Výsledky vyhledávání - "T. D. Southgate"

Long-Term Transgene Expression within the Anterior Pituitary Glandin Situ: Impact on Circulating Hormone Levels, Cellular and Antibody-Mediated Immune Responses1

Autor: T. D. Southgate, Maria G. Castro, Judith C. Williams, Pedro R. Lowenstein, Daniel Stone

Publikováno v: Endocrinology. 142:464-476

Adenoviral vectors have been identified as useful tools for gene transfer to the pituitary gland with the aim of providing therapeutic treatments for pituitary diseases. Although successful adenovirus-mediated gene transfer to the pituitary has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4524829a6e70d54922bfcfdab9bd3270
https://doi.org/10.1210/endo.142.1.7898

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Adenovirus-mediated gene transfer to human lens epithelial cells in organ culture

Autor: T. D. Southgate, Lisa Saxby, Maria G. Castro, Khaled Abul-Hassan, Louis M Carrington, T. C. Maleniak, Michael E. Boulton

Publikováno v: Journal of Cataract and Refractive Surgery. 26:887-892

Purpose To assess the feasibility of using recombinant adenovirus vectors to transduce the human lens epithelial cells (LECs) involved in posterior capsule opacification (PCO). Setting Department of Ophthalmology and Molecular Medicine Unit, Universi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f001e439ac46d78ec1964882d61275e
https://doi.org/10.1016/s0886-3350(00)00325-4

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Adenoviruses Encoding HPRT Correct the Biochemical Abnormalities Fully Only in HPRT-Deficient Human Cell Lines: Importance of Species Differences

Autor: Pedro R. Lowenstein, H. Anne Simmonds, Adrian E. Morelli, D. Bain, Maria G. Castro, Adroana Larregina, T. D. Southgate, Lynette D. Fairbanks

Publikováno v: Purine and Pyrimidine Metabolism in Man X ISBN: 0306465159

The Lesch-Nyhan syndrome (LNS) is an X-linked disorder caused by a virtually complete absence of the key purine recycling enzyme, hypoxanthine-guanine phosphoribosyltransferase (HPRT) It is characterised by uric acid overproduction and severe neurolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed9befe0ec35a3269aa853d37bb21a2
https://doi.org/10.1007/0-306-46843-3_7

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Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses

Autor: T D, Southgate, D, Stone, J C, Williams, P R, Lowenstein, M G, Castro

Publikováno v: Endocrinology. 142(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e36ebdadca096642f9f70c5830535a6
https://pubmed.ncbi.nlm.nih.gov/11145611

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Cell Type Specific and Inducible Transgenesis in the Anterior Pituitary Gland

Autor: Joseph R. Smith-Arica, Maria G. Castro, Pablo Umana, Andrés Hurtado-Lorenzo, T. D. Southgate, Pedro R. Lowenstein, Judith C. Williams, Daniel Stone

Publikováno v: Transgenic Models in Endocrinology ISBN: 9781461356516

With the recent emergence of the sequence for the human genome, and the inevitable wealth of DNA sequences that will be gathered from it, the use of genetic manipulation as a tool in uncovering the molecular basis of many physiological processes with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffcf5ceaf2b3206a6bea822b55752f1a
https://doi.org/10.1007/978-1-4615-1633-0_11

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Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries

Autor: Marcelo J. Perone, Joseph R. Smith-Arica, Maria G. Castro, Julian R. E. Davis, T. D. Southgate, Christian Gerdes, S. Windeatt, Pedro R. Lowenstein, Ian D. Morris, David Klatzmann

Publikováno v: Endocrinology. 141(9)

The use of pituitary cell type-specific promoters is a powerful molecular tool to achieve pituitary cell type-specific transcriptional targeting of transgenes encoded by viral vectors. It has recently been proposed that transcriptional targeting of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689b628cd1e498712af4cba3f286b20b
https://pubmed.ncbi.nlm.nih.gov/10965923

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Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium

Autor: T D, Southgate, D, Bain, L D, Fairbanks, A E, Morelli, A T, Larregina, H A, Simmonds, M G, Castro, P R, Löwenstein

Publikováno v: Metabolic brain disease. 14(4)

The Lesch-Nyhan syndrome is an X-linked disorder caused by a virtually complete absence of the key enzyme of purine recycling, hypoxanthine-guanine phosphoribosyltransferase (HPRT). It is characterized by uric acid overproduction and severe neurologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aed2e03e6766f781c0b16b6c9d9732f
https://pubmed.ncbi.nlm.nih.gov/10850548

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Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK

Autor: C Cowsill, Z Forrest, Maria G. Castro, Pedro R. Lowenstein, T. D. Southgate, David Klatzmann, Ricardo A Dewey, Gavin William Grahame Wilkinson, T. C. Maleniak, Adrian E. Morelli, G. Morrissey

Publikováno v: Gene therapy. 7(8)

Herpes simplex virus type 1-thymidine kinase (HSV1-TK) in combination with ganciclovir is an efficient and widely used strategy in brain tumour gene therapy. Recently, we have shown effective inhibition of glioma growth in a syngeneic rat model using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951bd8564ab80b73e8e79c3a8d45b26e
https://pubmed.ncbi.nlm.nih.gov/10800091

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Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas

Autor: Maria G. Castro, David Klatzmann, Ricardo A Dewey, Rodolfo G. Goya, T. C. Maleniak, Federico Bolognani, S. Windeatt, T. D. Southgate, Pedro R. Lowenstein, Adriana T. Larregina, Marcelo J. Perone, Ian D. Morris

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(3)

We tested the hypothesis that gene transfer using recombinant adenovirus vectors (RAds) expressing herpes simplex virus type 1 thymidine kinase (HSV1-TK) might offer an alternative therapeutic approach for the treatment of pituitary prolactinomas tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357c215169886418fc5c45afae1612ba
https://pubmed.ncbi.nlm.nih.gov/10720079

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

Autor: N.J.F. Dodd, T. D. Southgate, Pedro R. Lowenstein, C Cowsill, Maria G. Castro, Daniel Stone, David Klatzmann, Ricardo A Dewey, Federico Bolognani, Hans Lassmann, G. Morrissey

Publikováno v: Nature medicine. 5(11)

The long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for gliomas remain uncharacterized. We report here detection of active brain inflammation 3 months after successful inhibition of syngeneic glioma growth. The inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8644b920cfb776962fe9b338469aa6c9
https://pubmed.ncbi.nlm.nih.gov/10545991

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