Zobrazeno 1 - 10
of 19
pro vyhledávání: '"T. C. Chiles"'
Publikováno v:
The Journal of Immunology. 159:4676-4685
We have examined herein whether membrane Ig (mIg) stimulates junB transcription through a protein kinase A (PKA)-dependent or PKA-independent pathway. PKA phosphotransferase activity was not increased following mIg cross-linking of Bal17 B cells. How
Publikováno v:
The Journal of Immunology. 157:146-155
The experiments presented herein were designed to understand the molecular mechanism(s) by which membrane Ig (mIg)-dependent signals are integrated at the level of the junB promoter to induce gene transcription. Functional studies using chloramphenic
Autor:
D A Tanguay, T C Chiles
Publikováno v:
The Journal of Immunology. 156:539-548
We examined the expression of the cyclin-dependent kinase 4, p34PSK-J3/cdk4 protein, in small dense, activated, and proliferating primary B lymphocytes. A small steady state level of cdk4 synthesis was detected in resting B cells. Stimulation of rest
Publikováno v:
The Journal of Immunology. 151:880-889
The regulation and function of CREB was examined in B cells to begin to elucidate the role of cAMP-derived signals in B cell activation. CRE-binding activity detected by the electrophoretic mobility shift assay was found to be constitutively expresse
Publikováno v:
Journal of Applied Phycology. 5:213-218
Protein extracts from 22 species of marine macroalgae from Florida and North Carolina were compared for their abilities to agglutinate sheep and rabbit erythrocytes. Protein extracts from 21 algal species agglutinated rabbit erythrocytes compared to
Autor:
T C Chiles, T L Rothstein
Publikováno v:
The Journal of Immunology. 149:825-831
The relationship between signals generated via the sIgR complex of B lymphocytes and subsequent changes in gene expression is poorly understood at the molecular level. To illuminate mechanisms that may couple these events, we examined the expression
Publikováno v:
The Journal of Immunology. 146:1730-1735
Cross-linking of sIg on primary B lymphocytes leads to increased nuclear DNA-binding activity specific for the tetradecanoyl phorbol acetate-response element (TRE), as judged by gel mobility shift assays. Stimulation of B cells to enter S phase of th
Publikováno v:
The Journal of Immunology. 146:1685-1691
Constitutive expression of NF-kappa B has been associated with developmental maturity in B cells on the basis of studies using continuously growing cell lines and plasmacytomas; however, little is known about the behavior of NF-kappa B in primary, ma
Autor:
T L, Rothstein, G M, Fischer, D A, Tanguay, S, Pavlovic, T P, Colarusso, R M, Gerstein, S H, Clarke, T C, Chiles
Publikováno v:
Current topics in microbiology and immunology. 252
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(6)
Cross-linking the B cell Ag receptor (BCR) to surface Fc receptors for IgG (Fc gamma R) inhibits G1-to-S progression; the mechanism by which this occurs is not completely known. We investigated the regulation of three key cell cycle regulatory compon