
Externí odkaz:
https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf
Autor:
Matthew T. Dickerson, Jonathan Evans
Many readers drawn into the heroic tales of J. R. R. Tolkien's imaginary world of Middle-earth have given little conscious thought to the importance of the land itself in his stories or to the vital roles played by the flora and fauna of that land. A
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175069 (2017)
Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca2+ influx, which is modulated by the two-pore-domain K+ (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 d
Externí odkaz:
https://doaj.org/article/0260e18cbfe5473eaddeba30916880f4