Zobrazeno 1 - 10
of 24
pro vyhledávání: '"T. D. Sweeney"'
Publikováno v:
Human Gene Therapy. 11:361-371
Targeting adenoviral vectors for cystic fibrosis gene therapy to the human airways with minimal exposure to alveoli would avoid adverse reactions and maximize response. At present, to deliver gene therapy vectors, large volumes of fluid are instilled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acec99055a3d374e72c1824a59f120a
https://doi.org/10.1089/10430340050016085
https://doi.org/10.1089/10430340050016085
Autor:
A L Tucker, T M Grasso, T D Sweeney, I Gonda, Imre Kovesdi, P M Williams, Ronald G. Crystal, Neil R. Hackett, Ramachandran Ramalingam, Philip L. Leopold, Ben-Gary Harvey, Steven Shak, Robert J. Kaner, Barbara Ferris
Publikováno v:
Journal of Clinical Investigation. 104:1245-1255
We sought to evaluate the ability of an E1(-), E3(-) adenovirus (Ad) vector (Ad(GV)CFTR.10) to transfer the normal human cystic fibrosis transmembrane conductance regulator (CFTR) cDNA to the airway epithelium of individuals with cystic fibrosis (CF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282ade8eea2e590a0a11e8d268b540d4
https://doi.org/10.1172/jci7935
https://doi.org/10.1172/jci7935
Autor:
Holger Schulz, A. Ziesenis, John J. Godleski, S. Haeussermann, J. D. Blanchard, Joachim Heyder, T. D. Sweeney, P. Hutzler, Shinji Takenaka, Wolfgang G. Kreyling
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Long-term retention of particles in airways is controversial. However, precise anatomic localization of the particles is not possible in people. In this study the anatomic location of retained particles after shallow bolus inhalation was determined i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac6f58d31bfaedcd705c08e2793d189
https://doi.org/10.1152/jappl.1999.87.1.269
https://doi.org/10.1152/jappl.1999.87.1.269
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:482-488
Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768f18efe1f23e11d40d4a57fb5227b2
https://doi.org/10.1164/ajrccm.151.2.7842210
https://doi.org/10.1164/ajrccm.151.2.7842210
Publikováno v:
Journal of Aerosol Science. 23:181-184
To compare the initial anatomic sites of particle deposition with the resultant particle clearance kinetics in the lungs, it is desirable to have particles that have both radioactive and fluorescent labels. The radioactivity allows for analysis of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468f39205b6a28d81e6faa38b575c734
https://doi.org/10.1016/0021-8502(92)90379-a
https://doi.org/10.1016/0021-8502(92)90379-a
Autor:
Mary Ellen Avery, Virginia S. Kharasch, John L. Lehr, Andrew I. Damokosh, Joseph D. Brain, T. D. Sweeney, Jeffrey J. Fredberg
Publikováno v:
American Review of Respiratory Disease. 144:909-913
Tracheal instillation of pentamidine in a surfactant vehicle may be an effective direct method of antibiotic delivery to the lungs. In 10 healthy hamsters, we compared the pulmonary distribution of 99mTc sulfur colloid (TcSC) mixed with pentamidine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9e6591c6fdf141524c4ec5b98871c8
https://doi.org/10.1164/ajrccm/144.4.909
https://doi.org/10.1164/ajrccm/144.4.909
Publikováno v:
Journal of Aerosol Science. 21:350-354
We have developed methods that enable us to quantify the amount of drug deposited at specific anatomic locations throughout the respiratory tract. These methods are presented with an example of the results from the delivery of an anti-protease drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba250a5703b0732b5ec0a6ab4c6210b
https://doi.org/10.1016/0021-8502(90)90057-5
https://doi.org/10.1016/0021-8502(90)90057-5
Autor:
J D, Andya, Y F, Maa, H R, Costantino, P A, Nguyen, N, Dasovich, T D, Sweeney, C C, Hsu, S J, Shire
Publikováno v:
Pharmaceutical research. 16(3)
To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized monoclonal antibody.Protein aggregation of spray-dried powders stored at various temperature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68473d79a6b230d1aa098b5b821206f7
https://pubmed.ncbi.nlm.nih.gov/10213364
https://pubmed.ncbi.nlm.nih.gov/10213364
Publikováno v:
Pharmaceutical research. 15(5)
To understand the effect of spray drying and powder processing environments on the residual moisture content and aerosol performance of inhalation protein powders. Also, the long-term effect of storage conditions on the powder's physical and biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f16365ff0dbd3821704d30b19bcbf76e
https://pubmed.ncbi.nlm.nih.gov/9619788
https://pubmed.ncbi.nlm.nih.gov/9619788
Publikováno v:
The Annals of Occupational Hygiene.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c25bb9dfbbee427166c5bd14ead33f9c
https://doi.org/10.1093/annhyg/38.inhaled_particles_vii.235
https://doi.org/10.1093/annhyg/38.inhaled_particles_vii.235