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High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer

Autor: M.L. Couvreur, B Genicot, Geert H. Blijham, J. De Greve, Harry Bleiberg, Benoit Baron, Jaques Wils, Johan W.R. Nortier, T. C. Kok, Th. Wagener, R.L.H Jansen

Publikováno v: European Journal of Cancer. 39:346-352

The aim of this study was to investigate whether N-(phosphonacetyl)-L-aspartic acid (PALA) can enhance the activity of low-dose methotrexate (LD-MTX) modulated infusional 5-fluorouracil (5-FU) in patients with advanced colorectal cancer. 198 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27d4630f28690d3fbe2e58b85e0e816e
https://doi.org/10.1016/s0959-8049(02)00662-7

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Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

Autor: Wim C. J. Hop, Peter D. Siersema, M. B. Polee, Gerrit Stoter, T. C. Kok, H. W. Tilanus, Ferry A.L.M. Eskens, M.E.L. van der Burg, A. van der Gaast, Ted A.W. Splinter

Publikováno v: British Journal of Cancer
British Journal of Cancer, 89, 2045-2050. Nature Publishing Group

The objective of this study was to identify prognostic factors for survival in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy. We analysed the baseline characteristics of 350 patients who were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1448ef8c7d7a8344d22d1f20e919ba7b
https://doi.org/10.1038/sj.bjc.6601364

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Cure of Barrett's carcinoma by ifosfamide chemotherapy

Autor: Peter D. Siersema, Herman van Dekken, Hugo W. Tilanus, T. C. Kok, Ate van der Gaast, Mariska Hage, Ernst J. Kuipers

Publikováno v: European Journal of Gastroenterology & Hepatology, 14, 1261-1264. Lippincott Williams & Wilkins

The prognosis of patients with oesophageal cancer is poor, with an overall 5-year survival rate below 15%. The best chance for cure of patients with oesophageal cancer is surgical resection. However, more than 50% of patients have inoperable disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cf1d83ee3708354e0080de412beceb
https://doi.org/10.1097/00042737-200211000-00016

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Phase II study of the combination Cisplatin, Etoposide, 5-Fluorouracil and folinic acid in patients with advanced squamous cell carcinoma of the esophagus

Autor: G. Stoter, A. van der Gaast, Peter D. Siersema, Ted A.W. Splinter, M. B. Polee, H. W. Tilanus, T. C. Kok

Publikováno v: Anti-Cancer Drugs, 12(6), 513-517. Lippincott Williams & Wilkins

The objective of this study was to determine the toxicity and the efficacy of the combination of cisplatin, etoposide, 5-fluorouracil (5-FU) and folinic acid in the treatment of patients with advanced squamous cell carcinoma of the esophagus. Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93853743895d4c06cec291b228a4e350
https://pure.eur.nl/en/publications/69eda64a-f3c8-4f67-8d04-27acc6b0eda4

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No evidence of known types of human papillomavirus in squamous cell cancer of the oesophagus in a low-risk area

Autor: H. L. Smits, J. Ter Schegget, S. P. Tjong-A-Hung, T. C. Kok, Kees Nooter

Publikováno v: European Journal of Cancer, 33(11), 1865-1868. Elsevier Ltd.
European Journal of Cancer, 33, 1865-1868. Elsevier

Controversial results regarding the presence and role of human papillomavirus in the development of oesophageal squamous cell carcinoma have been published. We used multiple broad-spectrum polymerase chain reactions to identify HPV DNA in oesophageal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1413c9c6866aa333d5617ea4cdb83d92
https://hdl.handle.net/11245/1.134688

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Cisplatin and etoposide in oesophageal cancer: a phase II study

Autor: H. W. Tilanus, H. Van Overhagen, T. C. Kok, G. Stoter, A. van der Gaast, Jan Dees, W. M. H. Eykenboom, Ted A.W. Splinter

Publikováno v: British Journal of Cancer. 74:980-984

In the search for effective chemotherapy regimens which can be used in multimodality treatment programmes for patients with cancer of the oesophagus, we conducted a phase II trial to determine the activity and toxicity of the combination of cisplatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b56e2cb37729a01fcd5f85b5007fc703
https://doi.org/10.1038/bjc.1996.469

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Evaluation of a new tumour marker in patients with non-small-cell lung cancer: Cyfra 21.1

Autor: T. C. Kok, Ted A.W. Splinter, B. G. Blijenberg, C. H. H. Schoenmakers, A. van der Gaast, F. Cornillie

Publikováno v: British Journal of Cancer

The Cyfra 21.1 assay is a newly developed test which measures in serum a fragment of cytokeratin 19. We evaluated this marker in 212 patients with non-small-cell lung cancer (NSCLC), predominantly stage 3a-b and 4, and compared it with three other ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584df35d8ef8d344887c02ba952bab1f
https://doi.org/10.1038/bjc.1994.95

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Chemotherapy Followed by Surgery versus Surgery Alone in Patients with Resectable Oesophageal Squamous Cell Carcinoma: Long-term Results of a Randomized Controlled Trial

Autor: Bas P. L. Wijnhoven, J. Jan B. van Lanschot, Ate van der Gaast, Jurjen J. Boonstra, T. C. Kok, Peter D. Siersema, Hugo W. Tilanus, Fiebo J.W. ten Kate, Winand N.M. Dinjens, Mark van Heijl, Mark I. van Berge Henegouwen

Publikováno v: BMC Cancer, 11. BioMed Central Ltd.
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 181 (2011)
BMC Cancer, 11(1). BioMed Central
BMC cancer, 11(1). BioMed Central

Background This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting of 2-4 cycles of cisplatin and etoposide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c343dd900a7a1a08082a272399096087
https://doi.org/10.1186/1471-2407-11-181

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Assessment of Response of Esophageal Carcinoma to Induction Chemotherapy

Autor: J. H. P. Wilson, A. H. Mulder, M. L. Hordijk, T. C. Kok

Publikováno v: Endoscopy. 25:592-596

Endoscopic ultrasonography (EUS) is currently considered the best available technique for the local staging of esophageal cancer. In a prospective study 11 patients with esophageal squamous cell carcinoma were investigated to evaluate the usefulness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5343f4c1895f0912f0c3d3a83316854
https://doi.org/10.1055/s-2007-1010411

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