Výsledky vyhledávání - "T. Clark Brelje"

Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy

Autor: Laurence E. Stout, Nicholas V. Bhagroo, Anthony J. Weinhaus, Robert L. Sorenson, T. Clark Brelje

Publikováno v: Journal of Endocrinology. 193:367-381

Glucokinase activity is increased in pancreatic islets during pregnancy and in vitro by prolactin (PRL). The underlying mechanisms that lead to increased glucokinase have not been resolved. Since glucose itself regulates glucokinase activity in β-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90950ee939d5f75f52018244175009a1
https://doi.org/10.1677/joe-07-0043

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Distinctive Roles for Prolactin and Growth Hormone in the Activation of Signal Transducer and Activator of Transcription 5 in Pancreatic Islets of Langerhans

Autor: Robert L. Sorenson, Nicholas V. Bhagroo, Laurence E. Stout, T. Clark Brelje

Publikováno v: Endocrinology. 145:4162-4175

Although the beta-cells of the pancreatic islets of Langerhans express both prolactin (PRL) and GH receptors, we have observed that PRL is considerably more effective than GH in the up-regulation of islet function in vitro. This study examined whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b1d767ca408391380daee67546b1fc
https://doi.org/10.1210/en.2004-0201

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An Immunohistochemical Approach to Monitor the Prolactin-induced Activation of the JAK2/STAT5 Pathway in Pancreatic Islets of Langerhans

Autor: T. Clark Brelje, Annika M. Svensson, Robert L. Sorenson, Laurence E. Stout, Nicholas V. Bhagroo

Publikováno v: Journal of Histochemistry & Cytochemistry. 50:365-383

SUMMARY This study examined whether an immunohistochemical method examining the subcellular localization of STAT5 could be used to characterize the activation of the JAK2/ STAT5 pathway by prolactin (PRL) in intact cells or tissues. In the Ins-1 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea8ad42b15105e862c8489312187e34
https://doi.org/10.1177/002215540205000308

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Dopamine-synthesizing neurons include the putative H-cell homologue in the mothManduca sexta

Autor: Andre W. DeLorme, Karen A. Mesce, T. Clark Brelje, Kathleen A. Klukas

Publikováno v: The Journal of Comparative Neurology. 430:501-517

The catecholamine dopamine (DA) plays a fundamental role in the regulation of behavior and neurodevelopment across animal species. Uncovering the embryonic origins of neurons that express DA opens a path for a deeper understanding of how DA expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d686fb56e38603fc63479f015032b2a6
https://doi.org/10.1002/1096-9861(20010219)430:4<501::aid-cne1046>3.0.co

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Novel mouse IgG-like immunoreactivity expressed by neurons in the mothManduca sexta: Developmental regulation and colocalization with crustacean cardioactive peptide

Autor: Karen A. Mesce, Kathleen A. Klukas, T. Clark Brelje

Publikováno v: Microscopy Research and Technique. 35:242-264

Immunoglobulin-related molecules have been shown to play important roles in cell-cell recognition events during the development of both vertebrate and invertebrate nervous systems. In the moth, Manduca sexta, we report the presence of novel, mouse, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3617be5488e9688c90460dfb26a47557
https://doi.org/10.1002/(sici)1097-0029(19961015)35:3<242::aid-jemt5>3.0.co

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Akademický článek

Impact of an E-Learning Histology Course on the Satisfaction and Performance of Medical, Nursing and Midwifery Students.

Autor: Gonzalez-Donoso, Alexis^1,2, Jara-Rosales, Sergio³, Rosemblatt, Mariana⁴, Osses, Mónica⁴, Padilla-Meza, Jaime⁴, Godoy-Guzmán, Carlos^1,4,5 carlos.godoy@usach.cl

Publikováno v: International Journal of Morphology. 2024, Vol. 42 Issue 4, p1161-1174. 14p.

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Prominent expression of acidic fibroblast growth factor in motor and sensory neurons

Autor: Markku Pelto-Huikko, Kjell Fuxe, Tomas Hökfelt, Tanja Junttila, Ralf F. Pettersson, Yihai Cao, Robert Elde, Antonio Cintra, T. Clark Brelje

Publikováno v: Neuron. 7:349-364

Several growth factors originally characterized and named for their action on a variety of cells have more recently been suggested to be importantly involved in the development and maintenance of the nervous system. Acidic fibroblast growth factor (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638bb36565798361f177ecda6c043656
https://doi.org/10.1016/0896-6273(91)90288-b

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Role of Prolactin Versus Growth Hormone on Islet BCell Proliferation in Vitro: Implications for Pregnancy*

Autor: Robert L. Sorenson, T. Clark Brelje

Publikováno v: Endocrinology. 128:45-57

This study investigated the effects of homologous rat PRL (rPRL) and rat GH (rGH) on islet growth as indicated by modifications in insulin secretion, islet cell proliferation, and islet volume with neonatal and adult rat islets in vitro. The number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc9b05aa1b271db2ad590042cc911ea
https://doi.org/10.1210/endo-128-1-45

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Beneficial effects of lipids and prolactin on insulin secretion and beta-cell proliferation: a role for lipids in the adaptation of islets to pregnancy

Autor: Nicholas V. Bhagroo, Laurence E. Stout, T. Clark Brelje, Robert L. Sorenson

Publikováno v: The Journal of endocrinology. 197(2)

To meet the increased demand for insulin during pregnancy, the pancreatic islets undergo adaptive changes including enhanced insulin secretion and β-cell proliferation. These changes peak in mid-pregnancy and return to control levels by parturition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052ccd343cb1074d1b5c6c22606a58ee
https://pubmed.ncbi.nlm.nih.gov/18434356

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