Zobrazeno 1 - 10
of 344
pro vyhledávání: '"T. Dexter"'
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) is almost twice as prevalent in men, which has largely been attributed to neuroprotective effect of oestradiol in women. RORA (retinoic acid receptor-related orphan receptor alpha) regulates the transcription of ce
Externí odkaz:
https://doaj.org/article/bca815755fc14aa49f1f7cc08f9b4628
Autor:
Diane Stephenson, Robert Alexander, Varun Aggarwal, Reham Badawy, Lisa Bain, Roopal Bhatnagar, Bastiaan R. Bloem, Babak Boroojerdi, Jackson Burton, Jesse M. Cedarbaum, Josh Cosman, David T. Dexter, Marissa Dockendorf, E. Ray Dorsey, Ariel V. Dowling, Luc J. W. Evers, Katherine Fisher, Mark Frasier, Luis Garcia-Gancedo, Jennifer C. Goldsack, Derek Hill, Janice Hitchcock, Michele T. Hu, Michael P. Lawton, Susan J. Lee, Michael Lindemann, Ken Marek, Nitin Mehrotra, Marjan J. Meinders, Michael Minchik, Lauren Oliva, Klaus Romero, George Roussos, Robert Rubens, Sakshi Sadar, Joseph Scheeren, Eiichi Sengoku, Tanya Simuni, Glenn Stebbins, Kirsten I. Taylor, Beatrice Yang, Neta Zach
Publikováno v:
Digital Biomarkers, Vol 4, Iss 1, Pp 28-49 (2020)
Innovative tools are urgently needed to accelerate the evaluation and subsequent approval of novel treatments that may slow, halt, or reverse the relentless progression of Parkinson disease (PD). Therapies that intervene early in the disease continuu
Externí odkaz:
https://doaj.org/article/02833b80db5e4df4916766e3401c1666
Autor:
Klaus Romero, Daniela Conrado, Jackson Burton, Timothy Nicholas, Vikram Sinha, Sreeraj Macha, Malidi Ahamadi, Jesse Cedarbaum, John Seibyl, Kenneth Marek, Peter Basseches, Derek Hill, Ed Somer, Jill Gallagher, David T. Dexter, Arthur Roach, Diane Stephenson, for the Critical Path for Parkinson's (CPP) Consortium, the Parkinson's Progression Markers Initiative (PPMI)
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 240-246 (2019)
The Critical Path for Parkinson's (CPP) Imaging Biomarker and Modeling and Simulation working groups aimed to achieve qualification opinion by the European Medicines Agency (EMA) Committee for Medical Products for Human Use (CHMP) for the use of base
Externí odkaz:
https://doaj.org/article/947d1d44d90d4ee39519d4068df35b29
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7267 (2022)
Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to synthesise a variety of pro-inflammatory agents which may l
Externí odkaz:
https://doaj.org/article/648481e5abe547e592201e343accc380
Autor:
Antonio Martin-Bastida, Roberta J. Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C. Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R. Crichton, David T. Dexter
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Parkinson’s disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD
Externí odkaz:
https://doaj.org/article/447847d27a3f44eea2861e4c6d11074c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3338 (2021)
Iron loading in some brain regions occurs in Parkinson’s Disease (PD), and it has been considered that its removal by iron chelators could be an appropriate therapeutic approach. Since neuroinflammation with microgliosis is also a common feature of
Externí odkaz:
https://doaj.org/article/b209b2bee7a24cf9a6a5432740dbc78c
Autor:
Ilse S. Pienaar, Cecilia Heyne Lee, Joanna L. Elson, Louisa McGuinness, Stephen M. Gentleman, Raj N. Kalaria, David T. Dexter
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 392-405 (2015)
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an accepted treatment for motor symptoms in a subset of Parkinson's disease (PD) patients. The mechanisms why DBS is effective are incompletely understood, but previous studies
Externí odkaz:
https://doaj.org/article/86cbc8150e8048b786c474f66ca51211
Autor:
Bradley Pearce, Peter Coetzee, Duncan Rowland, Scott Linfoot, David T Dexter, Djordje Gveric, Stephen Gentleman
The identification of Parkinson’s Disease (PD) from post-mortem brain slices is time consuming for highly trained neuropathologists, often taking many hours per case. In this study, we demonstrate fully automatic PD detection, from single 1000um re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79edc7d8d7635fa36f3aac203093f8ef
https://doi.org/10.1101/2022.08.30.505459
https://doi.org/10.1101/2022.08.30.505459
Autor:
Caroline H. Williams-Gray, Diane Stephenson, Klaus Romero, Judith Anton, Ferdous Gheyas, Nathan J. Hanan, Jonas Weidemann, Minhua Yang, Malidi Ahamadi, Massimo Bani, Bob Stafford, Charles S. Venuto, Chao Chen, Vincent Thuillier, Ka Lai Yee, Gennaro Pagano, Monica Javidnia, Sreeraj Macha, Nitin Mehrotra, Vikram Sinha, Kenneth Marek, Yaming Hang, Hans Smit, Anne Pedata, Mussie Akalu, Babak Boroojerdi, David T. Dexter, Glenn T. Stebbins
Publikováno v:
Clinical Pharmacology & Therapeutics. 110:508-518
Leucine-rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as interventions to slow progression of Parkinson's disease (PD). Understanding the rate of progression in PD as measured by both motor and non-motor features is pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9053473f0a3b3a25461e5d893d23049
https://doi.org/10.1002/cpt.2277
https://doi.org/10.1002/cpt.2277
Autor:
Roberta J. Ward, Antonio Martin-Bastida, David T. Dexter, Sukhi Bansal, Bension S. Tilley, Steve M. Gentleman
Publikováno v:
Journal of Neural Transmission. 128:15-25
In these present studies, in vivo and and post-mortem studies have investigated the association between iron and inflammation. Early-stage Parkinson’s disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64de912e030bdffe34e147ac9de6ad71
https://doi.org/10.1007/s00702-020-02271-2
https://doi.org/10.1007/s00702-020-02271-2