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HYPEROXIA-INDUCED AIRWAY HYPERREACTIVITY IN NEONATAL GUINEA PIGS IS NOT INFLAMMATION DEPENDENT

Autor: Andrew T. Canada, Kent E. Pinkerton, Darrell W. Winsett, Daniel L. Costa, Scott R. Schulman

Publikováno v: Inhalation Toxicology. 10:15-25

A high percentage of neonatal human infants exposed to prolonged assisted ventilation with supplemental oxygen develop airway hyperreactivity. In order to demonstrate that this effect could be replicated in guinea pigs, 4-day-old pups were exposed ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13d8bcb40438155ccdce385730d122af
https://doi.org/10.1080/089583798197844

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epsilon-Aminocaproic Acid Plasma Levels During Cardiopulmonary Bypass

Autor: Elliott Bennett-Guerrero, L Ayuso, Joseph G. Reves, Mark F. Newman, Michael G. Mythen, Jonathan G. Sorohan, Andrew T. Canada

Publikováno v: Anesthesia & Analgesia. 85:248-251

epsilon-Aminocaproic acid (EACA) concentrations achieved during cardiopulmonary bypass (CPB) have not been previously reported. It is unknown whether plasma concentrations reported to inhibit fibrinolysis in vitro (130 microg/mL) are achieved or whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e290f18554da9e4f4c669dacd31463
https://doi.org/10.1213/00000539-199708000-00002

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Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs

Autor: Andrew T. Canada, Darrell W. Winsett, Scott R. Schulman, Daniel L. Costa, Allison D. Fryer

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L1211-L1216

Airway hyperreactivity is recognized as one of the long-term sequelae of bronchopulmonary dysplasia (BPD). Due to the improved care and prognosis of very low-birth weight infants, the incidence of BPD is increasing. There are data that suggest the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fbcb05796e836ddc527e851e230d9b
https://doi.org/10.1152/ajplung.1997.272.6.l1211

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Inflammation fails to explain young—Old difference in hyperoxia lethality

Autor: Andrew T. Canada

Publikováno v: Inhalation Toxicology. 7:1247-1256

The inflammation that accompanies oxygen toxicity to the lung is believed to magnify the damage and to be a significant factor in determining the ultimate extent of lung injury. The mechanism proposed for the increased lung damage associated with inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2bc626fb864daf78ddb5153bd1f09cc
https://doi.org/10.3109/08958379509029715

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The Interaction of Fentanyl on the Cp50 of Propofol for Loss of Consciousness and Skin Incision

Autor: Chris Smith, Angus I. McEwan, Rajiv Jhaveri, Michael Wilkinson, David Goodman, L. Richard Smith, Andrew T. Canada, Peter S. A. Glass

Publikováno v: Anesthesiology. 81:820-828

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c030215da3686b8fd82c3be5837f4e8
https://doi.org/10.1097/00000542-199410000-00008

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Modulation of human colonic T84 cell secretion by hydrogen peroxide

Autor: Toan D. Nguyen, Andrew T. Canada

Publikováno v: Biochemical Pharmacology. 47:403-410

Hydrogen peroxide (H2O2) is a reactive oxygen species that can be produced in the digestive tract by inflammatory cells or during reperfusion following ischemia. To evaluate a possible direct effect of H2O2 on epithelial secretory cells, well-differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e72756e488bc84543c04a340fac4654
https://doi.org/10.1016/0006-2952(94)90032-9

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Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line

Autor: Andrew T. Canada, Donald L. Trump, Cary N. Robertson, Katherine Kidd, Linda A. Herman

Publikováno v: Cancer Chemotherapy and Pharmacology. 32:73-77

Prostate cancer that is androgen-insensitive is unresponsive to a wide spectrum of cytotoxic agents, including all of the alkylating agents. Since a major pathway for the detoxification of the alkylating agents is conjugation with glutathione (GSH),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2fff2e1ef5acfe00551b383547e572
https://doi.org/10.1007/bf00685880

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