Výsledky vyhledávání - "T. D. Miniker"

[3-(1H-indol-3-yl)-4-(1-glykozylindol-3-yl)-1H-pyrrole-2,5-diones: synthesis and study of antiproliferative properties]

Autor: S Ia, Mel'nik, A A, Bakhmedova, L D, Garaeva, T D, Miniker, I L, Plikhtiak, L V, Ektova, T P, Ivanova, V M, Adanin, I V, Iartseva

Publikováno v: Bioorganicheskaia khimiia. 22(10-11)

A synthesis of 3-(1H-3-indolyl)-4-(1-glycosyl-3-indolyl)furan-2,5-diones and -1H-pyrrole-2,5-diones modified with the residues of D-ribo-, D-xylo-, L-arabino-, D-galactopyranose, and D-lactose was described. Influence of the compounds prepared on DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::decd233bf0db4f8e5a593e82659b72fb
https://pubmed.ncbi.nlm.nih.gov/9036842

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[Synthesis and antiproliferative properties of glycosides of bis(indolyl)furan-2,5-dione and bis(indolyl)-1H-pyrrol-2,5-dione]

Autor: S Ia, Mel'nik, A A, Bakhmedova, L D, Garaeva, O V, Goriunova, T D, Miniker, I L, Plikhtiak, L V, Ektova, I V, Iartseva

Publikováno v: Bioorganicheskaia khimiia. 22(6)

A synthesis of the derivatives of bis(indolyl)furan and bis(indolyl)pyrrole, which contain an acyclic fragment or a residue of D-ribo-, D-xylo-, L-arabino-, D-galactopyranose, or D-lactose was described. Bis(indole) aglycone was created using 1-glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0dbe99c3419478f7cc1e1991e95e8ca
https://pubmed.ncbi.nlm.nih.gov/8975674

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[Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2'-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase]

Autor: L Iu, Dederer, I S, Sokolova, A A, Bakhmedova, T D, Miniker, S Ia, Mel'nik, L B, Gorbacheva

Publikováno v: Biokhimiia (Moscow, Russia). 60(9)

O6-Methyl-2'-deoxyguanosine (O6-MedG), a novel inhibitor of O6-alkylguanine-DNA alkyltransferase (O6-AGT), has been synthesized. The ability of O6-MedG to deplete the O6-AGT activity in leukemia L1210 and melanoma B16 cells in vivo has been studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cc64a75bf2bdd37729256cf23c719fb
https://pubmed.ncbi.nlm.nih.gov/8562657

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O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo

Autor: Elksne Sj, T. D. Miniker, Gorbacheva Lb, Melnik SYa, Preobrazhenskaya Mn, Kukushkina Gv

Publikováno v: Anti-cancer drugs. 2(2)

The effect of O6-methylguanine (O6-MeG) on the therapeutic efficiency of 1-methyl-1-nitrosourea (MNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against the murine L1210 leukemia and B16 melanoma was studied in vivo. Although the level of O6-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f692473f79695a24000ddbf67af832b8
https://pubmed.ncbi.nlm.nih.gov/1958863

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Aza and deaza analogs of purine nucleosides (review)

Autor: M. N. Preobrazhenskaya, T. D. Miniker

Publikováno v: Chemistry of Heterocyclic Compounds. 17:97-108

Methods for the preparation of aza and deaza analogs of purine nucleosides, viz., nucleosides of imidazo[4,5-d]-v-triazines, imidazo[4,5-b]pyridines, and imidazo[4,5-c]pyridines, and their properties are described. References to the synthesis of nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94d29a91c931f336604be9b9bab0eda4
https://doi.org/10.1007/bf00507234

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Synthesis and study of L-arabinopyranosides of 5- and 6-nitroindoles

Autor: I. V. Yartseva, M. N. Preobrazhenskaya, V. I. Mukhanov, L. V. Ektova, T. D. Miniker, N. D. Chkanikov

Publikováno v: Chemistry of Heterocyclic Compounds. 15:188-193

Condensation of 5- or 6-nitroindoline with L-arabinose gave 1-α-L-arabinopyranosyl-5 (or 6)-nitroindolines, which, after acetylation, dehydrogenation, and removal of the protective groups, are converted to 1-α-L-arabinopyranosyl-5(or 6)-nitroindole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::106edd4a31f29f6ca31855373e76a8fa
https://doi.org/10.1007/bf00480365

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