Zobrazeno 1 - 10
of 10
pro vyhledávání: '"T. Bruce Brown"'
Autor:
James E. Taylor, Andrew D. Smith, David C. Pryde, Alexandra M. Z. Slawin, Stuart M. Leckie, T. Bruce Brown, Tomas Lebl, Charlene Fallan
Publikováno v:
Synlett. 24:1243-1249
NHC-mediated enantioselective formal [4+2] cycloadditions of alkylarylketenes with γ-substituted-β,γ-unsaturated α-ketophosphonates is described. A substrate-dependent switch in diastereoselectivity was observed, with γ-aryl α-ketophosphonates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b54d6cecdff98f6312e3065e5a0d099
https://doi.org/10.1055/s-0033-1338851
https://doi.org/10.1055/s-0033-1338851
Autor:
Christopher Ronald Smith, Nicholas Puhalo, Andrew A. Calabrese, Lindsay Brown, Olga Wallace, Dave Ellis, T. Bruce Brown, Alan Daniel Brown, Lesa Watson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5242-5244
Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7473c8b1c8a93b6fb8cb54a202a15
https://doi.org/10.1016/j.bmcl.2008.08.066
https://doi.org/10.1016/j.bmcl.2008.08.066
Autor:
Alexandra M. Z. Slawin, James E. Taylor, Charlene Fallan, T. Bruce Brown, Tomas Lebl, Stuart M. Leckie, David Pryde, Andrew D. Smith
Publikováno v:
ChemInform. 44
A substrate-depending diastereoselectivity is observed which provides predominantly the syn products from γ-aryl α-ketophosphonates of type (II) and (VII).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee16d5a910261904beeb40df8c5e069
https://doi.org/10.1002/chin.201340140
https://doi.org/10.1002/chin.201340140
Autor:
T. Bruce Brown, Tomas Lebl, David Pryde, Andrew D. Smith, Stuart M. Leckie, Alexandra M. Z. Slawin
Publikováno v:
ChemInform. 44
Chiral N-heterocyclic carbenes promote the asymmetric formal [4 + 2] cycloaddition of alkylarylketenes with β,γ-unsaturated α-ketocarboxylic esters and amides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f59130ed65ff833d3d595a3ac04cda
https://doi.org/10.1002/chin.201336135
https://doi.org/10.1002/chin.201336135
Autor:
Stuart M. Leckie, David Pryde, Alexandra M. Z. Slawin, Andrew D. Smith, Tomas Lebl, T. Bruce Brown
Publikováno v:
Organicbiomolecular chemistry. 11(19)
Chiral N-heterocyclic carbenes (NHCs) promote the asymmetric formal [4 + 2] cycloaddition of alkylarylketenes with β,γ-unsaturated α-ketocarboxylic esters and amides. Divergent diastereoselectivity is observed in this process, with γ-aryl-β,γ-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31ff88b6f5d32f3931cfbcb579467b
https://pubmed.ncbi.nlm.nih.gov/23584232
https://pubmed.ncbi.nlm.nih.gov/23584232
Autor:
Mark L. Lewis, Nick Edmunds, Stefan Sultana, Natalie M. Mount, Mark Ian Lansdell, Peter Wilson, Anne C. Heatherington, T. Bruce Brown, Alan Daniel Brown, Sarah Tweedy, David Hepworth, Julian Blagg, Cathryn Adams, Samantha Gaboardi, Kim Tang, Stevie Neal-Morgan, Andrew A. Calabrese, Neela Mistry, Maria Sudworth, David Sebastien Fradet, Neil Feeder, Val Gillon, Susan Cole, Steven W. Martin, Faye J. Quinton, Joanne Phipps, Scott Haughie, Denise J. Burring, Peter Stacey, Hugh Verrier, Chris Wayman
Publikováno v:
Journal of medicinal chemistry. 53(8)
The relevance of the melanocortin system to sexual activity is well established, and nonselective peptide agonists of the melanocortin receptors have shown evidence of efficacy in human sexual dysfunction. The role of the MC4 receptor subtype has rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05a704b9e20c9d6ce95d234dd7627d0
https://pubmed.ncbi.nlm.nih.gov/20329799
https://pubmed.ncbi.nlm.nih.gov/20329799
Autor:
Andrew A. Calabrese, Dave Ellis, Michael J. Ralph, Alan Daniel Brown, Lesa Watson, Nicholas Puhalo, T. Bruce Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
A series of aryloxyazetidines, aryloxypyrrolidines and aryloxypiperidines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in these new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea95352ec099a4104bd9b85a1567819
https://pubmed.ncbi.nlm.nih.gov/19963374
https://pubmed.ncbi.nlm.nih.gov/19963374
Autor:
Andrew A. Calabrese, Lindsay Brown, T. Bruce Brown, Nicholas Puhalo, Lesa Watson, Christopher Ronald Smith, Olga Wallace, Alan Daniel Brown, Dave Ellis
Publikováno v:
ChemInform. 40
Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a089ca2bad22e3a5494d691a2567c726
https://doi.org/10.1002/chin.200908163
https://doi.org/10.1002/chin.200908163
ChemInform Abstract: A Convenient Synthesis of Highly Substituted 3-N,N-Dialkylamino-1,2,4-triazoles
Autor:
T. Bruce Brown, Michael J. Ralph, David M. Beal, David W. Gordon, David V. Batchelor, Patrick S. Johnson, Toby J. Underwood, Simon Wheeler, Helen J. Mason, David Ellis
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd6e595668b29637a50290aff245b5e
https://doi.org/10.1002/chin.200905133
https://doi.org/10.1002/chin.200905133
Autor:
David A. Smith, Tamba A. Dauda, David Cardamone, A. G. Youtsos, Hieronymus Hein, Didier Lawrjaniec, Christian Boucher, P. John Bouchard, Michael Smith, T. Bruce Brown, Christopher E Truman, D. Carsten Ohms
Publikováno v:
Volume 6: Materials and Fabrication.
ENPOWER is a EURATOM collaborative research project sponsored by the European Union. The aim is to produce advanced weld repair techniques and residual stress mitigation procedures for nuclear components in order to eliminate the need for expensive g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da67a4f9512634173f129a34e6cedff
https://doi.org/10.1115/pvp2005-71771
https://doi.org/10.1115/pvp2005-71771