Zobrazeno 1 - 10
of 29
pro vyhledávání: '"T. Chris Gamblin"'
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Aging is the primary risk factor for Alzheimer’s disease (AD) and related disorders (ADRDs). Tau aggregation is a hallmark of AD and other tauopathies. Even in normal aging, tau aggregation is found in brains, but in disease states, significantly m
Externí odkaz:
https://doaj.org/article/c852126583cf4810afe160afb768d0e3
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 3, Pp 368-377 (2008)
Hyperphosphorylated tau protein is a major component of neurofibrillary tangles, a prominent intracellular hallmark of Alzheimer's disease. Both hyperphosphorylated tau and neurofibrillary tangles have been shown to correlate with dementia in Alzheim
Externí odkaz:
https://doaj.org/article/bf3ffe71579a42fe964950aaffbd2c4a
Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRDs) affect 6 million Americans and they are projected to have an estimated health care cost of $355 billion for 2021. A histopathological hallmark of AD and many ADRDs is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4e8481df43d87228e6a609b17f78ec
https://doi.org/10.1101/2021.08.06.455436
https://doi.org/10.1101/2021.08.06.455436
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Anuradha Kalani, Lewis Hutfles, Blaise W. Menta, Ian Weidling, Russell H. Swerdlow, Heather M. Wilkins, Benjamin J. Ryan, Judit Perez-Ortiz, Xiaowan Wang, T. Chris Gamblin, Scott J. Koppel
Publikováno v:
J Alzheimers Dis
Background: Mitochondrial dysfunction and tau aggregation occur in Alzheimer’s disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. Objective: To further explore how mitochondria influence tau, we measured tau oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31f313af9a48d2607c56c4d0adaf2c0
https://europepmc.org/articles/PMC7962146/
https://europepmc.org/articles/PMC7962146/
Autor:
Yamini Mutreja, Mel B. Feany, T. Chris Gamblin, Mythili Yenjerla, Liqun Wang, Farah H. Bardai
Publikováno v:
The Journal of Neuroscience. 38:108-119
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.In vitro, FTDP-17 mutant ver
Publikováno v:
Biochemistry. 58(6)
More than 50 different intronic and exonic autosomal dominant mutations in the tau gene have been linked to the neurodegenerative disorder frontotemporal dementia with Parkinsonism linked to chromosome-17 (FTDP-17). Although the pathological and clin
Autor:
Heather M. Wilkins, Ian Weidling, Xiaowan Wang, T. Chris Gamblin, Scott J. Koppel, Russell H. Swerdlow
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Qian Sun, T. Chris Gamblin
Publikováno v:
Biochemistry. 48:6002-6011
The microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer's disease (AD) and other tauopathies. In AD, there is approximately 8 mol of phosphate per mole of tau distr
Autor:
Andrew P. Riley, Smita R. Paranjape, Berl R. Oakley, Thomas E. Prisinzano, T. Chris Gamblin, C. Elizabeth Oakley, Amber D. Somoza, Clay C. C. Wang
The aggregation of the microtubule-associated protein tau is a seminal event in many neurodegenerative diseases, including Alzheimer’s disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16aa996eef2d03e3719517fb9b9739ad
https://europepmc.org/articles/PMC5112770/
https://europepmc.org/articles/PMC5112770/