Zobrazeno 1 - 10
of 438
pro vyhledávání: '"T. Dickerson"'
Publikováno v:
Annals of Global Health, Vol 83, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/574b0ddccd454daea818ea0df36589ab
Publikováno v:
Annals of Global Health, Vol 82, Iss 3 (2016)
Externí odkaz:
https://doaj.org/article/58367e4562f94eb8ae7a414b464324d0
Autor:
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson
Publikováno v:
eLife, Vol 12 (2024)
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion. The KCNK16 gene encodi
Externí odkaz:
https://doaj.org/article/add61f69979043f080ec8914198063ad
Publikováno v:
Annals of Global Health, Vol 80, Iss 3, Pp 201-202 (2014)
Externí odkaz:
https://doaj.org/article/06436d9c5a4647899ef6867f6f787f14
Autor:
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)
Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2
Externí odkaz:
https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Autor:
Jeanette R. Nelson, Rebekah H. Ess, Ty T. Dickerson, Lisa H. Gren, L. Scott Benson, Stephen O. Manortey, Stephen C. Alder
Publikováno v:
Global Health Action, Vol 15, Iss 1 (2022)
Background Skilled attendance at birth is considered key to accomplishing Sustainable Development Goal (SDG) 3.1 aimed at reducing maternal mortality. Many maternal deaths can be prevented if a woman receives care by skilled health personnel. Materna
Externí odkaz:
https://doaj.org/article/96888041a278415a93cbf46fcc10cac5
Autor:
Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] muta
Externí odkaz:
https://doaj.org/article/33dbdc4478504d16946c60f7af11f097
Autor:
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca
Externí odkaz:
https://doaj.org/article/739b7a2b2b794efa9353527289b42407
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf